DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment G9a and Ezh1

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_001100521.1 Gene:Ezh1 / 303547 RGDID:1305028 Length:747 Species:Rattus norvegicus


Alignment Length:740 Identity:139/740 - (18%)
Similarity:226/740 - (30%) Gaps:282/740 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   967 ENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVM 1031
            |....||:..     :|.||.|....:....::..:.|...||:.....:...:...:       
  Rat   161 EEEMIPGSVL-----ISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTR------- 213

  Fly  1032 NVVLRGHVVSASGRVTAEFTPRDMYYA----------VQNDDLERVAEIL-AADFNVLTP-IREY 1084
              ..:.|.:..:.:.:.:..|.||.::          |.:|..||..|:. .:|.|.|.| ....
  Rat   214 --KRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPN 276

  Fly  1085 LNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQ----- 1144
            ::|.....|....:|...:.|.|:                          :|...:.||.     
  Rat   277 IDGPNAKSVQREQSLHSFHTLFCR--------------------------RCFKYDCFLHPFHAT 315

  Fly  1145 -----------------CGAD--VAIKGPDGKTSLH----------------IAAQLGNLEATQL 1174
                             ||||  :.::|......||                ::|...|..|:.:
  Rat   316 PNVYKRKNREIKIEPEPCGADCFLWLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNTSASAM 380

  Fly  1175 IVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLL 1239
                               |:.:.|                                        
  Rat   381 -------------------AETKEG---------------------------------------- 386

  Fly  1240 NQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIA 1304
                     |:|.:|...|::..::.                 |....||.......:..::|:.
  Rat   387 ---------DSDRDTGNDWASSSSEA-----------------NSRCQTPTKQKASPAPPQLCVV 425

  Fly  1305 LIANGADLMIKNKAEQLPFDCIPNEES--ECGRTVGFNMQMRSFRPLGLRT------FVVCADAS 1361
                        :|...|.:....|||  .......||......|.||.:|      |.|     
  Rat   426 ------------EAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAV----- 473

  Fly  1362 NGREARPIQVVRNELAMSENEDEADSLMW--------------------------PD--FRYVTQ 1398
              :|:..:::..:||.....:.:....:|                          ||  ......
  Rat   474 --KESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPCDSTCP 536

  Fly  1399 CIIQQNSVQIDRRVS---QMRI--CSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVI 1458
            ||:.||..:...:.|   |.|.  |.|...|::.:|.|        |.|               :
  Rat   537 CIMTQNFCEKFCQCSPDCQNRFPGCRCKTQCNTKQCPC--------YLA---------------V 578

  Fly  1459 FECN-DVC---------GCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGS 1513
            .||: |:|         .|..:||||..:|.|.:..|.:...:  ..|||.....:|.|..|:..
  Rat   579 RECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSD--VAGWGTFIKESVQKNEFISE 641

  Fly  1514 YTGEILTAMEADRRTD------DSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQ 1572
            |.||:::..|||||..      .|:.|:|:|...:||...||..||.|||..||.. .:|...:.
  Rat   642 YCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCY-AKVVMVNG 705

  Fly  1573 DYRFPKIAFFSCRDIDAGEEICFDY 1597
            |:|   |..|:.|.|.||||:.|||
  Rat   706 DHR---IGIFAKRAIQAGEELFFDY 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375
Ank_2 1056..1152 CDD:289560 21/131 (16%)
ANK 1088..1217 CDD:238125 19/168 (11%)
ANK repeat 1088..1120 CDD:293786 4/31 (13%)
ANK repeat 1124..1153 CDD:293786 7/52 (13%)
Ank_2 1127..1249 CDD:289560 15/161 (9%)
ANK 1155..1306 CDD:238125 15/166 (9%)
ANK repeat 1155..1196 CDD:293786 6/56 (11%)
ANK repeat 1199..1249 CDD:293786 1/49 (2%)
Ank_2 1205..1316 CDD:289560 8/110 (7%)
ANK repeat 1251..1283 CDD:293786 3/31 (10%)
ANK repeat 1285..1316 CDD:293786 3/30 (10%)
PreSET 1357..1466 CDD:128744 24/151 (16%)
SET 1495..1602 CDD:214614 43/109 (39%)
Ezh1NP_001100521.1 EZH2_WD-Binding 39..68 CDD:402972
PRC2_HTH_1 159..262 CDD:407952 19/114 (17%)
SANT 433..474 CDD:238096 11/47 (23%)
SET <463..727 CDD:225491 76/299 (25%)
SET_EZH1 608..743 CDD:380994 46/126 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352030
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.