DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment G9a and set-25

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_499738.3	Gene:	set-25 / 3565129	WormBaseID:	WBGene00012802	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	106/392 - (27%)
Similarity:	157/392 - (40%)	Gaps:	120/392 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1332 ECGRTVGFNMQMRSFRPLGLRT----------FVVCADASNGRE-----------------ARPI 1369
            ||.||....::..|.|...:.|          .||..:..||.|                 :.|.
Worm   332 ECARTAPTILEEMSIRDKFIETVKSAAAEEAKLVVEKNQENGIELTLDEALKQIFIEPVPQSSPE 396

  Fly  1370 QV--VRNELAMSENEDEADSLMWPDFRYV---TQCI-------IQQNSVQID--RRVSQMRICSC 1420
            .|  :..:|:.....|..|..:.|.| |:   ||.:       ...|.|.:|  :|        |
Worm   397 NVFWIYQDLSYFHTMDNRDLGLAPVF-YISSYTQSVRPPCYAYTAINIVDVDAYKR--------C 452

  Fly  1421 LDS----------------------C-SSDRCQCNGASSQNWY----------TAESRLN-ADFN 1451
            |:|                      | :..:|:|: |.....|          |.:.::: .||.
Worm   453 LESRANMSFADLTGQKIWMPTRSKACENGTKCKCD-ARFMFLYDPHDVTNLECTPDGKVDFTDFK 516

  Fly  1452 YEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTG 1516
            .::..::.||:|.|||: |.|..|.:|.|.:.|| .|..|...||:||||.||:..|..|..|||
Worm   517 IDNARIVMECSDACGCS-LDCPRRSLQRGQQHPL-AVYYEGPEKGFGVRAAANIKAGELVCEYTG 579

  Fly  1517 EILTAM----------------------EADRRTDDSY---YFDLDNGHCIDANYYGNVTRFFNH 1556
            :: |.:                      ||..|.|.||   :..:|....|.|...||::||.||
Worm   580 DV-TLLPTSDPVASSSTKTDDGEEQENPEAPERVDSSYDAAFNAMDTKIIISAKKTGNISRFINH 643

  Fly  1557 SCEPNVLPVRVFYE--HQDYRFPKIAFFSCRDIDAGEEICFDYGEK--FWRVEHRSCVGCRCLTT 1617
            ||:|:.:.|.|:..  .:|...|::|.::.:||..||||...|.|.  .|:   ||.|.|||.:|
Worm   644 SCDPSSVFVEVYSRRFEEDPLIPRVAVYAIKDIALGEEITIAYYEPGIEWK---RSSVKCRCKST 705

  Fly  1618 TC 1619
            .|
Worm   706 KC 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744	31/173 (18%)
		SET	1495..1602	CDD:214614	45/135 (33%)
set-25	NP_499738.3	SET	559..686	CDD:279228	42/127 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820