Protein Alignment G9a and nsd1a

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_683890.5
• Gene: nsd1a / 556086
• ZFINID: ZDB-GENE-080519-3
• Length: 2053
• Species: Danio rerio
• Alignment Length: 1962
• Identity: 349/1962 - (17%)
• Similarity: 594/1962 - (30%)
• Gaps: 738/1962 - (37%)

  Fly     1 MTDFVELMNSMSSTFNSDC-ATSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEE 64
            |.||    :||....:||| ..||....::.||              :.:..|....|.:.....
Zfish   230 MEDF----DSMDDYSDSDCDLPSTENCASIFNL--------------SKRAHSPSDSHSNPSSSP 276

  Fly    65 RKEARNQEEIEDIKALLADVVDAAAVKLEEE-----EAQNAEKVEPHTKCE-------------- 110
            :|     :::..:|..:.|||.|   |....     ......:::.|||.:
Zfish   277 KK-----KQLLSVKYSIGDVVWA---KFNRRPWWPCHVTTDPQIDVHTKMKDPSRRPCRLYFVRM 333

  Fly   111 -----------------------------IEEEGR-KEMEYDQDVAKQDSEMEKKQNGKATSITV 145
                                         :...|| ||.:|...|.|:.....|....:|.:...
Zfish   334 FGEIVDQAWVPAKATFPFEGGDQFEKLPVLRRRGRQKEKDYKYTVPKRLIPSWKASVLEAEASLT 398

  Fly   146 KMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIE 210
            |..::|.......::....||         ::.:||      .|....:..|...:..|.:..:.
Zfish   399 KQLNSEPPLTLIQDVCVPITE---------DKAHKK------NPACPKSTTLSTPSSSLLSNGLN 448

  Fly   211 VAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTS--- 272
            .:|.:.|...:||.|.|.....|.::...:...:|...  :.:|...:.|..|. |:|:|.|
Zfish   449 ASVKNRLKPGTASKKKATKKMIQSQSIKLSETPSLFKS--KSNPSSDKPSIATD-PLDSPYSDID 510

  Fly   273 ---------VTDEHVQVENKK--FGKSEQYTDCSSHLERFTLD------DNTAIVRLQL-KSEPD 319
                     ..||.:|||.:|  ..|:.:...|.. ..:.::|      |...:...:| ||.|.
Zfish   511 SVPRILCSKRIDESLQVELEKELSTKTTKVQACKK-TSKNSVDKPGKKTDVKCLKNSKLKKSTPK 574

  Fly   320 KPSLTALSP--EENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSL-------GEKKPGRKRK 375
            ..:|.|.|.  :|:|:|...           |.........||....|       ||:.  :::.
Zfish   575 DKTLKATSSRLKESSSPGSS-----------DGSFAMHSHYLPASSGLIVRALAAGEET--KEKD 626

  Fly   376 LPDEPIDQQQLSD--------------LVVVKTEQEE----LGDAPLG--DVKRMRRSVRLGNRL 420
            |..||......|:              .|..|:|..|    ..|:|..  .:||:::..: .|.:
Zfish   627 LSHEPNSHSPSSEHSSPTNHELSKQNWEVKNKSESSEESADASDSPPNPTSIKRIKKRPQ-KNGI 690

  Fly   421 HADGSPWEEVKTEALHPQPSAELSFAEVTSEILP---LAVLDEKTPPKKRGRKA--KTPCVKLES 480
            |.|..|....::|:   :.:.|..|::.:|..:|   ::.:|.....|:...::  |..|...||
Zfish   691 HKDPPPKSHEESES---KVNNESMFSDTSSSSIPSPSISPMDAFQDIKELSFRSLVKEECSSGES 752

  Fly   481 ETSCGLPFANGNKK-------------TNSSGGCELQLPKRS-KRRIKPTPKIL-----ENDELR 526
            ...     |:.|.|             :....|..|.||..| ...||..|.::     ..:|:.
Zfish   753 PLR-----ADSNYKFSTFLMLLKDLHDSREKEGKPLTLPPTSPSSLIKEEPSLIPVGEEPPNEVL 812

  Fly   527 CEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNS-----STSRQKSDKSDGSNFEGGPGHPAG 586
            ||.|         :...:::.|...||   .|...|     ||.:::|.|.|
Zfish   813 CEKE---------FAEQSSLPGKTSTP---NNSKQSKAKLKSTVKKESQKPD------------- 852

  Fly   587 TSAIKKRLFSKSQRDIENYGAAMLAKS-----KLPPCPDVEQFLNDIKASRINANRSPEER-KLN 645
               |.....|..::.|...|..:|.||     .||...||...:.|:.|....:..:|::| |..
Zfish   853 ---IVIDSVSPLKKPISPVGLDVLDKSLPLLGDLPKSSDVSAAVTDVCAKGTISKVAPKKRWKTF 914

  Fly   646 KKQQRKLAKQKEKHLKHL-----------------GLQKN-HRDEPSDNDSSNTD---------- 682
            :.:..|..|.|...:...                 |||:: |.|.|:..|:|...
Zfish   915 ESELGKSIKPKSDQVDSTLDEVKSVSTEPNGVFKDGLQESAHSDVPNKKDASENKRLRKPSKRLI 979

  Fly   683 ------NEFFP--------------------TTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRN 721
                  .:.||                    ||..|.....:|....:|.:.|.|....:...:.
Zfish   980 ECGEEYEQIFPSKKKTKKSTESCKTGSCISNTTPEQPASDQITPDAVSSSSAEKPLDHDVAEEQK 1044

  Fly   722 PVV-------------------------QAAKLTRRIGARAAGEVTEAA---------------- 745
            |..                         ::|.|.|:...::..:|.:.|
Zfish  1045 PPADVLVPPSAPKSPSCATSLETEPCEKKSAPLERKRPRKSVHKVLDCAIEGESVKIPKKGESRQ 1109

  Fly   746 -----------------RASVPISTPDAEQLHS---LDTS--IQADVTPIRDLDMRPSTSRVSKF 788
                             .|..|.|:|.|....|   |.||  ||.||..:..:.:....|..|
Zfish  1110 HKTNPEESGVRDLEKQEEAGPPPSSPCAVSAQSEGELRTSSPIQPDVPSVSQIPVEGEQSSPS-- 1172

  Fly   789 ICLCQKP---------SQYYARNAPDSSYCCAIDHIDDQKIG-CCNELSSE-------VHNLLRP 836
                 ||         |:.:.....||:: .:.|.:.....| ..|:.|.|       ..|:.:.
Zfish  1173 -----KPQMNNEDSLISEGFGAGLNDSAF-SSRDSLSGDLSGLSTNKRSVERGGGASLKENVCQV 1231

  Fly   837 SQRVSYMILCDEHKKRLQSHNCCAGCGIFC------TQGKFV------------LCKQQ------ 877
            .::...::||:        ..||....:.|      .:|:|:            :||:.
Zfish  1232 CEKTGELLLCE--------GQCCGAFHLQCIGLTETPKGRFICQECKMGVHTCFVCKKPDKEVRR 1288

  Fly   878 -------HFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKC 935
                   .|:|.||.                    :|:|..|...:...|.:.       |.:.|
Zfish  1289 CMIPVCGKFYHMDCI--------------------LKYSPTVAQNRGFRCSIH-------VCLSC 1326

  Fly   936 QSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNG 1000
            .                             :.|.|.||.   :||.|:..|....|
Zfish  1327 Y-----------------------------ITNPNNPGI---SKGRLTRCVRCPVA--------- 1350

  Fly  1001 AQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLE 1065
                         .||.:....|..:|.:..:.:...|           ||||.   ..:|
Zfish  1351 -------------YHANDYCMAAGSVPLANNSFLCPNH-----------FTPRK---GCKN---- 1384

  Fly  1066 RVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCA 1130
                            .|::|.:...:.:..|:     ||.|:  |.|                |
Zfish  1385 ----------------HEHINVSWCFVCSEGGS-----LLCCE--SCP----------------A 1410

  Fly  1131 VMNEKCDMLNLFLQ-----CGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLS 1190
            ..:.:|  ||:.:.     |....|.|.|..|..|.:.            |..||
Zfish  1411 AFHREC--LNIEMPQGSWFCNDCRAGKKPHYKDILWVK------------VGRYR---------- 1451

  Fly  1191 FIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTV 1255
                     |    |.||     :.:..|:|:.:
Zfish  1452 ---------W----WPAE-----VTQPKSVPENI------------------------------- 1467

  Fly  1256 LHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQ 1320
                                   ..:::..|:.|:|              .....|.:...:|.
Zfish  1468 -----------------------SRMKHEVGEFPVH--------------FFGSKDYVWTYQAR- 1494

  Fly  1321 LPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEA 1385
                |.|..|.:....          ..:|.....|...|.|....|..::::.:......||..
Zfish  1495 ----CFPYMEGDANNK----------EKMGKGADAVYKKALNEAADRFRELLKEKEMRQLQEDRK 1545

  Fly  1386 DSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADF 1450
            :....|.:::          :::::::.::.|.:. |.....||.|..       |.|:....|.
Zfish  1546 NDKKPPPYKH----------IKVNKQIGKVLIITA-DLSEIPRCNCKA-------TDENPCGIDS 1592

  Fly  1451 NYEDPAVIFEC-NDVCGCNQLSCKNRVVQNGTRTPLQIVECE---DQAKGWGVRALANVPKGTFV 1511
            ...:..:::|| :.||...: .|     ||.:.|..|..|.|   ..::|||:|:::::.||.||
Zfish  1593 ECINRMLLYECHSQVCPAGE-RC-----QNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFV 1651

  Fly  1512 GSYTGEILTAMEADRRTDDS--------YYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVF 1568
            ..|.||::...|...|..::        |...||....|||...||.:||.||||:||.
Zfish  1652 NEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNC------ 1710

  Fly  1569 YEHQDYRF---PKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVG-----CRCLTTTCKYASQS 1625
             |.|.:..   .::..|:..||..|.|:.|:|        :..|:|     |:|....|......
Zfish  1711 -ETQKWTVNGDTRVGLFALEDIPKGVELTFNY--------NLECLGNGKTVCKCGAPNCSGFLGV 1766

  Fly  1626 SSTNASPTNATT 1637
            ...|..|::..|
Zfish  1767 RPKNQPPSDDKT 1778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	24/168 (14%)
		EHMT_ZBD	786..933	CDD:411018	30/194 (15%)
		ANKYR	1063..1322	CDD:440430	32/263 (12%)
		ANK repeat	1088..1120	CDD:293786	6/31 (19%)
		ANK repeat	1124..1153	CDD:293786	6/33 (18%)
		ANK repeat	1155..1196	CDD:293786	5/40 (13%)
		ANK repeat	1199..1249	CDD:293786	6/49 (12%)
		ANK repeat	1251..1283	CDD:293786	0/31 (0%)
		ANK repeat	1285..1316	CDD:293786	4/30 (13%)
		SET_EHMT	1391..1622	CDD:380941	63/250 (25%)
nsd1a	XP_683890.5	None