DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and NSD3

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_075447.1 Gene:NSD3 / 54904 HGNCID:12767 Length:1437 Species:Homo sapiens


Alignment Length:1677 Identity:315/1677 - (18%)
Similarity:516/1677 - (30%) Gaps:617/1677 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 KEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDS 130
            |..:|..|:.: .:|..|:::         |.|.:|    |||.  :.|.||             
Human   159 KTIQNGRELFE-SSLCGDLLN---------EVQASE----HTKS--KHESRK------------- 194

  Fly   131 EMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQ 195
            |..||.|        |.:|:...|:.:.:|.....|.....:.:.:..::|   ..|||:|    
Human   195 EKRKKSN--------KHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEK---PREEPVL---- 244

  Fly   196 KLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRS 260
            |.||..:|:.:       :.|....|..||.........:..|......:...:.|:        
Human   245 KEEAPVQPILS-------SVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQL-------- 294

  Fly   261 RRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVR----LQLKSEPDKP 321
                          :.|.::..:   .:.:|     |::.|:.....|.|.    .:.|......
Human   295 --------------EVHTKINTR---GAREY-----HVQFFSNQPERAWVHEKRVREYKGHKQYE 337

  Fly   322 SLTALSPEENSAPAPKRGRGRARKIRPDAEVETSEV-ILPCEDSLGEKKPGRKR--------KLP 377
            .|.|.:.::.|..:.|:   :.||.||..|....:: |...|.:|...:..|..        |.|
Human   338 ELLAEATKQASNHSEKQ---KIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQP 399

  Fly   378 DEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAE 442
            :|.:.|.:.|  |..|||           ||:.||                  ....|:.||. :
Human   400 EEALSQAKKS--VASKTE-----------VKKTRR------------------PRSVLNTQPE-Q 432

  Fly   443 LSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSC---GLPFANGNKKTNSSGGCELQ 504
            .:..||.|.:....:............:.:.|.||:..:|:.   .||.:    .|...|..:||
Human   433 TNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPAS----ITMHKGSLDLQ 493

  Fly   505 LPKRSKRRIKPTPKI-----LENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSST 564
                 |..:.|..||     |:|    ...:.|.|::...  |...:....|....|.:....||
Human   494 -----KCNMSPVVKIEQVFALQN----ATGDGKFIDQFVY--STKGIGNKTEISVRGQDRLIIST 547

  Fly   565 SRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIK 629
            ..|:::|...|     ...|..||.....:..|.||                         ..|:
Human   548 PNQRNEKPTQS-----VSSPEATSGSTGSVEKKQQR-------------------------RSIR 582

  Fly   630 ASRINANRSPE---ERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRV 691
             :|..:.:|.|   ::|:.|:|...:.:...|    .||||. ..|.||:               
Human   583 -TRSESEKSTEVVPKKKIKKEQVETVPQATVK----TGLQKG-ASEISDS--------------- 626

  Fly   692 QVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDA 756
              .||                   ||.|               :||:.:|...:.|....|..|:
Human   627 --CKP-------------------LKKR---------------SRASTDVEMTSSAYRDTSDSDS 655

  Fly   757 -----------EQLHSLDTSIQADVTPIRDLDMRPSTSR----VSKFICLCQKPSQYYARNAPDS 806
                       :|:.|...:..|||:.::.:|  .|.||    :||...:||..........|..
Human   656 RGLSDLQVGFGKQVDSPSATADADVSDVQSMD--SSLSRRGTGMSKKDTVCQICESSGDSLIPCE 718

  Fly   807 SYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIF------ 865
            ..||...|::      |..|:|      .|..:    .:|.|.|   ...:.|..|.:.      
Human   719 GECCKHFHLE------CLGLAS------LPDSK----FICMECK---TGQHPCFSCKVSGKDVKR 764

  Fly   866 CTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCP-HC------GLD 923
            |:.|   .|.:  |:|..|.::|..:..        |.:|         .:|| ||      ..|
Human   765 CSVG---ACGK--FYHEACVRKFPTAIF--------ESKG---------FRCPQHCCSACSMEKD 807

  Fly   924 TPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKG---GLSTA 985
            ..:.:....|:|...||...:....|....:..||::. ..:..:..:..::|.|.|   ..:..
Human   808 IHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYIL-ICSNHSKRSSNSSAVNVGFCFVCARG 871

  Fly   986 VTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQL-----IPESVMNVVLRGHVVSASGR 1045
            :.:...|.|...:...:          |.:.||..|.|:|     ||.|           |||.:
Human   872 LIVQDHSDPMFSSYAYK----------SHYLLNESNRAELMKLPMIPSS-----------SASKK 915

  Fly  1046 VTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGA 1110
                             ..|:...:|..:                               .|..:
Human   916 -----------------KCEKGGRLLCCE-------------------------------SCPAS 932

  Fly  1111 SSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLH----IAAQLGNLEA 1171
            ..|:.::|            .|.|.|...|   .|.|        || .||    :..:|||   
Human   933 FHPECLSI------------EMPEGCWNCN---DCKA--------GK-KLHYKQIVWVKLGN--- 970

  Fly  1172 TQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFIS 1236
                   ||                   |    |.||:.:         |::|.|          
Human   971 -------YR-------------------W----WPAEICN---------PRSVPL---------- 986

  Fly  1237 FLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVE---GDTPLHIACRHSV 1298
                                                       |:|.::   ||.|:.....|  
Human   987 -------------------------------------------NIQGLKHDLGDFPVFFFGSH-- 1006

  Fly  1299 TRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASNG 1363
                        |....::....|:  :..::|........|           :||....:.:  
Human  1007 ------------DYYWVHQGRVFPY--VEGDKSFAEGQTSIN-----------KTFKKALEEA-- 1044

  Fly  1364 REARPIQVVRNELAMSEN-EDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSD 1427
              |:..|.::.:....|. |.|.:|...|.:::     |:.|.|     :.:::| ...|.....
Human  1045 --AKRFQELKAQRESKEALEIEKNSRKPPPYKH-----IKANKV-----IGKVQI-QVADLSEIP 1096

  Fly  1428 RCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPLQIVECE 1491
            ||.|..|...........||....|       ||: .||.... .|:|:..........:|::.|
Human  1097 RCNCKPADENPCGLESECLNRMLQY-------ECHPQVCPAGD-RCQNQCFTKRLYPDAEIIKTE 1153

  Fly  1492 DQAKGWGVRALANVPKGTFVGSYTGEILTAMEA--------DRRTDDSYYFDLDNGHCIDANYYG 1548
              .:|||:|...::.||.||..|.||::...|.        :....:.|...:.....|||...|
Human  1154 --RRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKG 1216

  Fly  1549 NVTRFFNHSCEPNVLPVRVFYEHQDYRF---PKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCV 1610
            |.:||.||||.||.       |.|.:..   .::..|:..||.||.|:.|:|        :..|:
Human  1217 NYSRFMNHSCNPNC-------ETQKWTVNGDVRVGLFALCDIPAGMELTFNY--------NLDCL 1266

  Fly  1611 G-----CRCLTTTCKYASQSSSTNASPTNATTAPENETGTLSSTNTEKIGHA 1657
            |     |.|....|     |......|.:|          .:|||.||..:|
Human  1267 GNGRTECHCGADNC-----SGFLGVRPKSA----------CASTNEEKAKNA 1303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 17/97 (18%)
Ank_2 1056..1152 CDD:289560 11/95 (12%)
ANK 1088..1217 CDD:238125 22/132 (17%)
ANK repeat 1088..1120 CDD:293786 3/31 (10%)
ANK repeat 1124..1153 CDD:293786 6/28 (21%)
Ank_2 1127..1249 CDD:289560 22/125 (18%)
ANK 1155..1306 CDD:238125 22/157 (14%)
ANK repeat 1155..1196 CDD:293786 9/44 (20%)
ANK repeat 1199..1249 CDD:293786 7/49 (14%)
Ank_2 1205..1316 CDD:289560 13/113 (12%)
ANK repeat 1251..1283 CDD:293786 1/31 (3%)
ANK repeat 1285..1316 CDD:293786 5/33 (15%)
PreSET 1357..1466 CDD:128744 22/110 (20%)
SET 1495..1602 CDD:214614 36/117 (31%)
NSD3NP_075447.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..252 25/104 (24%)
PWWP domain; Pfam PF00855 264..324 10/89 (11%)
MSH6_like 267..383 CDD:99898 22/148 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..365 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..465 15/90 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..696 46/244 (19%)
TNG2 <602..746 CDD:227367 43/217 (20%)
PHD type zinc finger motif 697..738 12/52 (23%)
PHD1_NSD3 703..746 CDD:277119 12/58 (21%)
PHD type zinc finger motif 745..795 12/74 (16%)
PHD2_NSD3 751..797 CDD:277122 13/67 (19%)
PHD3_NSD3 798..850 CDD:277125 9/52 (17%)
PHD type zinc finger motif 858..945 23/167 (14%)
PHD4_NSD3 917..952 CDD:277128 9/80 (11%)
PWWP domain; Pfam PF00855 954..1013 24/176 (14%)
WHSC1_related 958..1051 CDD:99899 28/218 (13%)
AWS 1094..1144 CDD:197795 13/57 (23%)
SET 1145..1268 CDD:214614 39/139 (28%)
SET domain 1149..1255 34/114 (30%)
PHD type zinc finger motif 1317..1364
PHD5_NSD3 1323..1365 CDD:277131
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158044
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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