DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Nsd3

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001074738.1	Gene:	Nsd3 / 234135	MGIID:	2142581	Length:	1446	Species:	Mus musculus

Alignment Length:	1668	Identity:	322/1668 - (19%)
Similarity:	520/1668 - (31%)	Gaps:	619/1668 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDS 130
            |..:|..|:.: .:|..|:::         |.|.:|    |||.  :.|.||
Mouse   169 KTIQNGRELFE-SSLCGDLLN---------EVQASE----HTKS--KHESRK------------- 204

  Fly   131 EMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQ 195
            |..||.|        :.||:...|:.:.:|.....   |.::...|:.:....:..|||:|
Mouse   205 EKRKKSN--------RHESSRSEERRSHKIPKLEP---EGQNRPNERVDTAPEKPREEPVL---- 254

  Fly   196 KLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQV---SPGGT 257
            |.....:|:.:       :.|...:|..||.........:..|......:...:.|:   |...|
Mouse   255 KEAIPVQPILS-------SVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKINT 312

  Fly   258 RRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPS 322
            |.:|             :.|||.             .|:..||..:.:..  || :.|.......
Mouse   313 RGAR-------------EYHVQF-------------FSNQPERAWVHEKR--VR-EYKGHEQYEE 348

  Fly   323 LTALSPEENSAPAPKRGRGRARKIRPDAEVETSEV-ILPCEDSLGEKKPGRKR--------KLPD 378
            |.|.:.::.|..:.|:   :.||.||..|....:: |...|.:|...:..|..        |.|:
Mouse   349 LLAEAAKQASNHSEKQ---KIRKPRPQRERAQWDIGIAHAEKALKMTREERVEQYTFIYIDKQPE 410

  Fly   379 EPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAEL 443
            |...|.:.:  |..|||           ||:.||.     |...:..|.:....|....|.|.:|
Mouse   411 EASSQAKKN--VTSKTE-----------VKKPRRP-----RSVLNSQPEQTNAGEVASSQSSTDL 457

  Fly   444 ---SFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSC---GLPFANGNKKTNSSGGCE 502
               |....||       |:|:.||.          ||:..:|:.   .||.:    .|...|..:
Mouse   458 RRQSQRRHTS-------LEEEEPPP----------VKIAWKTAAARKSLPAS----ITMHKGSLD 501

  Fly   503 LQLPKRSKRRIKPTPKI-----LENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNS 562
            ||     |..:.|..||     |:|    ...:.|.|::...  |...:....|....|.:....
Mouse   502 LQ-----KCNMSPVVKIEQVFALQN----ATGDGKFIDQFVY--STKGIGNKTEISVRGQDRLII 555

  Fly   563 STSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLND 627
            |:..|:|:|...|     ...|..||.....:..|.||                         ..
Mouse   556 SSPSQRSEKPAQS-----ASSPEATSGSAGPVEKKQQR-------------------------RS 590

  Fly   628 IKASRINANRSPE--ERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTR 690
            |: :|..:.:|.|  .:|..||:|.:.|.|..  || .||||. ..|.||:
Mouse   591 IR-TRSESEKSAEVVPKKKIKKEQVETAPQAS--LK-TGLQKG-ASEISDS-------------- 636

  Fly   691 VQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRR------IGARAAGEVTEAARASV 749
               .||   |:.|              ||.:..|:.|..|.|      ....:.|:|....:...
Mouse   637 ---CKP---LKKR--------------SRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDS 681

  Fly   750 PISTPDAE--QLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPD-----SS 807
            |.:|.||:  ...|:|:|:..     |.:    .||:......:|:|        |.|     ..
Mouse   682 PSATADADASDAQSVDSSLSR-----RGV----GTSKKDTVCQVCEK--------AGDCLVACEG 729

  Fly   808 YCCAIDHIDDQKIGCCNELSS--EVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGK 870
            .||...|::      |..|::  |.|            ..|:|.:   ...:.|..|.:   .||
Mouse   730 ECCRHFHVE------CLGLTAVPEGH------------FTCEECE---TGQHPCFSCKV---SGK 770

  Fly   871 FV------LCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCP-HC------GL 922
            .|      :|.:  |:|..|.::|..:..        |.:|         .:|| ||      ..
Mouse   771 DVKRCSVSVCGK--FYHEACVRKFPTAIF--------ESKG---------FRCPQHCCSSCSMEK 816

  Fly   923 DTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKG---GLST 984
            |..:.:....|:|...||........:....::.|||:.........::..| |.|.|   ..:.
Mouse   817 DIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSA-AINVGFCFVCAR 880

  Fly   985 AVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQL-----IPESVMNVVLRGHVVSASG 1044
            .:.:...|.|...:...:          |.:.|:..|.|:|     ||.|           |||.
Mouse   881 GLIVQDHSDPMFSSYAYK----------SHYLLSESNRAELMKLPMIPSS-----------SASK 924

  Fly  1045 RVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKG 1109
            :                 ..|:...:|..:                               .|..
Mouse   925 K-----------------RCEKGGRLLCCE-------------------------------SCPA 941

  Fly  1110 ASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLH----IAAQLGNLE 1170
            :..|:.::|            .|.|.|...|   .|.|        || .||    :..:|||
Mouse   942 SFHPECLSI------------DMPEGCWNCN---DCKA--------GK-KLHYKQIVWVKLGN-- 980

  Fly  1171 ATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFI 1235
                    ||                   |    |.||:         ..|::|.|
Mouse   981 --------YR-------------------W----WPAEI---------CSPRSVPL--------- 996

  Fly  1236 SFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVE---GDTPLHIACRHS 1297
                                                        |:|.::   ||.|:.....|
Mouse   997 --------------------------------------------NIQGLKHDLGDFPVFFFGSH- 1016

  Fly  1298 VTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASN 1362
                         |....::....|:  :..::.........|           :||....:.:
Mouse  1017 -------------DYYWVHQGRVFPY--VEGDKHFAEGQTSIN-----------KTFKKALEEA- 1054

  Fly  1363 GREARPIQVVRNELAMSEN-EDEADSLMWPDFRYV-TQCIIQQNSVQIDRRVSQMRICSCL---- 1421
               |:..|.::.:....|. |.|..|...|.:::: ...:|.:..||: ..:|::..|:|.
Mouse  1055 ---AKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQV-ADLSEIPRCNCKPGDE 1115

  Fly  1422 DSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPL 1485
            :.|..: .||....||                     :||: .||.... .|:|:..........
Mouse  1116 NPCGLE-SQCLNRMSQ---------------------YECHPQVCPAGD-RCQNQCFTKRLYPDA 1157

  Fly  1486 QIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEA--------DRRTDDSYYFDLDNGHCI 1542
            ::::.|  .:|||:|...::.||.||..|.||::...|.        :....:.|...:.....|
Mouse  1158 EVIKTE--RRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRII 1220

  Fly  1543 DANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRF---PKIAFFSCRDIDAGEEICFDYGEKFWRV 1604
            ||...||.:||.||||.||.       |.|.:..   .::..|:..||.||.|:.|:|
Mouse  1221 DAGPKGNYSRFMNHSCNPNC-------ETQKWTVNGDVRVGLFALCDIPAGMELTFNY------- 1271

  Fly  1605 EHRSCVG-----CRCLTTTCKYASQSSSTNASPTNATTAPENE 1642
             :..|:|     |.|....|     |......|.:|.|:..:|
Mouse  1272 -NLDCLGNGRTVCHCGADNC-----SGFLGVRPKSACTSAVDE 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	15/97 (15%)
		Ank_2	1056..1152	CDD:289560	11/95 (12%)
		ANK	1088..1217	CDD:238125	22/132 (17%)
		ANK repeat	1088..1120	CDD:293786	3/31 (10%)
		ANK repeat	1124..1153	CDD:293786	6/28 (21%)
		Ank_2	1127..1249	CDD:289560	22/125 (18%)
		ANK	1155..1306	CDD:238125	22/157 (14%)
		ANK repeat	1155..1196	CDD:293786	9/44 (20%)
		ANK repeat	1199..1249	CDD:293786	7/49 (14%)
		Ank_2	1205..1316	CDD:289560	13/113 (12%)
		ANK repeat	1251..1283	CDD:293786	1/31 (3%)
		ANK repeat	1285..1316	CDD:293786	5/33 (15%)
		PreSET	1357..1466	CDD:128744	21/115 (18%)
		SET	1495..1602	CDD:214614	36/117 (31%)
Nsd3	NP_001074738.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..257		23/99 (23%)
		MSH6_like	277..393	CDD:99898	28/147 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..377		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..476		23/99 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..705		50/228 (22%)
		PHD_SF	713..755	CDD:304600	12/67 (18%)
		PHD2_NSD3	761..807	CDD:277122	14/67 (21%)
		PHD_SF	808..860	CDD:304600	9/51 (18%)
		PHD4_NSD3	927..962	CDD:277128	9/80 (11%)
		WHSC1_related	968..1061	CDD:99899	27/218 (12%)
		AWS	1104..1154	CDD:197795	13/72 (18%)
		SET	1155..1278	CDD:214614	38/139 (27%)
		PHD5_NSD3	1332..1374	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840