DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment G9a and Nsd1

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_006253682.1 Gene:Nsd1 / 306764 RGDID:1307748 Length:2689 Species:Rattus norvegicus


Alignment Length:1950 Identity:346/1950 - (17%)
Similarity:583/1950 - (29%) Gaps:719/1950 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NSMSSTFNSDCATSTAEGGTLL-----NLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEERKEA 68
            |.:|...||...:|.|.|..|.     |....:.:|....:|:....::...||..::       
  Rat   549 NELSRIANSLTGSSAAPGQFLFSSCGQNTAKTDFETPNCDSLSGLSESALISKHSGEK------- 606

  Fly    69 RNQEEIEDIKALLADVVDAAAVKL------EEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAK 127
                     |.|....|.::.|:|      :||:..::..|     |...::|..    |.|..:
  Rat   607 ---------KKLQPGQVCSSKVQLCYVGAGDEEKRSDSVSV-----CTTSDDGSS----DLDPTE 653

  Fly   128 QDSEMEKKQNGKATSITVKMESNERA-EKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPIL 191
            .:||..|    ....:|..::..|.| ..|..|   |...|:...:...|:|.........:.::
  Rat   654 HNSEFHK----SVLEVTDALDKTENALSMHKNE---TKYSRYPATNRVKEKQKSLITNSHTDHLM 711

  Fly   192 AATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGG 256
            .:|:.:|..     |..|.....|.|.:||...|...:..|............:.::| .::.||
  Rat   712 DSTKTVEPG-----TAEISQVNLSDLKISSPIPKPQPEFRNDGLTTKFNAPPGIRNEN-SLTKGG 770

  Fly   257 TRRSR------RTPR-----------PIDTPTSVTDEHVQVE-------------NKKFGKSE-- 289
            .....      |.|:           |....||.|.|.:.::             ..|.||.|  
  Rat   771 LANQTLLPLKCRQPKFRSIKCKHKESPTAAETSATSEDLSLKCCSSDTNGSPMTSISKSGKGEGL 835

  Fly   290 -------QYTDCSSHLERFTLDDNTAIVR---LQLK----------------SEPDKPSLTALSP 328
                   :.|..||.:|       ||:|:   .:||                |:..||.|.:.:.
  Rat   836 KLLNNMHEKTRDSSDIE-------TAVVKHVLSELKELSYRSLSEDVSDSGTSKSSKPLLFSSAS 893

  Fly   329 EENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLV-VV 392
            .:|..|           |.||.:..|..::|              :.:.|....:|:|.... |.
  Rat   894 SQNHIP-----------IEPDYKFSTLLMML--------------KDMHDSKTKEQRLMTAQNVA 933

  Fly   393 KTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVK----------TEALHPQPSAELSFAE 447
            .....:.||...|......:.:.||...|....|.:..:          ..||..:.|:.||...
  Rat   934 SYRTPDRGDCSSGSPVGTSKVLVLGGSTHNSEKPGDSTQDSVRLSPGGGDSALSGELSSSLSVLP 998

  Fly   448 VTSEILPLA--VLDEKTPPKKRGRKAKTPCVKLESETSCGLPFAN-------------------- 490
            .....||..  :.....|.:..||...:|.:::...|....|..|                    
  Rat   999 SDKRDLPACGKIRSNCIPRRNCGRAKLSPKLRVTISTQMAKPSVNPKALKTERKRKLSRLPAVTL 1063

  Fly   491 -----GNKKTNSSGGCELQLPKRSKRRIKPTPK--ILENDELRCEFETKH------IERMTQWES 542
                 |||::..|....|:...:...:.:|..:  :|.|:|...:.:.|.      :|:...:|:
  Rat  1064 AANGLGNKESGGSVNGPLKGGAQDPAKEEPLQQMDLLRNEETHFDSKVKQSDPDKILEKEPSFEN 1128

  Fly   543 AAAVDGDFETPTTGGN------------------------------GSNSSTSRQK--SDKSDGS 575
            .       :.|..|..                              |..:|..|:|  |:.:.|.
  Rat  1129 R-------KGPEVGSEINIENDEPHGVDQVVPKKRWQRLNQRRPKPGKRASRFREKENSEGAFGV 1186

  Fly   576 NFEGGPGHPAGTSAIKKR-----LFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIK-----A 630
            ...|.|........:::|     :...|..|..:...:.....:|..|......:.|::     .
  Rat  1187 LLPGDPVQKGRDDYLEQRAPPTSILEDSAADPNHVSHSESVGPRLNVCDKSSVSMGDLEKETGIP 1251

  Fly   631 SRINANRSPE-----ERKLNKKQQRKLAKQKEKHLKHLGLQKNHR--DEPSDNDSSNTDNEFFPT 688
            |.....:.||     |:|..:|..:.|.:..|::.:....:|..:  .|.....||..::|    
  Rat  1252 SLTPQTKIPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDE---- 1312

  Fly   689 TRVQVGKPSVTLRVRNSV-TKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPIS 752
                    |:..|.|:|. .|::...:.:.::..|.|    |.|           ||.....|:.
  Rat  1313 --------SLLARCRSSAQNKQVDENSLISTKEEPPV----LER-----------EAPFLEGPLV 1354

  Fly   753 TPDAEQLH------SLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYAR---------- 801
            ..|....|      :|...:..:|:|      ||:.....   .|.:.|..|..:          
  Rat  1355 QSDLGVAHAELPQLTLSVPVAPEVSP------RPTLESEE---LLVKTPGNYEGKRQRKPTKKLL 1410

  Fly   802 --NAPDSSY------------CCAIDHIDD----------------------------------- 817
              |..|..:            ||...|:::                                   
  Rat  1411 ESNDLDPGFMPKKGDLGLSRKCCESGHLENGVGDSRATPHLKEFGGGTTRIFDKPRKRKRQRHGT 1475

  Fly   818 --------QKIGCCNELSSEVHNLL-------RPSQRVSYMILCDEH------KKRLQ------- 854
                    :|.....|..|.....|       .|.:.:...|   ||      .||||       
  Rat  1476 ARVHYKRVKKEDSARETPSSAEGELMIHRTAASPKEILEEGI---EHDPGMSASKRLQGERGGGA 1537

  Fly   855 --SHNCCAGCGIFCTQGKFVLCKQQ--HFFHPDC-------AQRFI-------LSTSYE-KELGD 900
              ..|.|..|.   ..|:.:||:.|  ..||.:|       ..:||       :.|.:. |:.|:
  Rat  1538 ALKENVCQNCE---KLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE 1599

  Fly   901 EEDQGVKFSSPVLVLKC--PHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQF 963
            :            |.:|  |.||....|       :|        .|||                
  Rat  1600 D------------VKRCLLPLCGKFYHE-------EC--------VQKY---------------- 1621

  Fly   964 GTVENANTPGATARNKG---GLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQL 1025
                    |....:|||   .|...:|..|| :||:.:  |.:||                    
  Rat  1622 --------PPTVVQNKGFRCPLHICITCHAA-NPANVS--ASKGR-------------------- 1655

  Fly  1026 IPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADF----NVLTPIR---- 1082
                :|..|          |....:...|...|..       ::|||::.    |..||.|    
  Rat  1656 ----LMRCV----------RCPVAYHANDFCLAAG-------SKILASNSIICPNHFTPRRGCRN 1699

  Fly  1083 -EYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFL--- 1143
             |::|.:...:.:..|:     ||.|.  |.|                |..:.:|  ||:.:   
  Rat  1700 HEHVNVSWCFVCSEGGS-----LLCCD--SCP----------------AAFHREC--LNIDIPEG 1739

  Fly  1144 --QCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWA 1206
              .|....|.|.|..:            |...:.|..||                   |    |.
  Rat  1740 NWYCNDCKAGKKPHYR------------EIVWVKVGRYR-------------------W----WP 1769

  Fly  1207 AELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITV 1271
            ||:.|         |:||                    |:..|...:.|                
  Rat  1770 AEICH---------PRAV--------------------PSNIDKMRHDV---------------- 1789

  Fly  1272 LLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPF-DCIPNEESECGR 1335
                          |:.|:              |.....|.:..::|...|: :...:.:.:.|:
  Rat  1790 --------------GEFPV--------------LFFGSNDYLWTHQARVFPYMEGDVSSKDKMGK 1826

  Fly  1336 TVGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCI 1400
            .|. ....::.:....|...:.|.    :|.|.:|           ||..:....|.:::     
  Rat  1827 GVD-GTYKKALQEAAARFEELKAQ----KELRQLQ-----------EDRKNDKKPPPYKH----- 1870

  Fly  1401 IQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DV 1464
                 ::::|.:.:::|.:. |.....||.|..       |.|:....|....:..:::||: .|
  Rat  1871 -----IKVNRPIGRVQIFTA-DLSEIPRCNCKA-------TDENPCGIDSECINRMLLYECHPTV 1922

  Fly  1465 CGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-- 1527
            |.... .|:|:.........::|.  ....:|||:|...::.||.||..|.||::...|...|  
  Rat  1923 CPAGG-RCQNQCFSKRQYPDVEIF--RTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIR 1984

  Fly  1528 ------TDDSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRF---PKIAFFS 1583
                  ..:.|...||....|||...||..||.||.|:||.       |.|.:..   .::..|:
  Rat  1985 YAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNC-------ETQKWSVNGDTRVGLFA 2042

  Fly  1584 CRDIDAGEEICFDYGEKFWRVEHRSCVG-----CRCLTTTCKYASQSSSTNASPTNATTAPENET 1643
            ..||.||.|:.|:|        :..|:|     |:|....|     |......|.|.....|.::
  Rat  2043 LSDIKAGTELTFNY--------NLECLGNGKTVCKCGAPNC-----SGFLGVRPKNQPIVTEEKS 2094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 18/98 (18%)
Ank_2 1056..1152 CDD:289560 22/109 (20%)
ANK 1088..1217 CDD:238125 23/133 (17%)
ANK repeat 1088..1120 CDD:293786 6/31 (19%)
ANK repeat 1124..1153 CDD:293786 6/33 (18%)
Ank_2 1127..1249 CDD:289560 21/126 (17%)
ANK 1155..1306 CDD:238125 17/150 (11%)
ANK repeat 1155..1196 CDD:293786 4/40 (10%)
ANK repeat 1199..1249 CDD:293786 9/49 (18%)
Ank_2 1205..1316 CDD:289560 14/110 (13%)
ANK repeat 1251..1283 CDD:293786 1/31 (3%)
ANK repeat 1285..1316 CDD:293786 4/30 (13%)
PreSET 1357..1466 CDD:128744 19/109 (17%)
SET 1495..1602 CDD:214614 38/117 (32%)
Nsd1XP_006253682.1 MSH6_like 319..429 CDD:99898
PHD1_NSD1_2 1543..1585 CDD:277118 11/44 (25%)
PHD2_NSD1 1590..1636 CDD:277120 17/96 (18%)
PHD3_NSD1 1637..1690 CDD:277123 16/96 (17%)
PHD4_NSD1 1707..1746 CDD:277126 11/63 (17%)
WHSC1_related 1752..1846 CDD:99899 25/202 (12%)
AWS 1889..1939 CDD:197795 12/57 (21%)
SET 1940..2063 CDD:214614 40/139 (29%)
PHD5_NSD1 2118..2160 CDD:277129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351961
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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