Protein Alignment G9a and Setd2

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_036010808.1
• Gene: Setd2 / 235626
• MGIID: 1918177
• Length: 2551
• Species: Mus musculus
• Alignment Length: 1943
• Identity: 373/1943 - (19%)
• Similarity: 611/1943 - (31%)
• Gaps: 687/1943 - (35%)

  Fly    62 EEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEP---HTKCEIEEEGRKEMEYDQ 123
            |||.:....|.:||:::       ....:|....:...:.:..|   .||..:||:||:::.:..
Mouse    35 EEENETYHKQAKIENVQ-------KTGFIKGPVFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSF 92

  Fly   124 DVAKQDSE-------MEKKQNGKATSIT--VKMESNERAEKH------ATEIATTSTERWE--NE 171
            ...|:..:       ..:||:....|..  ::::||.:.:..      |||.::....|.|  ..
Mouse    93 SFTKKTLQNRFLTALSNEKQSDSPNSPAPPLQVDSNPKVKMDAGDTFPATEESSPPKSRVELGRI 157

  Fly   172 SFKTEQQNKKAAEKEEEPILAATQKLEANAEPL-TTTRIEVAVASPLVVSSASVKLAADATNQMR 235
            .||     |........|.|||:   ...|.|| .||::...:|..::.|..|.........|
Mouse   158 HFK-----KHLLHVTSRPQLAAS---TTAASPLPPTTQLPAVLAESMIDSPPSSPPPPPPPPQ-- 212

  Fly   236 AATSAGAATLADKNVQVSPGGTRRSRRTPRP-----------------------IDTPTSVT--- 274
            |::.:..|.:::......|..|......|.|                       :||...:.
Mouse   213 ASSPSPPAQISEPVALPQPPATALMTSPPGPLPGDVAVRAQKESPVKSGPEVLEVDTKQDIVSNS 277

  Fly   275 -DEH------------VQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQ--------LKSEP 318
             :||            :|.|:...||.|:.:|.|    :.:|....|..:.:        |.||.
Mouse   278 LEEHTVQTLKEQADHLLQKEDSHIGKEEEVSDGS----KISLSSKKASSKKKSSQFEGTFLGSES 338

  Fly   319 DKPSL--------------TALSPE----ENSAPAPKRGRGRARKIRPD----------AEVETS 355
            |:.|:              |::..|    ::|||:.....|::.:.:.:          .|.:|.
Mouse   339 DEDSVRTSSSQRSHDLKSSTSIDKERDFKKSSAPSKSEDLGKSSRSKTERDDRYCSYSKLERDTR 403

  Fly   356 EVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRL 420
            .|...|     ..:..|:|.......|:...:.|...::|:....|:.    :|..||
Mouse   404 YVSSRC-----RSERDRRRSRSRSRSDRASRTSLSYSRSERSHYYDSE----RRYHRS------- 452

  Fly   421 HADGSPWEEVKTEALHP---QPSAELSFAEVTSEILPLAVLDE--KTPPKKRG----RKAKTPCV 476
                ||:.| :|....|   ..:.|.|.:|           ||  ||.|::..    |..:|...
Mouse   453 ----SPYRE-RTRYSRPYTDNRARESSDSE-----------DEYKKTYPRRTSAHSYRDLRTSSS 501

  Fly   477 KLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEFET---------- 531
            ..:.:..|         ||.:|   .|::    :||.|.|.|:....:...|.||
Mouse   502 YSKFDRDC---------KTETS---YLEM----ERRGKYTSKLERESKRTSEHETIKRCCSPPNE 550

  Fly   532 ----------KHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGS------NFEGG 580
                      ||....::::||.                  |.|..|:||...|      |.|..
Mouse   551 LGFRRGSSYSKHDNSTSRYKSAL------------------SKSISKNDKFKNSFCCTELNEENK 597

  Fly   581 PGH------PAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSP 639
            ..|      |....:..:.:...|:|  |..|:         |.|..:  |||          ||
Mouse   598 QSHSFSLQTPCSKGSELRTINKISER--EKTGS---------PTPSNQ--LND----------SP 639

  Fly   640 EERKLNKKQQRK---LAKQKEKHLKHLGLQKNHRD--------EPSDNDSSNTDNEF--FPTTRV 691
            ..:||::....|   :.....:.:|.|.|.|...|        |.:.|.|..|:.:.  |.|::.
Mouse   640 TFKKLDESPVLKPEFIGHDGRESIKELELSKVKNDQLRNFCSIELNVNGSPETEADVATFCTSKT 704

  Fly   692 QVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTE------------- 743
            .    ::::...:|||         .|..:|:::|..|:.. |.:..|...|
Mouse   705 D----AISMTSDDSVT---------GSEVSPLIKACMLSSN-GFQNVGRCRERDSDDTCRQHNTS 755

  Fly   744 --AARASVPISTPDAEQLHSLDT-SIQADVTPIRD-LDMRPSTSRVSKFICLCQKPSQYYARNAP 804
              ..|...|:.:|..::|.||.. :|....|.|:: :|.|.|..:.......|.......|.||.
Mouse   756 KSPFREMEPLLSPHHDKLMSLPVKTIDYPKTLIKEPVDKRHSCCKTKDSDIYCSPNENPEAENAE 820

  Fly   805 D-----SSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRL-----QSHNCC 859
            .     ||:.....|::.:.:.|.|...::.|     |:..     |||:|:.:     .|||..
Mouse   821 PSAMTISSHSFVNVHLESKTVICDNREPTDRH-----SENT-----CDEYKQSIGSTSSASHNHF 875

  Fly   860 AG-----------------CGIFCTQ----------------------------------GKFVL 873
            .|                 .||.|.:                                  ||...
Mouse   876 DGLYEPIGSSGISSLQSPPSGIRCEENTSPTLDAVESKKGIDFLKYARKETDVGSALPDSGKGFS 940

  Fly   874 CKQQH------------------FFHP---------DCAQRFILSTS--------YEKELGDEED 903
            .:.:|                  ..|.         |..||.....|        |:..|..|:.
Mouse   941 WENRHNNVLSGQSLQEAQEEGNSILHERRGRPEIPLDEEQRGHTHISDDSEVVFPYDLNLTMEDS 1005

  Fly   904 QGVKFSSPVLVLKCPHCGLDTPERTSTV------------------------------------- 931
            .|:.::     |||...| :.||..|||
Mouse  1006 DGITYT-----LKCDSSG-NAPEIVSTVHEDYSGSSASSSDESDSEDTESDDSSIPRNRLQSVVV 1064

  Fly   932 -----------TMKCQSLPVFLRTQKYKIKPAR----LTTSSHLTQFGTVENANTPGATARNKGG 981
                       |..|.|    ..:|.||....|    |.|..|..:    |...:.|.:...|..
Mouse  1065 VPKNSTLPMEETSPCSS----RSSQSYKHYSDRWEDGLETRRHAYE----EEYESKGCSQTEKYF 1121

  Fly   982 LSTAVTLSAASSPASKTNGAQR-----------GRAGTSNSNSRHALNSINFAQLIPESVMNVVL 1035
            |......||.|..:.....|..           |...||.::||    |.:...|.||..:...
Mouse  1122 LHKGTERSAESCYSQFGRKADNHLPDIAHAQSDGVDSTSQTDSR----SDHLGHLNPEDTLRAK- 1181

  Fly  1036 RGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQ 1100
                           |.|.....|.:||.|.                          :.:....|
Mouse  1182 ---------------TSRPQELPVYSDDFED--------------------------LPNKSRQQ 1205

  Fly  1101 MAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQ 1165
            |.:      ::.||...:...||.       .:..||:..:             ||   ||.:.:
Mouse  1206 MIF------SNRPDSSRLGKTELS-------FSSSCDISRM-------------DG---LHSSEE 1241

  Fly  1166 LGNLEATQLIVDSYRTSRNITSFL------------SFIDAQDEGGWTAMVWAAELGHTDIVRLA 1218
            |.||.     .|..:..|..|::.            .:..:.:..|.|...|... |:.| .|.|
Mouse  1242 LRNLG-----WDFSQQERPTTTYQQPDSSYGTCGTHKYQQSTEHYGGTHNYWQGN-GYWD-PRSA 1299

  Fly  1219 SLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNV-- 1281
            ..|....|....|         |...|:...:|.....||..             :||:..:.
Mouse  1300 GRPPGTGLAYDRI---------QGQVPDSLTDDREEEEHWDQ-------------RSGSHFSSPS 1342

  Fly  1282 ------QNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFN 1340
                  |..:|.........:|:           .|.::.|:.:....:...|:..|.|......
Mouse  1343 NKFFFHQKDKGSVQAPEISSNSI-----------KDALVMNERKDFSKNFEKNDIKERGPPKKRR 1396

  Fly  1341 MQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSEN---------------EDEADSLMW 1390
            .::.|             |:.:..|.:..:.||.|:...|:               :|..|...|
Mouse  1397 QELES-------------DSESDGELQARKKVRVEMEQGESSVPQHSELMGPSCAMDDFRDPQRW 1448

  Fly  1391 PDFRYVTQ--C---IIQQNSVQIDRR-------VSQMRICSCLDSCSSDRCQCNGASSQNWYTAE 1443
            .:|..:.:  |   :|::|....:|:       :.:|: |.|......:|.|...|      ..|
Mouse  1449 KEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQ-CECTPLSKDERAQGEVA------CGE 1506

  Fly  1444 SRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKG 1508
            ..||.       .::.||:..|. |...|.||..|......::::..|  .||||:||..::|..
Mouse  1507 DCLNR-------LLMIECSSRCP-NGDYCSNRRFQRKQHADVEVILTE--KKGWGLRAAKDLPSN 1561

  Fly  1509 TFVGSYTGEILTAMEADRRTDD-------SYYF-DLDNGHCIDANYYGNVTRFFNHSCEPNVLPV 1565
            |||..|.||:|...|...|..:       .||| .|.|...|||...||.:||.|||||||.
Mouse  1562 TFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNC--- 1623

  Fly  1566 RVFYEHQDYRFP---KIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
                |.|.:...   ::.||:.:.:.:|.|:.|||..:.:..|.:.|.   |.:..|:
Mouse  1624 ----ETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCF---CGSANCR 1674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	25/139 (18%)
		EHMT_ZBD	786..933	CDD:411018	43/290 (15%)
		ANKYR	1063..1322	CDD:440430	42/278 (15%)
		ANK repeat	1088..1120	CDD:293786	4/31 (13%)
		ANK repeat	1124..1153	CDD:293786	2/28 (7%)
		ANK repeat	1155..1196	CDD:293786	10/52 (19%)
		ANK repeat	1199..1249	CDD:293786	12/49 (24%)
		ANK repeat	1251..1283	CDD:293786	5/39 (13%)
		ANK repeat	1285..1316	CDD:293786	3/30 (10%)
		SET_EHMT	1391..1622	CDD:380941	71/253 (28%)
Setd2	XP_036010808.1	AWS	1483..1537	CDD:197795	17/68 (25%)
		SET_SETD2	1537..1678	CDD:380949	49/150 (33%)
		WW	2378..2407	CDD:459800
		SRI	2454..2542	CDD:462404