DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment G9a and Nsd3

DIOPT Version :10

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_001074738.1 Gene:Nsd3 / 234135 MGIID:2142581 Length:1446 Species:Mus musculus


Alignment Length:1668 Identity:322/1668 - (19%)
Similarity:520/1668 - (31%) Gaps:619/1668 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 KEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDS 130
            |..:|..|:.: .:|..|:::         |.|.:|    |||.  :.|.||             
Mouse   169 KTIQNGRELFE-SSLCGDLLN---------EVQASE----HTKS--KHESRK------------- 204

  Fly   131 EMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQ 195
            |..||.|        :.||:...|:.:.:|.....   |.::...|:.:....:..|||:|    
Mouse   205 EKRKKSN--------RHESSRSEERRSHKIPKLEP---EGQNRPNERVDTAPEKPREEPVL---- 254

  Fly   196 KLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQV---SPGGT 257
            |.....:|:.:       :.|...:|..||.........:..|......:...:.|:   |...|
Mouse   255 KEAIPVQPILS-------SVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKINT 312

  Fly   258 RRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPS 322
            |.:|             :.|||.             .|:..||..:.:..  || :.|.......
Mouse   313 RGAR-------------EYHVQF-------------FSNQPERAWVHEKR--VR-EYKGHEQYEE 348

  Fly   323 LTALSPEENSAPAPKRGRGRARKIRPDAEVETSEV-ILPCEDSLGEKKPGRKR--------KLPD 378
            |.|.:.::.|..:.|:   :.||.||..|....:: |...|.:|...:..|..        |.|:
Mouse   349 LLAEAAKQASNHSEKQ---KIRKPRPQRERAQWDIGIAHAEKALKMTREERVEQYTFIYIDKQPE 410

  Fly   379 EPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAEL 443
            |...|.:.:  |..|||           ||:.||.     |...:..|.:....|....|.|.:|
Mouse   411 EASSQAKKN--VTSKTE-----------VKKPRRP-----RSVLNSQPEQTNAGEVASSQSSTDL 457

  Fly   444 ---SFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSC---GLPFANGNKKTNSSGGCE 502
               |....||       |:|:.||.          ||:..:|:.   .||.:    .|...|..:
Mouse   458 RRQSQRRHTS-------LEEEEPPP----------VKIAWKTAAARKSLPAS----ITMHKGSLD 501

  Fly   503 LQLPKRSKRRIKPTPKI-----LENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNS 562
            ||     |..:.|..||     |:|    ...:.|.|::...  |...:....|....|.:....
Mouse   502 LQ-----KCNMSPVVKIEQVFALQN----ATGDGKFIDQFVY--STKGIGNKTEISVRGQDRLII 555

  Fly   563 STSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLND 627
            |:..|:|:|...|     ...|..||.....:..|.||                         ..
Mouse   556 SSPSQRSEKPAQS-----ASSPEATSGSAGPVEKKQQR-------------------------RS 590

  Fly   628 IKASRINANRSPE--ERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTR 690
            |: :|..:.:|.|  .:|..||:|.:.|.|..  || .||||. ..|.||:              
Mouse   591 IR-TRSESEKSAEVVPKKKIKKEQVETAPQAS--LK-TGLQKG-ASEISDS-------------- 636

  Fly   691 VQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRR------IGARAAGEVTEAARASV 749
               .||   |:.|              ||.:..|:.|..|.|      ....:.|:|....:...
Mouse   637 ---CKP---LKKR--------------SRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDS 681

  Fly   750 PISTPDAE--QLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPD-----SS 807
            |.:|.||:  ...|:|:|:..     |.:    .||:......:|:|        |.|     ..
Mouse   682 PSATADADASDAQSVDSSLSR-----RGV----GTSKKDTVCQVCEK--------AGDCLVACEG 729

  Fly   808 YCCAIDHIDDQKIGCCNELSS--EVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGK 870
            .||...|::      |..|::  |.|            ..|:|.:   ...:.|..|.:   .||
Mouse   730 ECCRHFHVE------CLGLTAVPEGH------------FTCEECE---TGQHPCFSCKV---SGK 770

  Fly   871 FV------LCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCP-HC------GL 922
            .|      :|.:  |:|..|.::|..:..        |.:|         .:|| ||      ..
Mouse   771 DVKRCSVSVCGK--FYHEACVRKFPTAIF--------ESKG---------FRCPQHCCSSCSMEK 816

  Fly   923 DTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKG---GLST 984
            |..:.:....|:|...||........:....::.|||:.........::..| |.|.|   ..:.
Mouse   817 DIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSA-AINVGFCFVCAR 880

  Fly   985 AVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQL-----IPESVMNVVLRGHVVSASG 1044
            .:.:...|.|...:...:          |.:.|:..|.|:|     ||.|           |||.
Mouse   881 GLIVQDHSDPMFSSYAYK----------SHYLLSESNRAELMKLPMIPSS-----------SASK 924

  Fly  1045 RVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKG 1109
            :                 ..|:...:|..:                               .|..
Mouse   925 K-----------------RCEKGGRLLCCE-------------------------------SCPA 941

  Fly  1110 ASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLH----IAAQLGNLE 1170
            :..|:.::|            .|.|.|...|   .|.|        || .||    :..:|||  
Mouse   942 SFHPECLSI------------DMPEGCWNCN---DCKA--------GK-KLHYKQIVWVKLGN-- 980

  Fly  1171 ATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFI 1235
                    ||                   |    |.||:         ..|::|.|         
Mouse   981 --------YR-------------------W----WPAEI---------CSPRSVPL--------- 996

  Fly  1236 SFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVE---GDTPLHIACRHS 1297
                                                        |:|.::   ||.|:.....| 
Mouse   997 --------------------------------------------NIQGLKHDLGDFPVFFFGSH- 1016

  Fly  1298 VTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASN 1362
                         |....::....|:  :..::.........|           :||....:.: 
Mouse  1017 -------------DYYWVHQGRVFPY--VEGDKHFAEGQTSIN-----------KTFKKALEEA- 1054

  Fly  1363 GREARPIQVVRNELAMSEN-EDEADSLMWPDFRYV-TQCIIQQNSVQIDRRVSQMRICSCL---- 1421
               |:..|.::.:....|. |.|..|...|.:::: ...:|.:..||: ..:|::..|:|.    
Mouse  1055 ---AKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQV-ADLSEIPRCNCKPGDE 1115

  Fly  1422 DSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPL 1485
            :.|..: .||....||                     :||: .||.... .|:|:..........
Mouse  1116 NPCGLE-SQCLNRMSQ---------------------YECHPQVCPAGD-RCQNQCFTKRLYPDA 1157

  Fly  1486 QIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEA--------DRRTDDSYYFDLDNGHCI 1542
            ::::.|  .:|||:|...::.||.||..|.||::...|.        :....:.|...:.....|
Mouse  1158 EVIKTE--RRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRII 1220

  Fly  1543 DANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRF---PKIAFFSCRDIDAGEEICFDYGEKFWRV 1604
            ||...||.:||.||||.||.       |.|.:..   .::..|:..||.||.|:.|:|       
Mouse  1221 DAGPKGNYSRFMNHSCNPNC-------ETQKWTVNGDVRVGLFALCDIPAGMELTFNY------- 1271

  Fly  1605 EHRSCVG-----CRCLTTTCKYASQSSSTNASPTNATTAPENE 1642
             :..|:|     |.|....|     |......|.:|.|:..:|
Mouse  1272 -NLDCLGNGRTVCHCGADNC-----SGFLGVRPKSACTSAVDE 1308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 PTZ00121 <68..>188 CDD:173412 23/119 (19%)
EHMT_ZBD 786..933 CDD:411018 30/166 (18%)
ANKYR 1063..1322 CDD:440430 34/265 (13%)
ANK repeat 1088..1120 CDD:293786 3/31 (10%)
ANK repeat 1124..1153 CDD:293786 6/28 (21%)
ANK repeat 1155..1196 CDD:293786 9/44 (20%)
ANK repeat 1199..1249 CDD:293786 7/49 (14%)
ANK repeat 1251..1283 CDD:293786 1/31 (3%)
ANK repeat 1285..1316 CDD:293786 5/33 (15%)
SET_EHMT 1391..1622 CDD:380941 60/252 (24%)
Nsd3NP_001074738.1 KIKL. /evidence=ECO:0000250|UniProtKB:Q9BZ95 164..167
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 191..257 23/99 (23%)
PWWP_NSD3_rpt1 278..407 CDD:438991 28/160 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..377 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..476 23/99 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..705 50/228 (22%)
PHD_SF 713..755 CDD:473978 12/67 (18%)
PHD2_NSD3 761..807 CDD:277122 14/67 (21%)
PHD_SF 808..860 CDD:473978 9/51 (18%)
PHD4_NSD3 927..962 CDD:277128 9/80 (11%)
PWWP_NSD3_rpt2 969..1063 CDD:438994 26/219 (12%)
AWS 1114..1152 CDD:465559 11/60 (18%)
SET_NSD3 1154..1295 CDD:380989 43/162 (27%)
PHD5_NSD3 1332..1374 CDD:277131
C5HCH 1373..1422 CDD:465605
Blue background indicates that the domain is not in the aligned region.

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