DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Kmt2d

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_017172163.1	Gene:	Kmt2d / 381022	MGIID:	2682319	Length:	5608	Species:	Mus musculus

Alignment Length:	2031	Identity:	353/2031 - (17%)
Similarity:	610/2031 - (30%)	Gaps:	727/2031 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDFVELMNSMSSTFNSDCATSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEER 65
            ||...:|...|.|.......::.|.|    :|...:.:..:.:.|...|...::::.:.::::::
Mouse  3890 MTGLSQLQQGMMSHGGQPKMSAQALG----SLQQQQQQLQQQQMLQQQQLQQQQQQLQQQQQQQQ 3950

  Fly    66 KEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDS 130
            .:.:.|::::                |::::.|..:.:: |     :::.:::::..|.:.:|..
Mouse  3951 LQQQQQQQLQ----------------LQQQQQQQQQHLQ-H-----QQQQQQQLQQQQQLQQQQQ 3993

  Fly   131 EM--EKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEE----- 188
            :.  .::|..:...:.::.:......::.|.::....::.:.:..:.:||.::..:::::
Mouse  3994 QQLHLQQQLHQQQQLQLQQQQMGLLNQNRTLLSPQQQQQQQQQQQQQQQQQQQQQQQQQQVTLGP 4058

  Fly   189 -----------------PILAATQKLEANAEPLTTTRI------------EVAVA-SPLVVSSAS 223
                             |.|..|.|.:.|||....:.:            .|..| .|:.|....
Mouse  4059 GLPVKPLQHFSSSGALGPTLLLTGKEQNNAETALPSEVTEGPSTHQGGPPAVGTAPEPMSVEPGE 4123

  Fly   224 VKLAADATNQM-----RAATSAGAATL----------------------ADKNVQVSPGGTRRSR 261
            ||.:....:|:     :|.:.|.:..|                      .....|:..|.:..|.
Mouse  4124 VKPSISGDSQLLLVQSQAQSQATSVQLQPPLRLPGQPQPQVNLLHTAGGGSHGQQLGSGSSSESP 4188

  Fly   262 RTPRPIDTPT-SVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTA 325
            ..|..:..|: |:.::...:.....|..:..     .|:| .:.:||.       |:|.|
Mouse  4189 AVPHLLAQPSVSLGEQPGPMAQNLLGSQQPL-----GLDR-PIQNNTG-------SQPPK----- 4235

  Fly   326 LSPEENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPD----EPIDQQQL 386
                  |.|||:.|:|     .|.|.|      :|....|..:..|...|.|.    .|..||||
Mouse  4236 ------SGPAPQSGQG-----PPGAGV------MPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQL 4283

  Fly   387 SDLVVVKTEQ-----------EELGDAP------LG--------DVKRMRRSVRLGNRLHADGSP 426
            ..|::.:..|           :|.|..|      ||        .|.:......||......|.|
Mouse  4284 QALLMQRQLQQSQAVRQTPPFQEPGTQPSPLQGLLGCQPQPGGFSVSQTGPLQELGAGSRPQGPP 4348

  Fly   427 WEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSCGLPFANG 491
                    ..|.|...||...|.....|       |||....::.|.|. :|.|.::...|...|
Mouse  4349 --------RLPVPQGALSTGPVLGPAHP-------TPPPSSPQEPKRPS-QLPSPSAQLTPTHPG 4397

  Fly   492 NKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEFETKHI------ERMTQW---ESAAAVD 547
            ..|..   |..|:||   ..|:.|...     :|...|..|.:      :.:|:.   |.::.|.
Mouse  4398 TPKPQ---GPALELP---PGRVSPAAA-----QLADTFFGKGLGPWDPSDNLTEAQKPEQSSLVP 4451

  Fly   548 GDFETPTTGGNGSNSSTSRQKSDKSD--------GSNF--EGGPGHPAGTSAIKKRLFSKSQRDI 602
            |..:..    ||.......|.|.|.:        |:..  ....|.|||.......|.....|
Mouse  4452 GHLDQV----NGQVVHEPSQLSIKQEPREEPCALGAQTVKREANGEPAGAPGTSNHLLLAGSR-- 4510

  Fly   603 ENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPE--ERKLNKKQQRKLAKQKEKHLKHLGL 665
            ...|..:|.|            |...|..::.|.|.||  ..::|.....||:..::| |:  |.
Mouse  4511 SEAGHLLLQK------------LLRAKNVQLGAGRGPEGLRAEINGHIDSKLSGLEQK-LQ--GT 4560

  Fly   666 QKNHRDE------PSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVV 724
            ..|..|.      |:........::..|::|.::.|.. .:|...::.|:|....:......|.:
Mouse  4561 SSNKEDAATRKPLPAKPKRVQKTSDRLPSSRKKLRKED-GVRANEALLKQLKQELSQLPLTEPTI 4624

  Fly   725 QA--------------AKLTRRIGARAAGEV------------------TEAARASVPISTPDAE 757
            .|              :..::..||..:|.:                  .....:|:|.:.|.:.
Mouse  4625 TANFSLFAPFGSGCLVSGQSQLRGAFGSGALHTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSV 4689

  Fly   758 QLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGC 822
            |...::     .|||..:|..||..:                 .:|.||..... |..:.:.:..
Mouse  4690 QQKMVN-----GVTPSDELGERPKDT-----------------ASAQDSEGALR-DAAEVKSLDL 4731

  Fly   823 CNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQR 887
            ...|.:..||     |.....:..||..                                |....
Mouse  4732 LAALPTPPHN-----QTEDVRMESDEDS--------------------------------DSPDS 4759

  Fly   888 FILSTSYEKELGDEE-----------DQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVF 941
            .:.::|.|..||:|.           :|..:..|||:.: .|..|                :|||
Mouse  4760 IVPASSPESILGEEAPRFPQLGSGRWEQDNRALSPVIPI-IPRTG----------------IPVF 4807

  Fly   942 LRTQKYKIKPARLTTSSHLTQFGTVENANTPG---ATARNKG-GLSTAVTLSAASSPASKTNGAQ 1002
            ..|:.|                 .|.:...||   |||..|| |...:|.|:.:::.|...||..
Mouse  4808 PDTKPY-----------------GVLDLEVPGKLPATAWEKGKGSEVSVMLTVSAAAAKNLNGVM 4855

  Fly  1003 RGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERV 1067
                             :..|:|:...:.|..   .|:...|...|...|:           :..
Mouse  4856 -----------------VAVAELLSMKIPNSY---EVLFPDGPARAGLEPK-----------KGE 4889

  Fly  1068 AEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGA-SSPDFVNIVD-----YELRTA 1126
            ||.....       .:.|:|                    ||. :.||::...|     |.|::.
Mouse  4890 AEGPGGK-------EKGLSG--------------------KGPDTGPDWLKQFDAVLPGYTLKSQ 4927

  Fly  1127 LMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLH--IAAQLGNLEATQLIVDSYRTSRNITSFL 1189
            |         |:|:|..|       :.|..:.|:.  ....:.||:..||............|.|
Mouse  4928 L---------DILSLLKQ-------ESPAPEPSIQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPL 4976

  Fly  1190 S----------FIDAQDEGGWTAMVWAAELGHTDIVRLASLPQA--------------------- 1223
            :          .::.|.|.       .||......:.|||.|::
Mouse  4977 APSPASPPAEPMVELQAER-------PAEPPIPSPLPLASSPESARPKPRARPPEESEDSRPPRL 5034

  Fly  1224 -----VFLKLINIFLFISFLLNQDAD----------------PNICDNDN--------------- 1252
                 |..|.:.:.|.|........|                |:....||
Mouse  5035 KKWKGVRWKRLRLLLTIQKGSGHQEDEREVAEFMEQFGTALRPSKVPRDNRRCCFCHEEGDGATD 5099

  Fly  1253 ----------------NTVLHWST----------------LHNDGLDTITVLLQSGADCNVQNVE 1285
                            |..| |||                ||...|...::..::||..:...:.
Mouse  5100 GPARLLNLDLDLWVHLNCAL-WSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMR 5163

  Fly  1286 GDTPLHIACR-----------------HSVTRMCIALIANGADL----MIKNKAEQLPFDCIPNE 1329
            .....|.||.                 |.:...|...:::.|..    :.:::.:|:.......|
Mouse  5164 CPNVYHFACAIRAKCMFFKDKTMLCPVHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGE 5228

  Fly  1330 ESECGRTVGFNM---------QMRSFR------PLG---------LRT------FVVCADASNGR 1364
            .....|..|...         ||..|.      |:|         |||      :......:|||
Mouse  5229 RLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSISENNGR 5293

  Fly  1365 EARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQ--------------- 1414
            ....|:|:...|......|.:...:|.  |.:......:....:.|...:
Mouse  5294 PEFVIKVIEQGLEDLVFTDASPQAVWN--RIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAV 5356

  Fly  1415 MRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNY------EDPAVIFECNDVCGCNQLSCK 1473
            :||...|....|  ||                |..|.|      |.|.:|    :..||.:...|
Mouse  5357 LRIAESLPGVES--CQ----------------NYLFRYGRHPLMELPLMI----NPTGCARSEPK 5399

  Fly  1474 ------------------NRVVQ------------------NGTRTPL--QIVE----------- 1489
                              |.:::                  ..|.||.  |.|.
Mouse  5400 ILTHYKRVFTSIISFDPHNNLMRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRT 5464

  Fly  1490 --------CEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDSYYFDLDNG 1539
                    ...:.:|.|:.|..::.|.|.|..|.|.|:....|:||       ....|.|.::|.
Mouse  5465 EWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNE 5529

  Fly  1540 HCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRV 1604
            |.|||...|...|:.||||.||.:...|.::.:|    ||...|.|.|..|||:.:||...|...
Mouse  5530 HVIDATLTGGPARYINHSCAPNCVAEVVTFDKED----KIIIISSRRIPKGEELTYDYQFDFEDD 5590

  Fly  1605 EHRSCVGCRCLTTTCK 1620
            :|:  :.|.|....|:
Mouse  5591 QHK--IPCHCGAWNCR 5604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	20/159 (13%)
		Ank_2	1056..1152	CDD:289560	16/101 (16%)
		ANK	1088..1217	CDD:238125	24/146 (16%)
		ANK repeat	1088..1120	CDD:293786	4/32 (13%)
		ANK repeat	1124..1153	CDD:293786	5/28 (18%)
		Ank_2	1127..1249	CDD:289560	27/175 (15%)
		ANK	1155..1306	CDD:238125	38/268 (14%)
		ANK repeat	1155..1196	CDD:293786	7/52 (13%)
		ANK repeat	1199..1249	CDD:293786	12/91 (13%)
		Ank_2	1205..1316	CDD:289560	30/220 (14%)
		ANK repeat	1251..1283	CDD:293786	12/78 (15%)
		ANK repeat	1285..1316	CDD:293786	6/51 (12%)
		PreSET	1357..1466	CDD:128744	22/129 (17%)
		SET	1495..1602	CDD:214614	39/113 (35%)
Kmt2d	XP_017172163.1	ePHD1_KMT2D	134..217	CDD:277165
		PHD1_KMT2C_like	228..273	CDD:276984
		PHD_SF	275..320	CDD:389947
		PHA03247	<492..883	CDD:223021
		PHD3_KMT2D	1335..1385	CDD:277072
		PHD5_KMT2C_like	1386..1432	CDD:276988
		PHD5_KMT2D	1463..1513	CDD:277074
		HMG	1982..2033	CDD:197700
		PHA03247	<2071..2637	CDD:223021
		PHA03247	<4089..4434	CDD:223021	81/406 (20%)
		ePHD2_KMT2D	5087..5193	CDD:277168	14/106 (13%)
		FYRN	5236..5287	CDD:368685	9/50 (18%)
		FYRC	5295..5382	CDD:197781	16/106 (15%)
		SET_KMT2D	5453..5607	CDD:380986	44/158 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930