DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Setd1a

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_821172.2	Gene:	Setd1a / 233904	MGIID:	2446244	Length:	1716	Species:	Mus musculus

Alignment Length:	1106	Identity:	211/1106 - (19%)
Similarity:	358/1106 - (32%)	Gaps:	398/1106 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELMNSMSSTFNSDCATSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEERKEARN 70
            |:.:.|....|.....:.|.|.........|:|...::|.|..|     .|.:|||:.:.||...
Mouse   816 EMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQ-----AKEEDKEKMKLKEPGM 875

  Fly    71 QEEIEDIKALLADVVDAAA---------------VKLEE----EEAQNAEKVEPHTKCEIEEEGR 116
            ...::..|:.....::|.|               ||.:|    .||...::..|.|..| |:|..
Mouse   876 LSLVDWAKSGGITGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAE-EDEDD 939

  Fly   117 KEMEYD--------QDVAKQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESF 173
            .|.|.:        ....|:|.|..|.|.....|.|:..|..|.:::       :|:|:.|::..
Mouse   940 PEREKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFTLDSEGEEASQE-------SSSEKDEDDDD 997

  Fly   174 KTEQQNKKAAEKEEEPILAATQKLEA--------------------NAEPLTTTRIEVAVASPLV 218
            :.|:.     |::||.:.|..::.||                    :.|..:|:..|
Mouse   998 EDEED-----EEQEEAVDATKKEAEASDGEDEDSDSSSQCSLYADSDGENGSTSDSE-------- 1049

  Fly   219 VSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENK 283
              |.|...::.:::...:::|:.:::..::...|.|     |...||.:..|....||..:.:.
Mouse  1050 --SGSSSSSSSSSSSSSSSSSSESSSEEEEQSAVIP-----SASPPREVPEPLPAPDEKPETDG- 1106

  Fly   284 KFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTALSP-------------------- 328
                               |.|:..:...:.::.|.:|:..|..|
Mouse  1107 -------------------LVDSPVMPLSEKETLPTQPAGPAEEPPPSVPQPPAEPPAGPPDAAP 1152

  Fly   329 ---EENSAPAP------KRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGR-KRKLP------ 377
               |..|:|.|      ||.:..:.....:|.|.......|    |..|..|. .||:|
Mouse  1153 RLDERPSSPIPLLPPPKKRRKTVSFSAAEEAPVPEPSTAAP----LQAKSSGPVSRKVPRVVERT 1213

  Fly   378 --DEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPS 440
              :.|:|...|     ||:..||        |.|..|: |.|.|:.   |..||..||
Mouse  1214 IRNLPLDHASL-----VKSWPEE--------VARGGRN-RAGGRVR---STEEEEATE------- 1254

  Fly   441 AELSFAEVTSEILPLAVL-DEKTPPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQ 504
               |..||     .|||| |....|.:||...              ||..:.::.|.:|...|..
Mouse  1255 ---SGTEV-----DLAVLADLALTPARRGLAT--------------LPTGDDSEATETSDEAERP 1297

  Fly   505 LPKRS--------------------KRRIKPTPK-------------------ILENDELRCEFE 530
            .|..|                    .|.::|.|.                   :.|.:|.:.:.:
Mouse  1298 SPLLSHILLEHNYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEPKQQLQ 1362

  Fly   531 TKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKR-L 594
            .:|.|:..:.|     :.|.|..:.....|:||:|.:          ||         ||::| |
Mouse  1363 QQHPEQEGEEE-----EEDEEEESESSESSSSSSSDE----------EG---------AIRRRSL 1403

  Fly   595 FSKSQRDIENYGAAMLAKSKLPPCP----------DVEQ--FLNDIKASRINANRSPEERKLNKK 647
            .|.::|          .:..|||.|          :.||  .|.||    .|:....|:....:.
Mouse  1404 RSHTRR----------RRPPLPPPPPPPPSFEPRSEFEQMTILYDI----WNSGLDLEDMSYLRL 1454

  Fly   648 QQRKLAKQ-------KEKH-----LKHLGLQKNHR---DEPSDNDSSNTDNE-FFPTTRVQVGK- 695
            ...:|.:|       .:.|     :.:|...|..|   |.|.::.:.:..:| ::|.::.:..|
Mouse  1455 TYERLLQQTSGADWLNDTHWVQHTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKY 1519

  Fly   696 ----PSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDA 756
                |....::....|:  .|...|..||:   :..:|...||..|             |...|.
Mouse  1520 LDVCPVSARQLEGGDTQ--GTNRVLSERRS---EQRRLLSAIGTSA-------------IMDSDL 1566

  Fly   757 EQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKP-----------------------SQY 798
            .:|:.|         ..|...:|...||:.::.....:|                       .:.
Mouse  1567 LKLNQL---------KFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKR 1622

  Fly   799 YARNAPDSSYCCAIDH---IDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCA 860
            |.:....|||...:||   ||..|   |..|:..:::...|                    ||.|
Mouse  1623 YVQEGIGSSYLFRVDHDTIIDATK---CGNLARFINHCCTP--------------------NCYA 1664

  Fly   861 GCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKE-LGDEEDQGVKFSSPVLVLKCP-HCGLD 923
            ......:|.|.|:                    |.|: :|.:|:....:..|:...|.| .||.:
Mouse  1665 KVITIESQKKIVI--------------------YSKQPIGVDEEITYDYKFPLEDNKIPCLCGTE 1709

  Fly   924 T 924
            :
Mouse  1710 S 1710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	17/117 (15%)
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744
		SET	1495..1602	CDD:214614
Setd1a	NP_821172.2	RRM_Set1A	92..186	CDD:240992
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..367
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..670
		Topoisomer_IB_N	<835..>883	CDD:322080	12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..869		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1206		63/346 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1259		14/50 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1297		6/35 (17%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:O15047	1307..1311		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1355..1427		22/105 (21%)
		Interaction with CFP1. /evidence=ECO:0000250\|UniProtKB:O15047	1424..1459		7/38 (18%)
		N-SET	1434..1571	CDD:314603	29/158 (18%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250\|UniProtKB:O15047	1459..1546		15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1508		6/27 (22%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:O15047	1501..1506		0/4 (0%)
		SET	1577..1700	CDD:214614	27/165 (16%)
		PostSET	1700..1716	CDD:214703	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930