DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and ehmt1b

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_021324462.1	Gene:	ehmt1b / 402830	ZFINID:	ZDB-GENE-080515-3	Length:	1295	Species:	Danio rerio

Alignment Length:	1606	Identity:	416/1606 - (25%)
Similarity:	642/1606 - (39%)	Gaps:	413/1606 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 IEEEGRKEMEYDQDVAKQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKT 175
            ::.||.||...||:....|..    |:|:...:      .|..|::.|         :||...|.
Zfish    31 MKSEGTKESRSDQEEGGDDDH----QDGRTGPL------REAIEQNGT---------YENMDTKR 76

  Fly   176 EQQNKKAAEKEEEPI-----LAATQ-----KLEANAEPLTTTRIEVAVASPLVVSSASVKLAADA 230
            .:||.........|.     |:.|:     |:.:|...|:..: |..|::|            ..
Zfish    77 NEQNLSTQGSPARPSTMENGLSETEPPHGSKVGSNGYILSKVK-EDTVSAP------------HR 128

  Fly   231 TNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCS 295
            ||.    :..|..||..        ||:.|         |.||..
Zfish   129 TNW----SPTGGTTLGH--------GTKSS---------PPSVLQ-------------------- 152

  Fly   296 SHLERFTLDDNTAIVRLQLKSEPDKPSLTALSPEE-------NSAPAPKRGRGRARKIRPDAEVE 353
                  :||..::     .......||||....|.       :..|.|...|.|....|| |..:
Zfish   153 ------SLDQGSS-----NSGASQGPSLTERRAETETKNGIISKTPPPTVHRARKTMSRP-ASNQ 205

  Fly   354 TSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGN 418
            |.:::            .|:.|.|            ||||.:
Zfish   206 TLKLL------------NRENKEP------------VVVKDD----------------------- 223

  Fly   419 RLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETS 483
               :.|.|      ||:.||||       :....||.:..|..:.|.....|   |.::.....|
Zfish   224 ---SAGKP------EAVQPQPS-------LIQNQLPQSQTDATSVPNTTPAK---PQIEFSLYAS 269

  Fly   484 CGLP-------FANGNKKTNSSGGCELQLPKRSKRRIK---------------PTPKILENDELR 526
            ...|       .|...||....|...| :||:..:.:|               |.||
Zfish   270 TVEPRPVSPSVAAVSRKKKRKMGTYSL-VPKKKNKVLKQRTVLEMFQQISQSPPNPK-------- 325

  Fly   527 CEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIK 591
                .|.|.|:                    ||........:.:..:|.:.|.           :
Zfish   326 ----PKEIVRV--------------------NGEKMDNESDEEESEEGEDTED-----------E 355

  Fly   592 KRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQRKLAKQK 656
            :.|.::.       ||.  |..:.|..|.:.|.|.:......:.....|..:.:...:..|.|:.
Zfish   356 EELVTED-------GAK--ASHEEPRIPSISQPLEEESEESQDCEGEEEGDESDLSSESSLKKKW 411

  Fly   657 EKHLK--HLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQ-----VGKPSVTLRVRNSVTKELPTTA 714
            :|..|  |..|:.:.:.:  ....:.||....|.|.:|     ...|||....|... ||:|..:
Zfish   412 KKKAKGDHAWLRPSRKRK--RKWKAKTDKVSAPVTEIQSRPESQSAPSVPTAHRKEY-KEVPLDS 473

  Fly   715 TLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMR 779
            .     |...|.|.||           ::...||..:.:.||:.:..|         |:....|.
Zfish   474 L-----NLAAQEALLT-----------SQNTAASGSLQSTDADMVQEL---------PLCSCRME 513

  Fly   780 PSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMI 844
            ...||  :.:.|..:.             |.|.:.||.|...|.:.:..  |.::|||..|..::
Zfish   514 TPKSR--EILTLADRK-------------CMATESIDGQLSRCQSAVLK--HEMMRPSNSVQLLV 561

  Fly   845 LCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQ----HFFHPDCAQRFILSTSYEKELGDEEDQG 905
            ||::|:..:..|.||.|||.||..|.|:.|:.:    |.||..||.  :|:             |
Zfish   562 LCEDHRTGMVKHQCCPGCGFFCRAGTFMECQPEVNISHRFHRTCAS--VLN-------------G 611

  Fly   906 VKFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENAN 970
            ..|        |||||    |..|             :.::..|..|..|::..:|....:. :.
Zfish   612 QSF--------CPHCG----EEVS-------------KAKEVTIAKADTTSTVPITHSSCIP-ST 650

  Fly   971 TPGATARNKGGLSTAVTL---SAASSPASKTNGAQRGRAGTSNSNSRH-ALNSINFAQLIP---- 1027
            :.|......|| ||.:::   ..|:|...|.:.:|........|.:|. |:.:.....|.|
Zfish   651 SEGKADTTTGG-STRLSVLGEGKANSTLPKPSESQDTSLSLVGSKARSVAMAAAPGLPLPPGPPK 714

  Fly  1028 ESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHL 1092
            |::.:|:|   .:.|.......|.|:.:|.:.:..:|::|..:|....:....:......|.||:
Zfish   715 ETLQSVLL---ALDAEKPKKLRFHPKQLYISAKQGELQKVLLMLVDGIDPNFKMESQNKRTPLHV 776

  Fly  1093 VAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGK 1157
            .|.:|...:.::|:..||:    :::.|.:.||.||.|..|...:.:...|:.||.|:.|..:|.
Zfish   777 AAEAGHQDVCHMLVQAGAN----LDMCDEDQRTPLMEACENNHLETVRYLLRAGAIVSHKDVEGS 837

  Fly  1158 TSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQ 1222
            |.||:||:.|:....|.:         :::.|..|:.||:||||||:||.|..|.|.|:|
Zfish   838 TCLHLAAKNGHFSIVQHL---------LSAGLVDINCQDDGGWTAMIWATEYKHVDQVKL----- 888

  Fly  1223 AVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGD 1287
                           ||::.||.||.|.:.|..|||:.. :..::...:.|.:..|.|..|:.||
Zfish   889 ---------------LLSKGADINIRDKEENICLHWAAF-SGCVEIAEIFLTAKCDLNTMNIHGD 937

  Fly  1288 TPLHIACRHSVTRM-CIAL-IANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLG 1350
            :|||||.|..  |: |:.| ::.|||:.:|||..:.|.:|..:.............|..:.|..|
Zfish   938 SPLHIASREG--RLDCVNLFLSRGADVNLKNKEGETPMECCSHSSKVWNALQANKKQREANRKAG 1000

  Fly  1351 LRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPD-FRYV-TQCIIQQNSVQIDRRVS 1413
            ....::..|.:.|.|..|:..|          :..||...|| ::|| ..|:  .:.:.||:.::
Zfish  1001 ATEKLLNKDIARGYEKVPVPCV----------NAVDSEPCPDNYKYVPDSCV--TSPLNIDKNIT 1053

  Fly  1414 QMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQ 1478
            .::.|.|.|.|||..|.|...|.:.||..||||..:|:.|:|.:|||||..|.|.: :|||||||
Zfish  1054 HLQYCVCKDDCSSASCMCGQLSLRCWYDKESRLLPEFSNEEPPLIFECNHACSCWR-TCKNRVVQ 1117

  Fly  1479 NGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDNG---- 1539
            ||.||.||:.  :.|..||||:.|.::|:||||..|.|||::..|||.|.:|||.|.||:.
Zfish  1118 NGLRTRLQLF--KTQMMGWGVKTLQDIPQGTFVCEYVGEIISDAEADVRENDSYLFSLDSKVGDM 1180

  Fly  1540 HCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRV 1604
            :|:||.:|||::||.||.||||:||.|||..|||.|||.||||:|::|.||:|:.||||:.||.|
Zfish  1181 YCVDARFYGNISRFINHHCEPNLLPCRVFTSHQDLRFPHIAFFACKNISAGDELGFDYGDHFWDV 1245

  Fly  1605 EHRSCVGCRCLTTTCKY-ASQSSSTNASPTNATTAPENETGTLSST 1649
            :.: ...|:|.::.||: |:..:.|.|..|.....|.....|.|||
Zfish  1246 KGK-LFNCKCGSSKCKHSAAAIAQTQADSTPGDQQPSALPDTSSST 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	22/107 (21%)
		Ank_2	1056..1152	CDD:289560	23/95 (24%)
		ANK	1088..1217	CDD:238125	44/128 (34%)
		ANK repeat	1088..1120	CDD:293786	8/31 (26%)
		ANK repeat	1124..1153	CDD:293786	10/28 (36%)
		Ank_2	1127..1249	CDD:289560	40/121 (33%)
		ANK	1155..1306	CDD:238125	51/152 (34%)
		ANK repeat	1155..1196	CDD:293786	10/40 (25%)
		ANK repeat	1199..1249	CDD:293786	18/49 (37%)
		Ank_2	1205..1316	CDD:289560	36/112 (32%)
		ANK repeat	1251..1283	CDD:293786	7/31 (23%)
		ANK repeat	1285..1316	CDD:293786	14/32 (44%)
		PreSET	1357..1466	CDD:128744	37/110 (34%)
		SET	1495..1602	CDD:214614	62/110 (56%)
ehmt1b	XP_021324462.1	Atrophin-1	27..>278	CDD:331285	75/397 (19%)
		Ank_2	739..833	CDD:315466	23/97 (24%)
		ANK repeat	739..765	CDD:293786	4/25 (16%)
		ANK repeat	767..800	CDD:293786	8/36 (22%)
		ANK	797..923	CDD:238125	48/155 (31%)
		ANK repeat	802..833	CDD:293786	10/30 (33%)
		ANK repeat	835..867	CDD:293786	10/40 (25%)
		ANK repeat	869..900	CDD:293786	19/50 (38%)
		ANK repeat	902..933	CDD:293786	7/31 (23%)
		Ank_2	907..>980	CDD:315466	26/75 (35%)
		ANK repeat	935..966	CDD:293786	14/32 (44%)
		Pre-SET	1010..1114	CDD:309948	40/116 (34%)
		SET	1123..1244	CDD:214614	66/122 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593838
Domainoid	1	1.000	148	1.000	Domainoid score	I4410
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	1	1.000	-	-		FOG0003434
OrthoInspector	1	1.000	-	-		otm26147
orthoMCL	1	0.900	-	-		OOG6_105922
Panther	1	1.100	-	-	O	PTHR46307
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X1720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790