Protein Alignment G9a and EZH2

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_011514185.1
• Gene: EZH2 / 2146
• HGNCID: 3527
• Length: 759
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 68/212 - (32%)
• Similarity: 94/212 - (44%)
• Gaps: 34/212 - (16%)

  Fly  1399 CIIQQNSVQIDRRVS---QMRI--CSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVI 1458
            |:|.||..:...:.|   |.|.  |.|...|::.:|.|        |.|....       ||.:.
Human   549 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC--------YLAVREC-------DPDLC 598

  Fly  1459 FECN--DVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTA 1521
            ..|.  |......:||||..:|.|::..|.:...:  ..|||:.....|.|..|:..|.|||::.
Human   599 LTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSD--VAGWGIFIKDPVQKNEFISEYCGEIISQ 661

  Fly  1522 MEADRRTD------DSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIA 1580
            .|||||..      .|:.|:|:|...:||...||..||.|||..||.. .:|...:.|:|   |.
Human   662 DEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCY-AKVMMVNGDHR---IG 722

  Fly  1581 FFSCRDIDAGEEICFDY 1597
            .|:.|.|..|||:.|||
Human   723 IFAKRAIQTGEELFFDY 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412
		EHMT_ZBD	786..933	CDD:411018
		ANKYR	1063..1322	CDD:440430
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		SET_EHMT	1391..1622	CDD:380941	68/212 (32%)
EZH2	XP_011514185.1	EZH2_WD-Binding	47..76	CDD:463308
		PRC2_HTH_1	166..257	CDD:436286
		preSET_CXC	572..603	CDD:408079	10/45 (22%)
		SET_EZH2	622..741	CDD:380995	45/124 (36%)