DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and nsd1a

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_683890.4 Gene:nsd1a / 556086 ZFINID:ZDB-GENE-080519-3 Length:2055 Species:Danio rerio


Alignment Length:1962 Identity:349/1962 - (17%)
Similarity:595/1962 - (30%) Gaps:738/1962 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTDFVELMNSMSSTFNSDC-ATSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEE 64
            |.||    :||....:||| ..||....::.||              :.:..|....|.:.....
Zfish   230 MEDF----DSMDDYSDSDCDLPSTENCASIFNL--------------SKRAHSPSDSHSNPSSSP 276

  Fly    65 RKEARNQEEIEDIKALLADVVDAAAVKLEEE-----EAQNAEKVEPHTKCE-------------- 110
            :|     :::..:|..:.|||.|   |....     ......:::.|||.:              
Zfish   277 KK-----KQLLSVKYSIGDVVWA---KFNRRPWWPCHVTTDPQIDVHTKMKDPSRRPCRLYFVRM 333

  Fly   111 -----------------------------IEEEGR-KEMEYDQDVAKQDSEMEKKQNGKATSITV 145
                                         :...|| ||.:|...|.|:.....|....:|.:...
Zfish   334 FGEIVDQAWVPAKATFPFEGGDQFEKLPVLRRRGRQKEKDYKYTVPKRLIPSWKASVLEAEASLT 398

  Fly   146 KMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIE 210
            |..::|.......::....||         ::.:||      .|....:..|...:..|.:..:.
Zfish   399 KQLNSEPPLTLIQDVCVPITE---------DKAHKK------NPACPKSTTLSTPSSSLLSNGLN 448

  Fly   211 VAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTS--- 272
            .:|.:.|...:||.|.|.....|.::...:...:|...  :.:|...:.|..|. |:|:|.|   
Zfish   449 ASVKNRLKPGTASKKKATKKMIQSQSIKLSETPSLFKS--KSNPSSDKPSIATD-PLDSPYSDID 510

  Fly   273 ---------VTDEHVQVENKK--FGKSEQYTDCSSHLERFTLD------DNTAIVRLQL-KSEPD 319
                     ..||.:|||.:|  ..|:.:...|.. ..:.::|      |...:...:| ||.|.
Zfish   511 SVPRILCSKRIDESLQVELEKELSTKTTKVQACKK-TSKNSVDKPGKKTDVKCLKNSKLKKSTPK 574

  Fly   320 KPSLTALSP--EENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSL-------GEKKPGRKRK 375
            ..:|.|.|.  :|:|:|...           |.........||....|       ||:.  :::.
Zfish   575 DKTLKATSSRLKESSSPGSS-----------DGSFAMHSHYLPASSGLIVRALAAGEET--KEKD 626

  Fly   376 LPDEPIDQQQLSDLV------------VVKTEQE------ELGDAPLG--DVKRMRRSVRLGNRL 420
            |..||......|:..            .||...|      :..|:|..  .:||:::..: .|.:
Zfish   627 LSHEPNSHSPSSEHSSQTNHELSKQNWEVKNNSESSEESVDASDSPPNPTSIKRIKKRPQ-KNGI 690

  Fly   421 HADGSPWEEVKTEALHPQPSAELSFAEVTSEILP---LAVLDEKTPPKKRGRKA--KTPCVKLES 480
            |.|..|....::|:   :.:.|..|::.:|..:|   ::.:|.....|:...::  |..|...||
Zfish   691 HKDPPPKSHEESES---KVNNESMFSDTSSSSIPSPSISPMDAFQDIKELSFRSLVKEECSSGES 752

  Fly   481 ETSCGLPFANGNKK-------------TNSSGGCELQLPKRS-KRRIKPTPKIL-----ENDELR 526
            ...     |:.|.|             :....|..|.||..| ...||..|.::     ..:|:.
Zfish   753 PLR-----ADSNYKFSTFLMLLKDLHDSREKEGKPLTLPPTSPSSLIKEEPSLIPVGEEPPNEVL 812

  Fly   527 CEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIK 591
            ||.|         :...:::.|...||    |.|..|.::.|                   |.:|
Zfish   813 CEKE---------FAEQSSLPGKTSTP----NNSKQSKAKLK-------------------STVK 845

  Fly   592 KR---------LFSKSQRDIENYGAAMLAKS-----KLPPCPDVEQFLNDIKASRINANRSPEER 642
            |.         ..|..::.|...|..:|.||     .||...||...:.|:.|....:..:|::|
Zfish   846 KESQKPDVVIDSVSPLKKPISPVGLDVLDKSLPLLGDLPKSSDVSAAVTDVCAKGTISKVAPKKR 910

  Fly   643 -KLNKKQQRKLAKQKEKHLKHL-----------------GLQKN-HRDEPSDNDSSNTD------ 682
             |..:.:..|..|.|...:...                 |||:: |.|.|:..|:|...      
Zfish   911 WKTFESELGKSIKPKSDQVDSTLDEVKSVSTEPNGVFKDGLQESAHSDVPNKKDASENKRLRKPS 975

  Fly   683 ----------NEFFP--------------------TTRVQVGKPSVTLRVRNSVTKELPTTATLK 717
                      .:.||                    ||..|.....:||...:|.:.|.|....:.
Zfish   976 KRLIECGEEYEQIFPSKKKTKKSTESCKTGSCISNTTPEQPASDQITLDAVSSSSAEKPLDHVVA 1040

  Fly   718 SRRNPVV-------------------------QAAKLTRRIGARAAGEVTEAA------------ 745
            ..:.|..                         ::|.|.|:...::..:|.:.|            
Zfish  1041 EEQKPPADVLVPPSAPKSPSCATSLETEPCEKKSAPLERKRPRKSVHKVLDCAIEGESVKIPKKG 1105

  Fly   746 ---------------------RASVPISTPDAEQLHS---LDTS--IQADV-----TPIRDLDMR 779
                                 .|..|.|:|.|....|   |.||  ||.||     .|:......
Zfish  1106 ESRQHKTNPEESGVRDLEKQEEAGPPPSSPCAVSAQSEGELRTSSPIQPDVPSVSQIPVEGEQSS 1170

  Fly   780 PSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIG-CCNELSSE-------VHNLLRP 836
            ||..:::....|.   |:.:|....||:: .:.|.:.....| ..|:.|.|       ..|:.:.
Zfish  1171 PSKPQINNEDSLI---SEGFAAGLNDSAF-SSRDSLSGDLSGLSTNKRSVERGGGASLKENVCQV 1231

  Fly   837 SQRVSYMILCDEHKKRLQSHNCCAGCGIFC------TQGKFV------------LCKQQ------ 877
            .::...::||:        ..||....:.|      .:|:|:            :||:.      
Zfish  1232 CEKTGELLLCE--------GQCCGAFHLQCIGLTETPKGRFICQECKMGVHTCFVCKKPDKEVRR 1288

  Fly   878 -------HFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKC 935
                   .|:|.||.                    :|:|..|...:...|.:.       |.:.|
Zfish  1289 CMIPVCGKFYHMDCI--------------------LKYSPTVAQNRGFRCSIH-------VCLSC 1326

  Fly   936 QSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNG 1000
            .                             :.|.|.||.   :||.|:..|....|         
Zfish  1327 Y-----------------------------ITNPNNPGI---SKGRLTRCVRCPVA--------- 1350

  Fly  1001 AQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLE 1065
                         .||.:....|..:|.:..:.:...|           ||||.   ..:|    
Zfish  1351 -------------YHANDYCMAAGSVPLANNSFLCPNH-----------FTPRK---GCKN---- 1384

  Fly  1066 RVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCA 1130
                            .|::|.:...:.:..|:     ||.|:  |.|                |
Zfish  1385 ----------------HEHINVSWCFVCSEGGS-----LLCCE--SCP----------------A 1410

  Fly  1131 VMNEKCDMLNLFLQ-----CGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLS 1190
            ..:.:|  ||:.:.     |....|.|.|..|..|.:.            |..||          
Zfish  1411 AFHREC--LNIEMPQGSWFCNDCRAGKKPHYKDILWVK------------VGRYR---------- 1451

  Fly  1191 FIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTV 1255
                     |    |.||     :.:..|:|:.:                               
Zfish  1452 ---------W----WPAE-----VTQPKSVPENI------------------------------- 1467

  Fly  1256 LHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQ 1320
                                   ..:::..|:.|:|              .....|.:...:|. 
Zfish  1468 -----------------------SRMKHEVGEFPVH--------------FFGSKDYVWTYQAR- 1494

  Fly  1321 LPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEA 1385
                |.|..|.:....          ..:|.....|...|.|....|..::::.:......||..
Zfish  1495 ----CFPYMEGDANNK----------EKMGKGADAVYKKALNEAADRFRELLKEKEMRQLQEDRK 1545

  Fly  1386 DSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADF 1450
            :....|.:::          :::::::.::.|.:. |.....||.|..       |.|:....|.
Zfish  1546 NDKKPPPYKH----------IKVNKQIGKVLIITA-DLSEIPRCNCKA-------TDENPCGIDS 1592

  Fly  1451 NYEDPAVIFEC-NDVCGCNQLSCKNRVVQNGTRTPLQIVECE---DQAKGWGVRALANVPKGTFV 1511
            ...:..:::|| :.||...: .|     ||.:.|..|..|.|   ..::|||:|:::::.||.||
Zfish  1593 ECINRMLLYECHSQVCPAGE-RC-----QNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFV 1651

  Fly  1512 GSYTGEILTAMEADRRTDDS--------YYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVF 1568
            ..|.||::...|...|..::        |...||....|||...||.:||.||||:||.      
Zfish  1652 NEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNC------ 1710

  Fly  1569 YEHQDYRF---PKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVG-----CRCLTTTCKYASQS 1625
             |.|.:..   .::..|:..||..|.|:.|:|        :..|:|     |:|....|......
Zfish  1711 -ETQKWTVNGDTRVGLFALEDIPKGVELTFNY--------NLECLGNGKTVCKCGAPNCSGFLGV 1766

  Fly  1626 SSTNASPTNATT 1637
            ...|..|::..|
Zfish  1767 RPKNQPPSDDKT 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 16/97 (16%)
Ank_2 1056..1152 CDD:289560 15/100 (15%)
ANK 1088..1217 CDD:238125 23/133 (17%)
ANK repeat 1088..1120 CDD:293786 6/31 (19%)
ANK repeat 1124..1153 CDD:293786 6/33 (18%)
Ank_2 1127..1249 CDD:289560 19/126 (15%)
ANK 1155..1306 CDD:238125 14/150 (9%)
ANK repeat 1155..1196 CDD:293786 5/40 (13%)
ANK repeat 1199..1249 CDD:293786 6/49 (12%)
Ank_2 1205..1316 CDD:289560 9/110 (8%)
ANK repeat 1251..1283 CDD:293786 0/31 (0%)
ANK repeat 1285..1316 CDD:293786 4/30 (13%)
PreSET 1357..1466 CDD:128744 17/109 (16%)
SET 1495..1602 CDD:214614 38/117 (32%)
nsd1aXP_683890.4 PWWP 285..382 CDD:295359 16/99 (16%)
TNG2 <1108..1270 CDD:227367 34/173 (20%)
PHD1_NSD1_2 1228..1270 CDD:277118 7/49 (14%)
PHD_SF 1275..1321 CDD:304600 10/65 (15%)
PHD3_NSD1 1322..1375 CDD:277123 15/106 (14%)
PHD4_NSD1 1392..1431 CDD:277126 11/63 (17%)
WHSC1_related 1437..1531 CDD:99899 25/216 (12%)
AWS 1574..1624 CDD:197795 14/62 (23%)
SET 1626..1748 CDD:214614 41/136 (30%)
PHD5_NSD1 1802..1844 CDD:277129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593822
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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