Protein Alignment G9a and Ezh2

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_006236463.1
• Gene: Ezh2 / 312299
• RGDID: 1595860
• Length: 751
• Species: Rattus norvegicus
• Alignment Length: 212
• Identity: 68/212 - (32%)
• Similarity: 94/212 - (44%)
• Gaps: 34/212 - (16%)

  Fly  1399 CIIQQNSVQIDRRVS---QMRI--CSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVI 1458
            |:|.||..:...:.|   |.|.  |.|...|::.:|.|        |.|....       ||.:.
  Rat   541 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC--------YLAVREC-------DPDLC 590

  Fly  1459 FECN--DVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTA 1521
            ..|.  |......:||||..:|.|::..|.:...:  ..|||:.....|.|..|:..|.|||::.
  Rat   591 LTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSD--VAGWGIFIKDPVQKNEFISEYCGEIISQ 653

  Fly  1522 MEADRRTD------DSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIA 1580
            .|||||..      .|:.|:|:|...:||...||..||.|||..||.. .:|...:.|:|   |.
  Rat   654 DEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCY-AKVMMVNGDHR---IG 714

  Fly  1581 FFSCRDIDAGEEICFDY 1597
            .|:.|.|..|||:.|||
  Rat   715 IFAKRAIQTGEELFFDY 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412
		EHMT_ZBD	786..933	CDD:411018
		ANKYR	1063..1322	CDD:440430
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		SET_EHMT	1391..1622	CDD:380941	68/212 (32%)
Ezh2	XP_006236463.1	EZH2_WD-Binding	39..68	CDD:463308
		PRC2_HTH_1	158..249	CDD:436286
		preSET_CXC	564..595	CDD:408079	10/45 (22%)
		SET_EZH2	614..733	CDD:380995	45/124 (36%)