Protein Alignment G9a and Ehmt2

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_006256016.3
• Gene: Ehmt2 / 361798
• RGDID: 1302972
• Length: 1394
• Species: Rattus norvegicus
• Alignment Length: 1445
• Identity: 406/1445 - (28%)
• Similarity: 614/1445 - (42%)
• Gaps: 316/1445 - (21%)

  Fly   318 PDKPSLTALSPEENSAP--------------AP-----------KRGRGRARKI--RPDAEVETS 355
            |..|.|.|  ||....|              ||           .|||||.|.:  .|.|:...:
  Rat   112 PPPPLLPA--PEMRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWA 174

  Fly   356 EVI--------LPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRR 412
            ..:        :||..|.||..                 :::..:..|:|     |.|..:|:..
  Rat   175 PQLPAGLTGPPVPCLPSQGEAP-----------------AEMGALLLEKE-----PRGAAERVHG 217

  Fly   413 SVRLGNRLHADGSPWEEVKTEALHP---QPSAELSFAEVTSEILPLAVLDE--KTPPKKRGRKAK 472
            |  ||:..|:     ||...:| :|   :|:...|.|.||     :.|.||  .||      ...
  Rat   218 S--LGDTSHS-----EETLPKA-NPDSLEPTGPSSPASVT-----VTVGDEGADTP------VGA 263

  Fly   473 TPCVKLESETSCG----LPFANGNKKTNSS----GGCELQLPKRSKRRIK---PTPKILENDELR 526
            ||.:..|.|...|    :...:..|...||    |.|    |.|:|..:.   .:|..:::..:|
  Rat   264 TPLIGEEPENLEGDGGRILLGHATKSFPSSPSKGGAC----PSRAKMSMTGAGKSPPSVQSLAMR 324

  Fly   527 CEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAG----- 586
                   :..|...:.||....:....||.|........|.:...|..||  |.|..|..
  Rat   325 -------LLSMPGAQGAATAGPEPPPATTAGQEGQPKVHRARKTMSKPSN--GQPPVPEKRPPEV 380

  Fly   587 --------------TSAIKKRLFSKSQRDIENYGAA------MLAKSKLPPCPDVEQFLNDIKA- 630
                          ||.:.||....|....|:.|:|      :|.|.:..|..:.|..:.|..:
  Rat   381 QHFRMSDDMHLGKVTSDVAKRRKLTSGSLSEDLGSAGGSGEVILEKGEPRPLEEWETVVGDDFSL 445

  Fly   631 --------SRINANRSPE----ERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDN 683
                    .|::::...|    ..:|:::::.:..:::|:..:....::...||.|.|.|..:.:
  Rat   446 YYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGS 510

  Fly   684 EFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARAS 748
                         |...:.:....|:.|.....:.||......||..|  |....|....:....
  Rat   511 -------------SGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPR--GVNGVGSSGPSEYME 560

  Fly   749 VPIST---PDAEQLHSLDTSIQADVTPI---RDLDMRPSTSRVSKFICLCQKPSQYYARNAPDSS 807
            ||:.:   |....|......:..|.:.:   |..:..|        :|.|:..:....|.:..:.
  Rat   561 VPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELP--------LCSCRMEAPKIDRISERAG 617

  Fly   808 Y-CCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKF 871
            : |.|.:.:|.:.:||...:..  ...:|||.||:.|:||:.|:.|:..|:||.|||.|||.|.|
  Rat   618 HKCMATESVDGELLGCNAAILK--RETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTF 680

  Fly   872 VLC----KQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPER----- 927
            :.|    :..|.||..|..:.               .|:.|        |||||.|..|.
  Rat   681 LECHPDFRVAHRFHKACVSQL---------------NGMVF--------CPHCGEDASEAQEVTI 722

  Fly   928 ------TSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGL---- 982
                  |..|.....:.|.....     .|.|..||.             |.|..|..|..
  Rat   723 PRGDGGTPPVGTVAPAPPPLAHD-----APGRADTSQ-------------PSARMRGHGEPRRPP 769

  Fly   983 --STAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGR 1045
              ..|.|:.::....:..||......|......|.||..   |.:|.||..   |.....|...|
  Rat   770 CDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEK---ALVIQESES---LPSPPPSPGRR 828

  Fly  1046 VTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGA 1110
            ....|.||.:|.:|:..:|::|..:|..:.:......:....|.||..|..|::::.::||..||
  Rat   829 KKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGA 893

  Fly  1111 SSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLI 1175
            :    :|.||.:.||.||.||:|...::....:|.|..|..|..||.|.||.||::||||...|:
  Rat   894 N----INAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 954

  Fly  1176 VDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLLN 1240
            :.:.:..         ::|||.||||.::||||..|.|::|:                    ||.
  Rat   955 LSTGQVD---------VNAQDSGGWTPIIWAAEHKHIDVIRM--------------------LLT 990

  Fly  1241 QDADPNICDNDNNTVLHWSTLHNDGLDTIT-VLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIA 1304
            :.||..:.||:.|..|||::.  .|...|. |||.:..|.:..|..||||||||.|.|.....:.
  Rat   991 RGADVTLTDNEENICLHWASF--TGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLL 1053

  Fly  1305 LIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLG-----LRT-FVVCADASNG 1363
            .::.||:..::||.....:|..| |.|:    |.|.:|:.....||     :|| .::|.|.:.|
  Rat  1054 FLSRGANPELRNKEGDTAWDLTP-ERSD----VWFALQLNRKLRLGVGNRAVRTEKIICRDVARG 1113

  Fly  1364 REARPIQVVRNELAMSENEDEADSLMWP-DFRYVTQ-CIIQQNSVQIDRRVSQMRICSCLDSCSS 1426
            .|..||..|..          .|....| |::|::: |  :.:::.|||.::.::.|:|:|.|||
  Rat  1114 YENVPIPCVNG----------VDGEPCPEDYKYISENC--ETSTMNIDRNITHLQHCTCVDDCSS 1166

  Fly  1427 DRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECE 1491
            ..|.|...|.:.||..:.||..:||..:|.:|||||..|.|.: ||||||||:|.:..||:..
  Rat  1167 SNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWR-SCKNRVVQSGIKVRLQLYR-- 1228

  Fly  1492 DQAK-GWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDNG----HCIDANYYGNVT 1551
             .|| |||||||..:|:|||:..|.||:::..|||.|.||||.|||||.    :||||.||||::
  Rat  1229 -TAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNIS 1292

  Fly  1552 RFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLT 1616
            ||.||.|:||::|||||..|||.|||:|||||.|||..|||:.||||::||.::.:... |:|.:
  Rat  1293 RFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFT-CQCGS 1356

  Fly  1617 TTCKYASQSSSTNAS 1631
            ..||:::::.:...|
  Rat  1357 EKCKHSAEAIALEQS 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412
		EHMT_ZBD	786..933	CDD:411018	45/162 (28%)
		ANKYR	1063..1322	CDD:440430	83/259 (32%)
		ANK repeat	1088..1120	CDD:293786	10/31 (32%)
		ANK repeat	1124..1153	CDD:293786	10/28 (36%)
		ANK repeat	1155..1196	CDD:293786	13/40 (33%)
		ANK repeat	1199..1249	CDD:293786	14/49 (29%)
		ANK repeat	1251..1283	CDD:293786	10/32 (31%)
		ANK repeat	1285..1316	CDD:293786	12/30 (40%)
		SET_EHMT	1391..1622	CDD:380941	117/237 (49%)
Ehmt2	XP_006256016.3	None