DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and nsd1b

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_005173940.1	Gene:	nsd1b / 564592	ZFINID:	ZDB-GENE-080519-2	Length:	1873	Species:	Danio rerio

Alignment Length:	1791	Identity:	331/1791 - (18%)
Similarity:	544/1791 - (30%)	Gaps:	623/1791 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LANNQFAS--KEKKHKDKEEEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHT 107
            :.||...|  ..:|.|:|::......|..||:...|.::.|.:|:                 |::
Zfish   290 IQNNHLNSLPHNRKSKNKKKPTISHCRISEELNCEKGMIMDALDS-----------------PYS 337

  Fly   108 KCEIEEEGRKEMEYDQDVAKQDSEMEKKQNGKATSITVKMESNERAEKH---------ATEIATT 163
                          |.|...|.....|              |||:...|         ||.....
Zfish   338 --------------DIDSVPQIRRFPK--------------SNEQISNHYVINYKQSSATPTVLP 374

  Fly   164 STERWENESFKTEQQNKKAAEKEEEPILAATQKLEAN--------AEPLTTTRIEVAVASPLVVS 220
            ||         .::..||..|.:.....:.|.|.:.|        :...:..::...:..|   .
Zfish   375 ST---------NDKDVKKNVENQGGLWFSKTGKGQVNGISRAGIKSVNCSFGKVSCKIKMP---D 427

  Fly   221 SASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENKKF 285
            |||:| ..|..|......|..|....|:.|:..|..:|...|..:.::......:....:|.|
Zfish   428 SASMK-PKDNHNTGLEHLSTEAKKALDRRVKCLPASSRLMTRALKAMEDAEWTKESSSDLETK-- 489

  Fly   286 GKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTALSPEENSAPAPKRGRGRARKIRPDA 350
                   :|.|..                    |.|||.. |...||....|........::.|:
Zfish   490 -------NCVSSF--------------------DSPSLET-SDVHNSILLQKMPTAAIHDLKEDS 526

  Fly   351 EVET----SEVILPCED-----------SLGEKKP------GRKRK-----LPDEPI-------- 381
            ::.|    |..:|.|:|           ||..:.|      .||:.     |...|.
Zfish   527 KISTHAKLSSELLCCKDDEHSVKSEDESSLVSQAPCAFHSSTRKQNSHVNDLSSSPTPSLHLNLK 591

  Fly   382 DQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADG----------------SPWEEV 430
            |...::::.......|..|. ||.              .|.|.                |..::.
Zfish   592 DMDNMNEISFKSLANEHSGQ-PLS--------------FHPDSNYKFSTFLMMLKDMHDSREKDG 641

  Fly   431 KTEALHPQPSAELSFAEVTSEILPLA-VLDEKTPPKKRGRKAKTPCVKLESETSCGLPFANGNKK 494
            ....:.|.|:.||    :..|.|.:: |.|||...|::..|.||   .:.||..    .|:...|
Zfish   642 NVLVVEPLPTTEL----INEEPLLISDVKDEKATSKQKKVKPKT---NVMSENH----LASTISK 695

  Fly   495 TNSSGGCELQLPKRS---KRRI--KPTPKILENDELRC-EFETKHIERM--TQWE--------SA 543
            |......::.|.|::   |..|  |...|::....|.. |.||.....:  .:|:        :.
Zfish   696 TAQRSSKKISLKKKTTDIKANIDYKSFDKLISAHRLTSKEAETNFSANVPKKRWQKFDQVSEKTV 760

  Fly   544 AAVDGDFETPTTGGNGSNSSTSRQKSDKS-------DGSNFEGGPGHPAGTSAIK--KRLFSKSQ 599
            ..|:|:....|...:..|...|...::||       ..:..|...|:...|.|..  ||:...|:
Zfish   761 HIVEGNCIHKTERVSSENCDVSMDGTNKSCFFGPETTSNALECNQGNCQNTEAPTECKRIRKPSK 825

  Fly   600 RDI---ENYGAAMLAKSKLPPCPD-------------VEQFLNDIK----ASRINANR------- 637
            |.|   |.|.....||.|....||             |.:..:::|    .:..:.:|
Zfish   826 RLIEWTEEYDQLFSAKKKAKKKPDSVTKIENQKCSEPVAKTYDEVKQKPQVTEQDVSRRLPELQT 890

  Fly   638 -SPEERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLR 701
             .||::..:......|..|:.:.|....|.......||..|:.:..::......|.|| .||.|
Zfish   891 PPPEDQSQSTPLINTLPCQESQVLSAETLTPPPEIIPSPCDNISNRDQLQRQNPVAVG-DSVCL- 953

  Fly   702 VRNSVTKELPTTATLKS--RRNPVVQAAKLTRRIGARAAGEVTEAA----------RASVPISTP 754
              ||..:..||...|:|  ...|::...:..:.:...::|..|.:.          :.|:..|.|
Zfish   954 --NSKRQRKPTKKILESSIEAEPILIPKRKMKSMKICSSGHSTNSGVEQQSSKSKNKLSIESSDP 1016

  Fly   755 DAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQK 819
            .::.:.. .|.::.||:|                 .:.|..:...|.:..|:..|......:..:
Zfish  1017 PSDPMLK-STEMEIDVSP-----------------AVLQTINTESADDGSDTLRCSGSQMTESSE 1063

  Fly   820 IGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQS--HNCCAGCGIFCTQGKFVLCKQQ--HFF 880
            .....|.:|:...:|..|:|:|      |.|....|  .|.|..|.   .||..:||:.|  ..|
Zfish  1064 FYSEREENSQSDKVLLDSRRLS------EEKGGSTSVKENVCPMCE---KQGDLLLCEGQCCGAF 1119

  Fly   881 HPDC-------AQRFILSTSYE--------KELGDEEDQGVKFSSPVLVLKC--PHCG------- 921
            ||.|       ..:|:......        |.||::            |.:|  |.||
Zfish  1120 HPQCTGLNEPPTGKFLCQECTSGVHSCFACKRLGED------------VRRCMVPGCGKFYHGEC 1172

  Fly   922 --LDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLST 984
              ...|........:|   |:......:.:.||..:.:                     ||.|:.
Zfish  1173 AASHAPTVPLNRAFRC---PLHACLSCFILNPANPSVA---------------------KGQLTR 1213

  Fly   985 AVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVM-----NVVLRGHVVSASG 1044
            .:....                         |.:|.:|.  ||...:     |:|...|
Zfish  1214 CIRCPV-------------------------AYHSSDFC--IPAGSVTLTDSNIVCPNH------ 1245

  Fly  1045 RVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKG 1109
                 ||||.   ..:|                    .|::|.:...:.:..|:     ||.|:
Zfish  1246 -----FTPRK---GCRN--------------------HEHVNVSWCFVCSEGGS-----LLCCE- 1276

  Fly  1110 ASSPDFVNIVDYELRTALMCAVMNEKC---DMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEA 1171
             |.|                |..:.:|   ||......|....|.|.|..|            |.
Zfish  1277 -SCP----------------AAFHRECLNIDMPEGSWYCNDCRAGKKPHYK------------EV 1312

  Fly  1172 TQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFIS 1236
            ..:.|..||                   |    |.||:.:.
Zfish  1313 VWVKVGRYR-------------------W----WPAEVSNP------------------------ 1330

  Fly  1237 FLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRM 1301
                :|...||                                            :..:|.|...
Zfish  1331 ----KDIPENI--------------------------------------------LRMKHDVGEF 1347

  Fly  1302 CIALIANGADLMIKNKAEQLPF-DCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASNGRE 1365
            .: |.....|.:...:|...|: :...|.:.:.|:.|. :...::.....||...:.|:    :|
Zfish  1348 PV-LFFGSNDYLWTYQARVFPYMEGDANSKEKMGKGVD-STYKKALDEAALRFKELQAE----KE 1406

  Fly  1366 ARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQ 1430
            .|.:|           ||..:....|.::          .:::::...::.|.|. |.....||.
Zfish  1407 LRQLQ-----------EDRRNDKKPPPYK----------QIKVNKPFGKVLIISA-DLSEIPRCN 1449

  Fly  1431 CNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPLQIVECEDQA 1494
            |..       |.|:....|....:..:::||: .||...: .|:|:....  |...|:......:
Zfish  1450 CKA-------TDENPCGMDSECINRMLLYECHPQVCPAGE-RCQNQCFIK--RQYCQVETFRTLS 1504

  Fly  1495 KGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDS--------YYFDLDNGHCIDANYYGNVT 1551
            :|||:|.:.::.||.|:..|.||::...|...|...:        |...||....|||...||..
Zfish  1505 RGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEA 1569

  Fly  1552 RFFNHSCEPNVLPVRVFYEHQDYRF---PKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVG-- 1611
            ||.||.|:||.       |.|.:..   .::..||..||.||.|:.|:|        :..|:|
Zfish  1570 RFMNHCCQPNC-------ETQKWTVNGDTRVGLFSLTDIPAGTELTFNY--------NLECLGNG 1619

  Fly  1612 ---CRCLTTTCKYASQSSSTNASPTNATTAPENETG 1644
               |:|..:.|     |......|.|  ..|.::.|
Zfish  1620 KTVCKCGASNC-----SGFLGVRPKN--NPPSDDKG 1648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	22/114 (19%)
		Ank_2	1056..1152	CDD:289560	15/98 (15%)
		ANK	1088..1217	CDD:238125	23/131 (18%)
		ANK repeat	1088..1120	CDD:293786	6/31 (19%)
		ANK repeat	1124..1153	CDD:293786	6/31 (19%)
		Ank_2	1127..1249	CDD:289560	20/124 (16%)
		ANK	1155..1306	CDD:238125	14/150 (9%)
		ANK repeat	1155..1196	CDD:293786	5/40 (13%)
		ANK repeat	1199..1249	CDD:293786	7/49 (14%)
		Ank_2	1205..1316	CDD:289560	10/110 (9%)
		ANK repeat	1251..1283	CDD:293786	0/31 (0%)
		ANK repeat	1285..1316	CDD:293786	4/30 (13%)
		PreSET	1357..1466	CDD:128744	19/109 (17%)
		SET	1495..1602	CDD:214614	38/117 (32%)
nsd1b	XP_005173940.1	PWWP	132..>204	CDD:321985
		TOP2c	<652..1020	CDD:330395	81/382 (21%)
		PHD_SF	1098..1140	CDD:328929	12/44 (27%)
		PHD_SF	1145..1191	CDD:328929	11/60 (18%)
		PHD_SF	1193..1245	CDD:328929	12/99 (12%)
		PHD4_NSD1	1262..1301	CDD:277126	11/61 (18%)
		WHSC1_related	1307..1401	CDD:99899	24/202 (12%)
		AWS	1444..1494	CDD:197795	13/59 (22%)
		SET	1497..1618	CDD:214614	39/135 (29%)
		PHD5_NSD1	1668..1710	CDD:277129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840