DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Setd2

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_038937536.1	Gene:	Setd2 / 316013	RGDID:	1305576	Length:	2543	Species:	Rattus norvegicus

Alignment Length:	1887	Identity:	367/1887 - (19%)
Similarity:	631/1887 - (33%)	Gaps:	576/1887 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DKEEEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQ 123
            ::|||...:..|.::...||..:...|.::....:..:          ||..:||:||:::.:..
  Rat    31 NREEENEAKIENVQKTGFIKGPIFKGVASSRFLPKGTK----------TKVNLEEQGRQKVSFSF 85

  Fly   124 DVAKQDSE--------MEKKQNGKATSITVKMESNERAEKH------ATEIATTSTERWE--NES 172
            .:.|:..:        .||:.:...:..|.:::||.:|:..      |||.::....|.|  ...
  Rat    86 SLTKKTLQNRFFTALSNEKQSDSPHSPATPQVDSNPKAKMEAGDTFPATEESSPPKSRVELGRIH 150

  Fly   173 FKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAA 237
            ||     |........|.||.|..:.:...|  ||::.||:|...|.|..|.........|:  :
  Rat   151 FK-----KHLLHVTSRPQLATTTTVASLLPP--TTQLPVAIAESTVDSPPSSPPPPPPPPQV--S 206

  Fly   238 TSAGAATLADKNVQVSPGGTRRSRRTPRPI---------------------------DTPTSVTD 275
            :.:..|.:::......|..|.....||.|:                           |..::..:
  Rat   207 SPSPPAPISEPVALPHPPVTALMTSTPGPLPVDAAVRAQKEPPMKSVPESLELDMKQDIVSNSLE 271

  Fly   276 EH------------VQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQ--------LKSEPDK 320
            ||            :|.|:...||.|:.:|.|    :.:|....|..:.:        |.||.|:
  Rat   272 EHTNQTLKEQADNALQKEDSHIGKEEEVSDGS----KISLSSKKASSKKKSSQFEGTFLGSESDE 332

  Fly   321 PSL--------------TALSPE----ENSAPAPKRGRGRARKIRPD----------AEVETSEV 357
            .|:              |::..|    ::|||:.....|::.:.:.:          .|.:|..|
  Rat   333 DSVRTSSSQRSHDLKSSTSIEKERDFKKSSAPSKSEDLGKSSRSKTERDDKYFSYSKLERDTRYV 397

  Fly   358 ILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHA 422
            ...|. |..:::..|.|...|. :.:..||   ..::|:....|:.    :|..||
  Rat   398 STRCR-SERDRRRSRSRSRSDR-VSRTSLS---YSRSERSHYYDSE----RRYHRS--------- 444

  Fly   423 DGSPWEEVKTEALHP---QPSAELSFAEVTSEILPLAVLDE--KTPPKKRG----RKAKTPCVKL 478
              ||:.| :|....|   ..:.|.|.:|           ||  ||.|::..    |..:|.....
  Rat   445 --SPYRE-RTRYSRPYTDNRARESSDSE-----------DEYKKTYPRRTSAHSYRDLRTSSSYS 495

  Fly   479 ESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEFETKHIERMTQWESA 543
            :.:..|         ||.:|   .|::.:|.|...|     ||.:..|.. |.:.|:|.....:.
  Rat   496 KFDRDC---------KTETS---YLEMERRGKYSSK-----LERESKRTS-EHEAIKRCCSPPNE 542

  Fly   544 AAVDGDFETPTTGGNGSNSSTSR---------QKSDKSDGS------NFEGGPGHPAGTSAIKKR 593
            ..    |...::.....|:||||         .||||...|      |.|....|
  Rat   543 LG----FRRGSSYSKHDNNSTSRYKSALSKSISKSDKFKNSFCCTELNEENKQSH---------- 593

  Fly   594 LFSKSQRDIENYGAAMLAKSKLP-------PCPDVEQFLNDIKASRINANRSPEERKLNKKQQRK 651
              |.|.:...:.|:.:...:|:|       |.|..:  |||          ||..:||::....|
  Rat   594 --SFSLQTPCSKGSELRTINKIPEREKTGSPSPSNQ--LND----------SPTFKKLDESPILK 644

  Fly   652 ---LAKQKEKHLKHLGLQKNHRD--------EPSDNDSSNTDNEFFPTTRVQVGKP-SVTLRVRN 704
               :.....:.:|.|.|.|...|        |.:.|.|..|:.:   ....:..|| ::::...:
  Rat   645 PEFIGHDSHESIKELELPKMKNDQLRNFCSIELNVNGSPETETD---VATFRTSKPDAISMTSDD 706

  Fly   705 SVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTE---------------AARASVPISTP 754
            |||         .|..:|:::...|:.. |.::.|...|               ..|.:.|:.:|
  Rat   707 SVT---------GSEVSPLIKGCVLSSN-GFQSVGRCRERDADDACRQHNKSKSPFRETEPLLSP 761

  Fly   755 DAEQLHSLDT-SIQADVTPIRD-LDMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDD 817
            ..:::.||.. :|....|.|:: :|.|.|..:.......|.......|.|...||.|....|:|.
  Rat   762 HHDKVMSLPVKTIDYSKTLIKEPVDKRHSCCKTKDSDRYCSPNESSEAENREISSNCFVNVHLDS 826

  Fly   818 QKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHP 882
            :.:.|.|...::.|:          ...||.:|:.:.|.:..:               ..||
  Rat   827 KTVVCDNRELTDQHS----------EFTCDGYKQSIGSTSSAS---------------LNHF--- 863

  Fly   883 DCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTV--TMKCQSLPVFLRTQ 945
                    ...|| .:|         ||.:..|:....|:...|.||..  |::.:....||
  Rat   864 --------DDLYE-SVG---------SSGISSLQSLPSGIRCEENTSPALDTVQSKKGIDFL--- 907

  Fly   946 KYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSN 1010
            ||..|...:.::        :.::....::..|:..:.:..:|..:....|.|...:|||:..|.
  Rat   908 KYVGKETDVVSA--------LPDSGKAFSSWENRHNMLSGQSLQESQEEGSSTLHERRGRSEVSL 964

  Fly  1011 SNSRHALNSINFAQLIPESVMNVVLRGHV-VSASGRVTAEF----TPRD---MYYAVQNDDLERV 1067
            .....                    |||. :|....|...:    |..|   :.|.::.|.....
  Rat   965 DEEEQ--------------------RGHTHISDDSEVVFPYDLNLTMEDSDGVTYTLKCDSSGNA 1009

  Fly  1068 AEILA---ADFNVLTPI------------------REYLNGTCLHLVAHSGTLQMAYLLLCKGAS 1111
            .||::   .|::..:..                  |..|....  :|..:.||.|.....|...|
  Rat  1010 PEIVSTVHGDYSASSASSSDESDSEDTESDDSSIPRNRLQSVV--VVPKNSTLPMEETSPCSSRS 1072

  Fly  1112 SPDFVNIVD------------YELRTALMCAVMNEKCDML-NLFLQCGA---------------- 1147
            |..:.:..|            ||.:...|.   ::.|... ..||..|.
  Rat  1073 SQSYRHYSDHWEDGLESRRHAYEEKFESMA---SKGCSQTEKFFLHKGTERNPETSYSQFSRKID 1134

  Fly  1148 ----DVAIKGPDGKTSLH-----------------IAAQLGNLEATQLIVDSY----RTSRNITS 1187
                ::|....||..|..                 |.|::...:...:..|.:    .|||....
  Rat  1135 NHLPEIAHSQSDGVDSTSHTDVKSDSVGHLNSEDAIRAKMSRPQELPVYCDDFEDLPNTSRQQMI 1199

  Fly  1188 FLSFIDAQDEGGWTAMVWAAELGHT---DIVRLASLPQAVFLKLINIFLFISFLLNQDADPNIC- 1248
            |.:..|:...|       .|||..:   ||.|:..|..:..|:      .:.:..:|...|...
  Rat  1200 FSNRPDSSRLG-------KAELSFSSSCDISRMDGLHSSEELR------NLGWDFSQQERPTTTY 1251

  Fly  1249 ---DNDNNT---------VLHWSTLH-----NDGLDTITVLLQSGADCNVQNVEGDTP------- 1289
               |:...|         ..|:...|     |...|..:.....|.......::|..|
  Rat  1252 QQPDSSYGTCGTHKYQQSAEHYGGTHDYWQGNGYWDPRSAGRPPGTGVVYDRIQGQVPDSLTDDR 1316

  Fly  1290 ----------------------LHIACRHSVTRMCIALIANG-ADLMIKNKAEQLPFDCIPNEES 1331
                                  .|...:.||....|:  :|. .|.::.|:.:....:...|:..
  Rat  1317 EEEENWDQRSGSHFSSPSNKFFFHQKDKGSVQAPEIS--SNSIKDSLVINERKDFSKNFEKNDIK 1379

  Fly  1332 ECGRTVGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSEN--------------- 1381
            |.|.......::.|             |:.:..|.:..:.||.|:...::
  Rat  1380 ERGPPKKRRQELES-------------DSESDGELQARKKVRVEIEQGQSSVPQHSELVGPSCAM 1431

  Fly  1382 EDEADSLMWPDFRYVTQ--C---IIQQNSVQIDRR-------VSQMRICSCLDSCSSDRCQCNGA 1434
            :|..|...|.:|..:.:  |   :|::|....:|:       :.:|: |.|......:|.|...|
  Rat  1432 DDFRDPQRWKEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQ-CECTPLSKDERAQGEVA 1495

  Fly  1435 SSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGV 1499
                  ..|..||.       .::.||:..|. |...|.||..|......::::..|  .||||:
  Rat  1496 ------CGEDCLNR-------LLMIECSSRCP-NGDYCSNRRFQRKQHADVEVILTE--KKGWGL 1544

  Fly  1500 RALANVPKGTFVGSYTGEILTAMEADRRTDD-------SYYF-DLDNGHCIDANYYGNVTRFFNH 1556
            ||..::|..|||..|.||:|...|...|..:       .||| .|.|...|||...||.:||.||
  Rat  1545 RAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNH 1609

  Fly  1557 SCEPNVLPVRVFYEHQDYRFP---KIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTT 1618
            |||||.       |.|.:...   ::.||:.:.:.:|.|:.|||..:.:..|.:.|.   |.:..
  Rat  1610 SCEPNC-------ETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCF---CGSAN 1664

  Fly  1619 CK 1620
            |:
  Rat  1665 CR 1666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	25/105 (24%)
		Ank_2	1056..1152	CDD:289560	23/149 (15%)
		ANK	1088..1217	CDD:238125	33/185 (18%)
		ANK repeat	1088..1120	CDD:293786	7/31 (23%)
		ANK repeat	1124..1153	CDD:293786	6/49 (12%)
		Ank_2	1127..1249	CDD:289560	28/170 (16%)
		ANK	1155..1306	CDD:238125	35/221 (16%)
		ANK repeat	1155..1196	CDD:293786	11/61 (18%)
		ANK repeat	1199..1249	CDD:293786	10/56 (18%)
		Ank_2	1205..1316	CDD:289560	25/161 (16%)
		ANK repeat	1251..1283	CDD:293786	6/45 (13%)
		ANK repeat	1285..1316	CDD:293786	8/60 (13%)
		PreSET	1357..1466	CDD:128744	24/135 (18%)
		SET	1495..1602	CDD:214614	44/117 (38%)
Setd2	XP_038937536.1	AWS	1475..1529	CDD:197795	17/68 (25%)
		SET_SETD2	1529..1670	CDD:380949	49/150 (33%)
		WW	2370..2399	CDD:395320
		SRI	2446..2534	CDD:400510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840