DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment G9a and Kmt2c

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_006535745.1 Gene:Kmt2c / 231051 MGIID:2444959 Length:4976 Species:Mus musculus


Alignment Length:1912 Identity:364/1912 - (19%)
Similarity:598/1912 - (31%) Gaps:627/1912 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 TSTAEGGTLLNLNLAEDKTLKWRNLANNQFA----SKEKKHKDKEEEERKEARNQEEIEDIKALL 81
            |.|...||:.:.|.......:.....||.|:    .:|:|.:.:|::||:..:..:|::..:|| 
Mouse  3376 TCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERERKERLREQQERQRVQLMQEVDRQRAL- 3439

  Fly    82 ADVVDAAAVKLEEEEAQNAEKVE--PHTK---------CEIEEEGRKEMEYDQDVAKQDSEMEKK 135
                 ...:::|:.....||...  |.::         |:..:..|...:..|. .:|...:.::
Mouse  3440 -----QQRMEMEQHCLMGAELANRTPVSQMPFYGSDRPCDFLQPPRPLQQSPQH-QQQIGPVLQQ 3498

  Fly   136 QNGKATSIT-----VKMESNERAE----KHATEIATTSTERWENESFKTEQQNKKAAEKEEEPIL 191
            ||.:..|:.     ..|::||:.:    ....:..:.|.......|.|....|...:..::.|:.
Mouse  3499 QNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGGSPNFHSVKPGHGNLPGSSFQQSPLR 3563

  Fly   192 AATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGG 256
            .....:.....|:..:.:... ..|.|..           .|..:.:|.....|....:....|.
Mouse  3564 PPFTPILPGTSPVANSNVPCG-QDPAVTQ-----------GQNYSGSSQSLIQLYSDIIPEEKGK 3616

  Fly   257 TRRSRRTPRPIDTPTSVTDEHVQVENKKFGK--SEQYTDCSSHLERFTLDDNTAIVRLQLKSEPD 319
            .:|:|:..:..|..:              ||  |..::||::.|.. .|.:.|:...:...||  
Mouse  3617 KKRTRKKKKDDDAES--------------GKAPSTPHSDCAAPLTP-GLSETTSTPAVSSPSE-- 3664

  Fly   320 KPSLTALSPEENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQ 384
               |.....:|...|.|.          |...|...:   ||.:|        :.|||:....::
Mouse  3665 ---LPQQRQQEPVEPVPV----------PTPNVSAGQ---PCIES--------ENKLPNSEFIKE 3705

  Fly   385 QLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEVT 449
            ..:....|..|    .|.|         ||...|:.       ||:|.|....|||.|       
Mouse  3706 TSNQQTHVNAE----ADKP---------SVETPNKT-------EEIKLEKAETQPSQE------- 3743

  Fly   450 SEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSC-----GLPFANGNKKTNSSGGCEL--QLPK 507
                     |.|. .:|.|.|.|.......|...|     |.|...|:.      |.||  .|.|
Mouse  3744 ---------DTKV-EEKTGNKIKDIVAGPVSSIQCPSHPVGTPTTKGDT------GNELLKHLLK 3792

  Fly   508 RSKRRIKPTPK---ILENDELRCEFETKHIERMTQWES----AAAVDGDF-----ETPTTGGNGS 560
            ..|.....|.|   .|.:||...: :.|.||:.:..|.    .|.:.|.|     :.|.|.|...
Mouse  3793 NKKASSLLTQKPEGTLSSDESSTK-DGKLIEKQSPAEGLQTLGAQMQGGFGGGNSQLPKTDGASE 3856

  Fly   561 N-------------SSTSRQKSDKSD-------------------------------GSNFEGGP 581
            |             .:..|.|..|.|                               |.||    
Mouse  3857 NKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSSDSFTHLKQQLSLLPLMEPIIGVNF---- 3917

  Fly   582 GH--PAGTSAIKKRLFSKSQRDIENYGAAML----------------------AKSKLPPCPD-- 620
            .|  |.|:..     |:...|.:..:|:|.|                      ..:.|||.|.  
Mouse  3918 AHFLPYGSGQ-----FNSGTRLLGTFGSAALEGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPM 3977

  Fly   621 -VEQFLNDIKASRINANRS-------------PEERKLN-KKQQRKLAKQKEKHLKHLGL----- 665
             .::..|....:...|.::             |:..:|. :.|...||:...:..|.:.:     
Mouse  3978 ACQKMANGFATTEELAGKAGVLVSHEVARALGPKPFQLPFRPQDDLLARAIAQGPKTVDVPASLP 4042

  Fly   666 ---QKNH-----RDEPSDNDSSNTDNEFFPTTR------VQVGK-PSVTL-------RVRNSVTK 708
               ..||     :|...|.|   |.:.|.|::.      |:|.| |.::|       .|.:.:..
Mouse  4043 TPPHNNHEELRIQDHYGDRD---TPDSFVPSSSPESVVGVEVNKYPDLSLVKEEPPEPVPSPIIP 4104

  Fly   709 ELPTTA--TLKSRRNPV-VQAAKL--TRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQA 768
            .||:.:  ..:||||.: .:...|  |...|:...|..:.....::.:....||.:.|:..:. :
Mouse  4105 ILPSISGKNSESRRNDIKTEPGTLFFTSPFGSSPNGPRSGLISVAITLHPTAAENISSVVAAF-S 4168

  Fly   769 DVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNL 833
            |:..:|                   .|:.|...||||..   .:..:...::.  ..|....|.|
Mouse  4169 DLLHVR-------------------IPNSYEVSNAPDVP---PMGLVSSHRVN--PSLEYRQHLL 4209

  Fly   834 LR---------PSQRVSYMILCDEHKKRLQ-------------------SHNCCAGCGI---FCT 867
            ||         |....||         ||:                   ||....|..:   :|.
Mouse  4210 LRGPPPGSANPPRLATSY---------RLKQPNVPFPPTSNGLSGYKDSSHGPAEGASLRPQWCC 4265

  Fly   868 QGKFVL--------CKQQHFFHPD--------------CAQR-FILSTSYEKELGDEEDQGVKFS 909
            ..|.|:        ||...|.:..              |:.. |||.:|..:....:.    |.|
Mouse  4266 HCKVVILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYSSAAQAKNSDN----KES 4326

  Fly   910 SPVLVLKCPHCGLDTPERT--------STVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTV 966
            .|.|    |...:..|.:.        ||:.:.|  ||.|    :.|:.|......|....|...
Mouse  4327 LPSL----PQSPMKEPSKAFHQYSNNISTLDVHC--LPQF----QEKVSPPASPPISFPPAFEAA 4381

  Fly   967 ENANTPG---ATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPE 1028
            :..:.|.   .|.:.|..|.|.........|.:|     :.|.......|.|.        :||:
Mouse  4382 KVESKPDELKVTVKLKPRLRTVPVGLEDCRPLNK-----KWRGMKWKKWSIHI--------VIPK 4433

  Fly  1029 SVMNVVLRGHVVSASGRVTAEF------------TPRD----MYYAVQNDDL-ERVAEILAADFN 1076
            ..........:        .||            .|:|    .:...:.|.| :..|.:|..|.:
Mouse  4434 GTFKPPCEDEI--------DEFLKKLGTCLKPDPVPKDCRKCCFCHEEGDGLTDGPARLLNLDLD 4490

  Fly  1077 V---------LTPIREYLNGTCLHL-VAHSGTLQMAYLLLCK-GASSP----DFVNIVDYELRTA 1126
            :         .|.:.|...|..::: :|....|||..:...| ||:|.    ...||..:...|.
Mouse  4491 LWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCATK 4555

  Fly  1127 LMCAVMNEK---CDM----------LNLF------------LQCGADVAIKGPD------GKTSL 1160
            ..|....:|   |.|          |:.|            ::..|.:..:|..      |....
Mouse  4556 AQCMFFKDKTMLCPMHKPKGIHEQQLSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIF 4620

  Fly  1161 HIAAQL--GNLEA----TQLIVDSYRTSRNITS---------FLSFIDAQDEGGWTAMVWAAELG 1210
            |...||  ..::|    ..|....|..||...|         :|..|:.:| |....::...|.|
Mouse  4621 HTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKD-GRPVFVIRIVEQG 4684

  Fly  1211 HTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQS 1275
            |.|:|...|.|:.|:.|::              :|..|....:.:|.....:..|.|...:.:.:
Mouse  4685 HEDLVLSDSSPKDVWDKIL--------------EPVACVRKKSEMLQLFPAYLKGEDLFGLTVSA 4735

  Fly  1276 GADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFN 1340
                 |..:....|...||.:...|..            :|...:||.                 
Mouse  4736 -----VARIAESLPGVEACENYTFRYG------------RNPLMELPL----------------- 4766

  Fly  1341 MQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNS 1405
                :..|.|      ||              |:|..||              .:|.:.:::.::
Mouse  4767 ----AVNPTG------CA--------------RSEPKMS--------------AHVKRFVLRPHT 4793

  Fly  1406 VQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQL 1470
                           |:|.|:.:      |.|:..|.|  |||.::.:            ..:..
Mouse  4794 ---------------LNSTSTSK------SFQSTVTGE--LNAPYSKQ------------FVHSK 4823

  Fly  1471 SCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------T 1528
            |.:.|.::  |.....:.....:.:|.|:.|..::.|.|.|..|.|.|:....|:|:       .
Mouse  4824 SSQYRRMK--TEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQN 4886

  Fly  1529 DDSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEI 1593
            ...|.|.:||.|.|||...|...|:.||||.||.:...|.:|    |..||...|.|.|..|||:
Mouse  4887 RGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFE----RGHKIIISSNRRIQKGEEL 4947

  Fly  1594 CFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
            |:||...|...:|:  :.|.|....|:
Mouse  4948 CYDYKFDFEDDQHK--IPCHCGAVNCR 4972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 13/101 (13%)
Ank_2 1056..1152 CDD:289560 26/136 (19%)
ANK 1088..1217 CDD:238125 38/180 (21%)
ANK repeat 1088..1120 CDD:293786 10/37 (27%)
ANK repeat 1124..1153 CDD:293786 8/53 (15%)
Ank_2 1127..1249 CDD:289560 32/167 (19%)
ANK 1155..1306 CDD:238125 33/171 (19%)
ANK repeat 1155..1196 CDD:293786 12/61 (20%)
ANK repeat 1199..1249 CDD:293786 10/49 (20%)
Ank_2 1205..1316 CDD:289560 19/110 (17%)
ANK repeat 1251..1283 CDD:293786 4/31 (13%)
ANK repeat 1285..1316 CDD:293786 4/30 (13%)
PreSET 1357..1466 CDD:128744 17/108 (16%)
SET 1495..1602 CDD:214614 41/113 (36%)
Kmt2cXP_006535745.1 PHD2_KMT2C 390..435 CDD:277069
PHD3_KMT2C 466..517 CDD:276986
PHD4_KMT2C 947..1003 CDD:277071
PHD5_KMT2C_like 1004..1050 CDD:276988
RanBP2-type Zn finger 1079..1101 CDD:275375
PHD6_KMT2C 1081..1131 CDD:277073
HMG-box 1661..1712 CDD:381793
Tma16 1699..>1782 CDD:371407
PHA03247 <1880..2370 CDD:223021
PHA03247 <2146..2753 CDD:223021
PKK 3189..3275 CDD:372134
Atrophin-1 3288..>3590 CDD:367360 37/221 (17%)
ePHD2_KMT2C 4467..4571 CDD:277167 22/103 (21%)
FYRN 4616..4667 CDD:368685 11/50 (22%)
FYRC 4673..4757 CDD:368686 19/102 (19%)
SET_KMT2C_2D 4823..4975 CDD:380948 49/158 (31%)
ePHD1_KMT2C 247..330 CDD:277166
PHD1_KMT2C_like 343..388 CDD:276984
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848421
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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