DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment G9a and SETD2

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_011531934.1 Gene:SETD2 / 29072 HGNCID:18420 Length:2572 Species:Homo sapiens


Alignment Length:1944 Identity:372/1944 - (19%)
Similarity:615/1944 - (31%) Gaps:662/1944 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 DKEEEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQ 123
            ::|||...:..|.::...||..:...|.::....:..:          ||..:||:||:::.:..
Human    31 NREEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTK----------TKVNLEEQGRQKVSFSF 85

  Fly   124 DVAKQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKT----EQQNKKAAE 184
            .:.|     :..||...|::..:.:| :.....|..:...||.:.:.|...|    |:.:...:.
Human    86 SLTK-----KTLQNRFLTALGNEKQS-DTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSR 144

  Fly   185 KEEEPILAATQKLEANAEPL--TTTRIEVAVASPLVVSSASVKLAADATNQMRAATS-------A 240
            .|...|......|...:.||  |||    |||||...::....:.|::|......:|       |
Human   145 VELGKIHFKKHLLHVTSRPLLATTT----AVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPA 205

  Fly   241 GAATLADKNVQVSPGGTRRSRRT-------PRPIDTP---------------------------- 270
            .|.||:.......|.....:..|       |.|:|..                            
Human   206 QATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNS 270

  Fly   271 -----TSVTDEHVQVENKK----FGKSEQYTDCS----SHLERFTLDDNTAIVRLQLKSEPDKPS 322
                 |.:.:|...:.:||    .||.|:..|.|    |..:..:...::....:.|.||.|:.|
Human   271 LEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDS 335

  Fly   323 LTALSPE------------------ENSAPAPKRGRGRARKIRPD----------AEVETSEVIL 359
            :...|.:                  ::|||......|:..:.:.|          .|.:|..|..
Human   336 VRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSS 400

  Fly   360 PCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGD--------APLGDVKRMRRSVRL 416
            .|.   .|::  |:|.......::...::|...::|:....|        :|..:..|..|.. .
Human   401 RCR---SERE--RRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPY-T 459

  Fly   417 GNRLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPP-----KKRGRKAKTPCV 476
            .||........||.|........|...|:.::.:.....:..|.||..     ::||:.:.    
Human   460 DNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSS---- 520

  Fly   477 KLESETS-----------CGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEF- 529
            |||.|:.           |..|...|.::.:|....:....:......||.||   :|:.:..| 
Human   521 KLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPK---SDKFKNSFC 582

  Fly   530 ETKHIERMTQWESAAAVDGDFETPTTGGNG---SNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIK 591
            .|:..|.:.|..|.:     .:||.:.|:.   .|.:..|:|                ||:.|..
Human   583 CTELNEEIKQSHSFS-----LQTPCSKGSELRMINKNPEREK----------------AGSPAPS 626

  Fly   592 KRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNK---------- 646
            .||                                         |.||..:||::          
Human   627 NRL-----------------------------------------NDSPTLKKLDELPIFKSEFIT 650

  Fly   647 -------KQQRKLAKQKEKHLKHL-GLQKNHRDEP---SD---------------NDSSNTDNEF 685
                   |:...|:|.|...|:.. .::.|....|   ||               :|.|.|.:|.
Human   651 HDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSEL 715

  Fly   686 FPTTRVQVGKPSVTLRVRNSVTKELPTTATL-KSRRNPVVQAAKLTRRIGARAAGEVTEAARASV 749
            .|..:..:...:....:.....|:|..|..| |...:|.                      |.:.
Human   716 SPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPF----------------------RETE 758

  Fly   750 PISTPDAEQLHSLDTSIQADVTPIRDLD------MRPSTSRVSKFICLCQKPSQYYARNAPDSSY 808
            |:.:|..::|.|:         |:..:|      ..|..:|||   |...|.|..|         
Human   759 PLVSPHQDKLMSM---------PVMTVDYSKTVVKEPVDTRVS---CCKTKDSDIY--------- 802

  Fly   809 CCAIDHIDDQKIGCCNELSSEVHNLLRPSQRV---SYM--------ILCDEHKKRLQSHNCCAGC 862
             |.   ::|.....||   ||..|:.....::   |:|        ::||  .:.|..|:..|  
Human   803 -CT---LNDSNPSLCN---SEAENIEPSVMKISSNSFMNVHLESKPVICD--SRNLTDHSKFA-- 856

  Fly   863 GIFCTQ-----GKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGL 922
               |.:     |........||   |...:.|.|:.....| .....|:|..| :.:|||     
Human   857 ---CEEYKQSIGSTSSASVNHF---DDLYQPIGSSGIASSL-QSLPPGIKVDS-LTLLKC----- 908

  Fly   923 DTPERTSTV---TMKCQSLPVFLRTQKYKIKPARLTTSSHLTQ----FGTVENANTPGATARNKG 980
              .|.||.|   .:|.:....||   |:..|...:...|.|..    |.:.||        |...
Human   909 --GENTSPVLDAVLKSKKSSEFL---KHAGKETIVEVGSDLPDSGKGFASREN--------RRNN 960

  Fly   981 GLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGR 1045
            ||| ...|..|....:.....:|||                     ||..::....|..|..|..
Human   961 GLS-GKCLQEAQEEGNSILPERRGR---------------------PEISLDERGEGGHVHTSDD 1003

  Fly  1046 VTAEFTPRDMYYAVQNDDLERVAEILAADFN-----VLTPIREYLNGT----------------- 1088
            ....|:..|:...:::.|  .|...|..|.:     :::.:.|..:|:                 
Human  1004 SEVVFSSCDLNLTMEDSD--GVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDD 1066

  Fly  1089 ---------CLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDY------ELRTAL----MCAVMNE 1134
                     .:.:|..:.||.|.....|...||..:.:..|:      |.|..|    ..::.::
Human  1067 SSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASK 1131

  Fly  1135 KCDMLN-LFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEG 1198
            .|...: .||..|.:   |.|:...:.....|:.|    :|...|:..|..:.| .|..|.:.: 
Human  1132 ACPQTDKFFLHKGTE---KNPEISFTQSSRKQIDN----RLPELSHPQSDGVDS-TSHTDVKSD- 1187

  Fly  1199 GWTAMVWAAELGH---TDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLH--W 1258
                     .|||   .:.|: |.:|.                 .|..:..|..:|...|.:  |
Human  1188 ---------PLGHPNSEETVK-AKIPS-----------------RQQEELPIYSSDFEDVPNKSW 1225

  Fly  1259 --STLHNDGLDTI-TVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIAN-GADLMIKNKAE 1319
              :|..|.....: ...|...:.|.:.:|:|   ||.:          ..:.| |.|.     ::
Human  1226 QQTTFQNRPDSRLGKTELSFSSSCEIPHVDG---LHSS----------EELRNLGWDF-----SQ 1272

  Fly  1320 QLPFDCIPNEESECGRTVGFNMQM--------------------RSFRPLGL-----RT------ 1353
            :.|.......:|..|...|...|.                    ||.||.|.     ||      
Human  1273 EKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPD 1337

  Fly  1354 --------------------------FVVCADASNGREARP---IQVVRNELAMSENED------ 1383
                                      |::......|....|   ...:::.||::|.:|      
Human  1338 SLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLE 1402

  Fly  1384 -----------------EADS----------------------------LMWP-----DFR---Y 1395
                             |:||                            |:.|     |||   .
Human  1403 KNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQR 1467

  Fly  1396 VTQC-----------IIQQNSVQIDRR-------VSQMRICSCLDSCSSDRCQCNGASSQNWYTA 1442
            ..:|           :|::|....:|:       :.:|: |.|......:|.|...|      ..
Human  1468 WKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQ-CECTPLSKDERAQGEIA------CG 1525

  Fly  1443 ESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPK 1507
            |..||.       .::.||:..|. |...|.||..|......::::..|  .||||:||..::|.
Human  1526 EDCLNR-------LLMIECSSRCP-NGDYCSNRRFQRKQHADVEVILTE--KKGWGLRAAKDLPS 1580

  Fly  1508 GTFVGSYTGEILTAMEADRRTDD-------SYYF-DLDNGHCIDANYYGNVTRFFNHSCEPNVLP 1564
            .|||..|.||:|...|...|..:       .||| .|.|...|||...||.:||.|||||||.  
Human  1581 NTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNC-- 1643

  Fly  1565 VRVFYEHQDYRFP---KIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
                 |.|.:...   ::.||:.:.:.:|.|:.|||..:.:..|.:.|.   |.:..|:
Human  1644 -----ETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCF---CGSANCR 1694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 26/110 (24%)
Ank_2 1056..1152 CDD:289560 21/137 (15%)
ANK 1088..1217 CDD:238125 29/168 (17%)
ANK repeat 1088..1120 CDD:293786 7/57 (12%)
ANK repeat 1124..1153 CDD:293786 6/33 (18%)
Ank_2 1127..1249 CDD:289560 23/129 (18%)
ANK 1155..1306 CDD:238125 27/158 (17%)
ANK repeat 1155..1196 CDD:293786 8/40 (20%)
ANK repeat 1199..1249 CDD:293786 8/52 (15%)
Ank_2 1205..1316 CDD:289560 22/119 (18%)
ANK repeat 1251..1283 CDD:293786 7/36 (19%)
ANK repeat 1285..1316 CDD:293786 6/31 (19%)
PreSET 1357..1466 CDD:128744 29/188 (15%)
SET 1495..1602 CDD:214614 44/117 (38%)
SETD2XP_011531934.1 AWS 1503..1557 CDD:197795 17/68 (25%)
SET 1558..1681 CDD:214614 45/131 (34%)
PostSET 1682..1698 CDD:214703 4/16 (25%)
Asp-B-Hydro_N <1948..2131 CDD:191249
WW 2399..2428 CDD:278809
SRI 2477..2556 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158042
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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