Protein Alignment G9a and SETD1B

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: NP_001340274.1
• Gene: SETD1B / 23067
• HGNCID: 29187
• Length: 1966
• Species: Homo sapiens
• Alignment Length: 1650
• Identity: 280/1650 - (16%)
• Similarity: 461/1650 - (27%)
• Gaps: 681/1650 - (41%)

  Fly    53 KEKKHKDKEEEERK--------EARNQEEIEDIKAL-----LADVVDAAAVKLEEEE------AQ 98
            |..:|||::..:.|        |:..:.|....:.|     |...:...:.|::.:|      :.
Human   912 KSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSG 976

  Fly    99 NAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDSEMEKKQNGKATSI------TVKMESNERAEKHA 157
            :.:::.|.|..: ||:...|.|.|:|:|....|:.|: :.|...:      .::::|....::..
Human   977 DQKRLRPSTSVD-EEDEESERERDRDMADTPCELAKR-DPKGVGVRRRPARPLELDSGGEEDEKE 1039

  Fly   158 TEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSA 222
            :..|::|:....:....|...:..|::||||.  .:|:: |..||......:..:..|....||.
Human  1040 SLSASSSSSASSSSGSSTTSPSSSASDKEEEQ--ESTEE-EEEAEEEEEEEVPRSQLSSSSTSST 1101

  Fly   223 SVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGK 287
            |.|...|..:..|..:.......|.........|......|...:.:....|......|:.:|..
Human  1102 SDKDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFES 1166

  Fly   288 SEQYTDCSSHLERFTLDDNTAIVRLQLKSEPD-----KPSLTALSPE------ENSAPAPKRGRG 341
            |.:.:..||.      |:...:.|.:.:.|.:     :.|:.:..||      |.:|.||.....
Human  1167 SSESSPSSSE------DEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAV 1225

  Fly   342 RARKIRPDAEVETSEVILPCED---------SLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQE 397
            .:..:..:.::|| |.:.|.|.         .:|.::|...|:.|:||...|:.:.|:..:...:
Human  1226 DSLGMEEEVDIET-EAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAK 1289

  Fly   398 ELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKT 462
            |:...|               .|..:.:|..:::.|   |:|..          :|||.:.....
Human  1290 EVEARP---------------PLSPERAPEHDLEVE---PEPPM----------MLPLPLQPPLP 1326

  Fly   463 PPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRC 527
            ||    |..:.|....|.||:                       ..|...:.|.| :.|:.....
Human  1327 PP----RPPRPPSPPPEPETT-----------------------DASHPSVPPEP-LAEDHPPHT 1363

  Fly   528 EFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKK 592
            ......:.:....|:..|..|. |.|.:||:...|.:|.|    ..||.|    .:||.:.::..
Human  1364 PGLCGSLAKSQSTETVPATPGG-EPPLSGGSSGLSLSSPQ----VPGSPF----SYPAPSPSLSS 1419

  Fly   593 --------RLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQ 649
                    |.||.:....|..|..:     ||.||
Human  1420 GGLPRTPGRDFSFTPTFSEPSGPLL-----LPVCP------------------------------ 1449

  Fly   650 RKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTA 714
                           |....|||.|...:|        ...::.|.|             ||...
Human  1450 ---------------LPTGRRDERSGPLAS--------PVLLETGLP-------------LPLPL 1478

  Fly   715 TLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMR 779
            .|     |:..|.....|..|||.                                ||:..|...
Human  1479 PL-----PLPLALPAVLRAQARAP--------------------------------TPLPPLLPA 1506

  Fly   780 PSTSRVSKFIC---LCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVS 841
            |..|      |   :.:||.:  .|.:|.|                   :.|....|:||.
Human  1507 PLAS------CPPPMKRKPGR--PRRSPPS-------------------MLSLDGPLVRPP---- 1540

  Fly   842 YMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELG--DEEDQ 904
                              ||..:    |:.:|      ..|...|..:..::::....  |..:.
Human  1541 ------------------AGAAL----GRELL------LLPGQPQTPVFPSTHDPRTVTLDFRNA 1577

  Fly   905 GVKFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVEN- 968
            |:....|.|..:.|......|                       ::|.:|       .|..::|
Human  1578 GIPAPPPPLPPQPPPPPPPPP-----------------------VEPTKL-------PFKELDNQ 1612

  Fly   969 ----ANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPES 1029
                |..||...|::        ::......:|:.|..|     .....||       ..|:|.:
Human  1613 WPSEAIPPGPRGRDE--------VTEEYMELAKSRGPWR-----RPPKKRH-------EDLVPPA 1657

  Fly  1030 VMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVA 1094
                            .:.|.:|....:                     .|..|:...|.|:.:.
Human  1658 ----------------GSPELSPPQPLF---------------------RPRSEFEEMTILYDIW 1685

  Fly  1095 HSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTS 1159
            :.|..:.....||           |.||                  ..||
Human  1686 NGGIDEEDIRFLC-----------VTYE------------------RLLQ--------------- 1706

  Fly  1160 LHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAV 1224
                                               ||.|    |.|.
Human  1707 -----------------------------------QDNG----MDWL------------------ 1714

  Fly  1225 FLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTP 1289
                                     ||...|.|.||           .|.|..
Human  1715 -------------------------NDTLWVYHPST-----------SLSSAK------------ 1731

  Fly  1290 LHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTF 1354
                                     |.|.:    |.|....:.|.|:.||....:..:   ||..
Human  1732 -------------------------KKKRD----DGIREHVTGCARSEGFYTIDKKDK---LRYL 1764

  Fly  1355 VVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQI----------D 1409
                               |....|.:|..||:              |..|:..          :
Human  1765 -------------------NSSRASTDEPPADT--------------QGMSIPAQPHASTRAGSE 1796

  Fly  1410 RRVSQMRICSCL-DSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCK 1473
            ||..|.|:.|.. .||.|                                    |:...|||..:
Human  1797 RRSEQRRLLSSFTGSCDS------------------------------------DLLKFNQLKFR 1825

  Fly  1474 NRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEAD---RRTDD----- 1530
            .:          ::..|:.....||:.|:..:.....|..|.|:.:..:.||   :|.:|
Human  1826 KK----------KLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGS 1880

  Fly  1531 SYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICF 1595
            ||.|.:|:...|||...||..||.||||.||.....:..|.|    .||..:|.:.|:..|||.:
Human  1881 SYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQ----KKIVIYSKQHINVNEEITY 1941

  Fly  1596 DYGEKFWRVEHRSCVGCRCLTTTCK 1620
            ||  || .:|... :.|.|.:..|:
Human  1942 DY--KF-PIEDVK-IPCLCGSENCR 1962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	24/136 (18%)
		EHMT_ZBD	786..933	CDD:411018	22/151 (15%)
		ANKYR	1063..1322	CDD:440430	27/258 (10%)
		ANK repeat	1088..1120	CDD:293786	5/31 (16%)
		ANK repeat	1124..1153	CDD:293786	2/28 (7%)
		ANK repeat	1155..1196	CDD:293786	0/40 (0%)
		ANK repeat	1199..1249	CDD:293786	2/49 (4%)
		ANK repeat	1251..1283	CDD:293786	7/31 (23%)
		ANK repeat	1285..1316	CDD:293786	0/30 (0%)
		SET_EHMT	1391..1622	CDD:380941	59/248 (24%)
SETD1B	NP_001340274.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068	68..98
		RRM_Set1B	101..193	CDD:409965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..719
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1462		116/625 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1501..1541		13/88 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1606		9/80 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1668		9/59 (15%)
		N-SET	1679..1821	CDD:463344	49/391 (13%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	1745..1750		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1767..1800		8/46 (17%)
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1798..1803		2/4 (50%)
		SET_SETD1	1815..1962	CDD:380946	48/164 (29%)