DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and SETD2

DIOPT Version :10

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_054878.5 Gene:SETD2 / 29072 HGNCID:18420 Length:2564 Species:Homo sapiens


Alignment Length:1951 Identity:374/1951 - (19%)
Similarity:619/1951 - (31%) Gaps:665/1951 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 EKKHKDKEEEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEP---HTKCEIEEEG 115
            :.:|...||||     |:.:||:::       ....:|....:...:.:..|   .||..:||:|
Human    17 DPEHPTPEEEE-----NEAKIENVQ-------KTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQG 69

  Fly   116 RKEMEYDQDVAKQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKT----E 176
            |:::.:...:.|     :..||...|::..:.:| :.....|..:...||.:.:.|...|    |
Human    70 RQKVSFSFSLTK-----KTLQNRFLTALGNEKQS-DTPNPPAVPLQVDSTPKMKMEIGDTLSTAE 128

  Fly   177 QQNKKAAEKEEEPILAATQKLEANAEPL--TTTRIEVAVASPLVVSSASVKLAADATNQMRAATS 239
            :.:...:..|...|......|...:.||  |||    |||||...::....:.|::|......:|
Human   129 ESSPPKSRVELGKIHFKKHLLHVTSRPLLATTT----AVASPPTHAAPLPAVIAESTTVDSPPSS 189

  Fly   240 -------AGAATLADKNVQVSPGGTRRSRRT-------PRPIDTP-------------------- 270
                   |.|.||:.......|.....:..|       |.|:|..                    
Human   190 PPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADT 254

  Fly   271 -------------TSVTDEHVQVENKK----FGKSEQYTDCS----SHLERFTLDDNTAIVRLQL 314
                         |.:.:|...:.:||    .||.|:..|.|    |..:..:...::....:.|
Human   255 KQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFL 319

  Fly   315 KSEPDKPSLTALSPE------------------ENSAPAPKRGRGRARKIRPD----------AE 351
            .||.|:.|:...|.:                  ::|||......|:..:.:.|          .|
Human   320 GSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLE 384

  Fly   352 VETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGD--------APLGDVK 408
            .:|..|...|.   .|::  |:|.......::...::|...::|:....|        :|..:..
Human   385 RDTRYVSSRCR---SERE--RRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERT 444

  Fly   409 RMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPP-----KKRG 468
            |..|.. ..||........||.|........|...|:.::.:.....:..|.||..     ::||
Human   445 RYSRPY-TDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRG 508

  Fly   469 RKAKTPCVKLESETS-----------CGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILEN 522
            :.:.    |||.|:.           |..|...|.::.:|....:....:......||.||   :
Human   509 KYSS----KLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPK---S 566

  Fly   523 DELRCEF-ETKHIERMTQWESAAAVDGDFETPTTGGNG---SNSSTSRQKSDKSDGSNFEGGPGH 583
            |:.:..| .|:..|.:.|..|.:     .:||.:.|:.   .|.:..|:|               
Human   567 DKFKNSFCCTELNEEIKQSHSFS-----LQTPCSKGSELRMINKNPEREK--------------- 611

  Fly   584 PAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNK-- 646
             ||:.|...||                                         |.||..:||::  
Human   612 -AGSPAPSNRL-----------------------------------------NDSPTLKKLDELP 634

  Fly   647 ---------------KQQRKLAKQKEKHLKHL-GLQKNHRDEP---SD---------------ND 677
                           |:...|:|.|...|:.. .::.|....|   ||               :|
Human   635 IFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSD 699

  Fly   678 SSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATL-KSRRNPVVQAAKLTRRIGARAAGEV 741
            .|.|.:|..|..:..:...:....:.....|:|..|..| |...:|.                  
Human   700 DSVTGSELSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPF------------------ 746

  Fly   742 TEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLD------MRPSTSRVSKFICLCQKPSQYYA 800
                |.:.|:.:|..::|.|:         |:..:|      ..|..:|||   |...|.|..| 
Human   747 ----RETEPLVSPHQDKLMSM---------PVMTVDYSKTVVKEPVDTRVS---CCKTKDSDIY- 794

  Fly   801 RNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRV---SYM--------ILCDEHKKRLQ 854
                     |.   ::|.....||   ||..|:.....::   |:|        ::||  .:.|.
Human   795 ---------CT---LNDSNPSLCN---SEAENIEPSVMKISSNSFMNVHLESKPVICD--SRNLT 842

  Fly   855 SHNCCAGCGIFCTQ-----GKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLV 914
            .|:..|     |.:     |........||   |...:.|.|:.....| .....|:|..| :.:
Human   843 DHSKFA-----CEEYKQSIGSTSSASVNHF---DDLYQPIGSSGIASSL-QSLPPGIKVDS-LTL 897

  Fly   915 LKCPHCGLDTPERTSTV---TMKCQSLPVFLRTQKYKIKPARLTTSSHLTQ----FGTVENANTP 972
            |||       .|.||.|   .:|.:....||   |:..|...:...|.|..    |.:.||    
Human   898 LKC-------GENTSPVLDAVLKSKKSSEFL---KHAGKETIVEVGSDLPDSGKGFASREN---- 948

  Fly   973 GATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRG 1037
                |...||| ...|..|....:.....:|||                     ||..::....|
Human   949 ----RRNNGLS-GKCLQEAQEEGNSILPERRGR---------------------PEISLDERGEG 987

  Fly  1038 HVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFN-----VLTPIREYLNGT--------- 1088
            ..|..|......|:..|:...:::.|  .|...|..|.:     :::.:.|..:|:         
Human   988 GHVHTSDDSEVVFSSCDLNLTMEDSD--GVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESD 1050

  Fly  1089 -----------------CLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDY------ELRTAL--- 1127
                             .:.:|..:.||.|.....|...||..:.:..|:      |.|..|   
Human  1051 SEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEE 1115

  Fly  1128 -MCAVMNEKCDMLN-LFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLS 1190
             ..::.::.|...: .||..|.:   |.|:...:.....|:.|    :|...|:..|..:.| .|
Human  1116 KFESIASKACPQTDKFFLHKGTE---KNPEISFTQSSRKQIDN----RLPELSHPQSDGVDS-TS 1172

  Fly  1191 FIDAQDEGGWTAMVWAAELGH---TDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDN 1252
            ..|.:.:          .|||   .:.|: |.:|.                 .|..:..|..:|.
Human  1173 HTDVKSD----------PLGHPNSEETVK-AKIPS-----------------RQQEELPIYSSDF 1209

  Fly  1253 NTVLH--W--STLHNDGLDTI-TVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADL 1312
            ..|.:  |  :|..|.....: ...|...:.|.:.:|:|   ||.:  ..:..:       |.|.
Human  1210 EDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDG---LHSS--EELRNL-------GWDF 1262

  Fly  1313 MIKNKAEQLPFDCIPNEESECGRTVGFNMQM--------------------RSFRPLGL-----R 1352
                 :::.|.......:|..|...|...|.                    ||.||.|.     |
Human  1263 -----SQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDR 1322

  Fly  1353 T--------------------------------FVVCADASNGREARP---IQVVRNELAMSENE 1382
            |                                |::......|....|   ...:::.||::|.:
Human  1323 TQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKK 1387

  Fly  1383 D-----------------------EADS----------------------------LMWP----- 1391
            |                       |:||                            |:.|     
Human  1388 DFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSALVGPSCVMD 1452

  Fly  1392 DFR---YVTQC-----------IIQQNSVQIDRR-------VSQMRICSCLDSCSSDRCQCNGAS 1435
            |||   ...:|           :|::|....:|:       :.:|: |.|......:|.|...| 
Human  1453 DFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQ-CECTPLSKDERAQGEIA- 1515

  Fly  1436 SQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVR 1500
                 ..|..||.       .::.||:..|. |...|.||..|......::::..|  .||||:|
Human  1516 -----CGEDCLNR-------LLMIECSSRCP-NGDYCSNRRFQRKQHADVEVILTE--KKGWGLR 1565

  Fly  1501 ALANVPKGTFVGSYTGEILTAMEADRRTDD-------SYYF-DLDNGHCIDANYYGNVTRFFNHS 1557
            |..::|..|||..|.||:|...|...|..:       .||| .|.|...|||...||.:||.|||
Human  1566 AAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHS 1630

  Fly  1558 CEPNVLPVRVFYEHQDYRFP---KIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTC 1619
            ||||.       |.|.:...   ::.||:.:.:.:|.|:.|||..:.:..|.:.|.   |.:..|
Human  1631 CEPNC-------ETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCF---CGSANC 1685

  Fly  1620 K 1620
            :
Human  1686 R 1686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 PTZ00121 <68..>188 CDD:173412 23/126 (18%)
EHMT_ZBD 786..933 CDD:411018 37/165 (22%)
ANKYR 1063..1322 CDD:440430 52/308 (17%)
ANK repeat 1088..1120 CDD:293786 7/57 (12%)
ANK repeat 1124..1153 CDD:293786 6/33 (18%)
ANK repeat 1155..1196 CDD:293786 8/40 (20%)
ANK repeat 1199..1249 CDD:293786 8/52 (15%)
ANK repeat 1251..1283 CDD:293786 7/36 (19%)
ANK repeat 1285..1316 CDD:293786 5/30 (17%)
SET_EHMT 1391..1622 CDD:380941 74/267 (28%)
SETD2NP_054878.5 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..211 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..561 53/298 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..626 9/75 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..995 8/51 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1036..1101 10/64 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1133..1233 25/135 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1352 12/87 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1393..1443 3/49 (6%)
Interaction with TUBA1A. /evidence=ECO:0000269|PubMed:27518565 1418..1714 75/296 (25%)
AWS 1495..1549 CDD:197795 17/68 (25%)
SET_SETD2 1549..1690 CDD:380949 49/150 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1831..1872
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..2142
Low charge region. /evidence=ECO:0000269|PubMed:16118227 2137..2366
WW 2391..2420 CDD:459800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2439..2465
Interaction with POLR2A. /evidence=ECO:0000269|PubMed:16314571 2457..2564
SRI 2467..2555 CDD:462404
Blue background indicates that the domain is not in the aligned region.

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