DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and Kmt2a

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_001344478.1 Gene:Kmt2a / 214162 MGIID:96995 Length:3966 Species:Mus musculus


Alignment Length:1979 Identity:367/1979 - (18%)
Similarity:605/1979 - (30%) Gaps:689/1979 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NSMSSTFNSD-CATSTAEGG-----------TLLNLNL------AEDKTLKWRNLANNQFASKE- 54
            |..||:.::| .|.|||..|           |...||:      ||..|:        .|:||: 
Mouse  2306 NRTSSSKSTDGSAHSTAYPGIPKLTPQVHNATPGELNISKIGSFAEPSTV--------PFSSKDT 2362

  Fly    55 ---------------KKHKDKEEEERKEARNQEEIEDIK--------ALLADVVDAAAVKLEEEE 96
                           .:|.|..:..:.......||:.:|        ::|.:.:.:::....::.
Mouse  2363 VSYPQLHLRGQRSDRDQHMDPSQSVKPSPNEDGEIKTLKLPGMGHRPSILHEHIGSSSRDRRQKG 2427

  Fly    97 AQNAEKV--EPH-TKCEIE-------EEGRKEMEYDQDV-------AKQDSEMEKKQNG------ 138
            .:::::.  |.| :|..:|       |||..:.|:..:|       .:..:.:..::.|      
Mouse  2428 KKSSKETCKEKHSSKSYLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNNVSSEKIGDKVLPL 2492

  Fly   139 ----KATSITVKMESNE-RAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLE 198
                |..|..|:..|.| :|.:..:...|......||:|        |..:||..|...|..:..
Mouse  2493 SGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMEGENQS--------KNTQKESGPGSPAHIESV 2549

  Fly   199 ANAEPLTTTRIEVAVASPLVVSSASVKLAAD--ATNQMRAATSAGAATLADKNVQVSPGGTRR-- 259
            ..|||::.:|  ...|.|.|..|.:..|:.|  :.|.......       |:|:.: |.|.:.  
Mouse  2550 CPAEPVSASR--SPGAGPGVQPSPNNTLSQDPQSNNYQNLPEQ-------DRNLMI-PDGPKPQE 2604

  Fly   260 ----SRRTPR--------------PIDTPTSVTDEHVQVENKKFGK------SEQYTDCSSHLER 300
                .||.||              |:....|..:|.:...:...||      :|...|.:..|..
Mouse  2605 DGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSNSTGKKRGKRSAEGQVDGADDLST 2669

  Fly   301 FTLDD-------NTAI-----VRL------QLKSEPDKPSLTAL--------------SPEENSA 333
            ...||       .|.|     .||      :.:.:.|.|.::.|              :....|:
Mouse  2670 SDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATSRKSS 2734

  Fly   334 PAPKR-----GRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEP-IDQQQLSDLVVV 392
            ..|||     |....:..||:...|...||   :.::|.|         :|| :|  ....:..|
Mouse  2735 QIPKRNGKENGTENLKIDRPEDAGEKEHVI---KSAVGHK---------NEPKLD--NCHSVSRV 2785

  Fly   393 KTEQEELGDAPLGDVKRMRRSVRLGNRLH----ADGSPWEEVKTEALHPQPSAELSFAEVTSEIL 453
            |.:.::..:|.|..::..|       |:|    :|.:..:....|.|  :..::.:.::....||
Mouse  2786 KAQGQDSLEAQLSSLESSR-------RVHTSTPSDKNLLDTYNAELL--KSDSDNNNSDDCGNIL 2841

  Fly   454 PLAVLD---EKTPPKKRGRKAKTPCVKLESETSCGLPFANG----NKKTNSSGGCEL---QLPKR 508
            |..::|   :.||..:  ...::|    ||.:|..|....|    :.:....|..|:   |||..
Mouse  2842 PSDIMDFVLKNTPSMQ--ALGESP----ESSSSELLTLGEGLGLDSNREKDIGLFEVFSQQLPAT 2900

  Fly   509 SKRRIKPTPKILENDELRCEFE---------TKHIERMTQWESAAAVDGDFETPTTGGNGSNSST 564
            .......:..|...::.....|         |:.....:|..|..||..|        :|....|
Mouse  2901 EPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISD--------SGEKRVT 2957

  Fly   565 SRQKSDKSDGSNFEGGPG------HPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQ 623
            ..:||..|.    ||.|.      .||....:....|.:...|.::..:        |||..|||
Mouse  2958 ITEKSVASS----EGDPALLSPGVDPAPEGHMTPDHFIQGHMDADHISS--------PPCGSVEQ 3010

  Fly   624 FLNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHLKHLGLQ---------KNHRDEPSDNDS- 678
            ...:.:....|:. :|                        |||         :|.:..||..|| 
Mouse  3011 GHGNSQDLTRNSG-TP------------------------GLQVPVSPTVPVQNQKYVPSSTDSP 3050

  Fly   679 --SNTDNEFFPTTRVQVGKPS---------------VTLRVRNSVTKELPTTATLKSRRNPVVQA 726
              |...|....||...: ||:               |...:.|.||:::..|:.:.|  .|.|..
Mouse  3051 GPSQISNAAVQTTPPHL-KPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSS--TPSVME 3112

  Fly   727 AKLTRRIGARAAG-EVTEAARASVP-------------ISTPDAEQLHSLDTSIQADVTPIRDLD 777
            .. |..:|...:| .:|.....|:|             :|.|..:.|||...:.|:...|  ::.
Mouse  3113 TN-TSVLGPMGSGLTLTTGLNPSLPPSPSLFPPASKGLLSVPHHQHLHSFPAAAQSSFPP--NIS 3174

  Fly   778 MRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGC-CNELSSEVHNLLRPSQRVS 841
            ..||...:.     .|.|.                   |.|.:|. .|:.:.....:..||..: 
Mouse  3175 SPPSGLLIG-----VQPPP-------------------DPQLLGSEANQRTDLTTTVATPSSGL- 3214

  Fly   842 YMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGV 906
                    |||..|.                                 |.|...|:|...     
Mouse  3215 --------KKRPISR---------------------------------LHTRKNKKLAPS----- 3233

  Fly   907 KFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTV---EN 968
              |:|        ..:...:..|.:|:             ....|::|:....|...|::   .:
Mouse  3234 --SAP--------SNIAPSDVVSNMTL-------------INFTPSQLSNHPSLLDLGSLNPSSH 3275

  Fly   969 ANTPGATARNKGGL---------------STAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALN 1018
            ...|....|:|.|:               .||.|.:.:|:.:..|:....|......|.|     
Mouse  3276 RTVPNIIKRSKSGIMYFEQAPLLPPQSVGGTAATAAGSSTISQDTSHLTSGPVSALASGS----- 3335

  Fly  1019 SINFAQLIPESVMNVV-------------LRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEI 1070
                      ||:|||             :.|||..|:.|:..  ||          |:..::.:
Mouse  3336 ----------SVLNVVSMQTTAAPTSSTSVPGHVTLANQRLLG--TP----------DIGSISHL 3378

  Fly  1071 L---------AADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTA 1126
            |         ..|..|..|       ....:....||.|.........|||              
Mouse  3379 LIKASHQSLGIQDQPVALP-------PSSGMFPQLGTSQTPSAAAMTAASS-------------- 3422

  Fly  1127 LMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSF 1191
             :|.:.:.:.          |.:....|.|:...|...|.||    ||:.....|   :||... 
Mouse  3423 -ICVLPSSQT----------AGMTAASPPGEAEEHYKLQRGN----QLLAGKTGT---LTSQRD- 3468

  Fly  1192 IDAQDEGGWTAMVWAAELGHTDIVRL---ASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNN 1253
            .|.....|.....:.......:.|||   .:||.|.          .:...:..:.|:......:
Mouse  3469 RDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPSAK----------PASSASPGSSPSSGQQSGS 3523

  Fly  1254 TVLHWSTLHNDGLDTITVLLQ--SGADCNVQNVEGDTPLHI-------ACRHSVTRMCIALIANG 1309
            :.:...|........|.:.|.  ||....|.::...:..||       |.:.||||...|     
Mouse  3524 SSVPGPTKPKPKAKRIQLPLDKGSGKKHKVSHLRTSSEAHIPHRDTDPAPQPSVTRTPRA----- 3583

  Fly  1310 ADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASNGREARP-IQVVR 1373
                  |:.:|.........:.|||:..|         |:.               |.| :|..:
Mouse  3584 ------NREQQDAAGVEQPSQKECGQPAG---------PVA---------------ALPEVQATQ 3618

  Fly  1374 NELAMSEN------EDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQ-C 1431
            |.....||      |:|......|...::.|  .|:....|..|..:..:  ..:..|.|..| |
Mouse  3619 NPANEQENAEPKAMEEEESGFSSPLMLWLQQ--EQKRKESITERKPKKGL--VFEISSDDGFQIC 3679

  Fly  1432 NGASSQNWYT-----AESRLNADFNYED--------------PAVIFECNDVCGCN--------- 1468
            ..:....|.:     .|:|.||......              .||:|....:.|..         
Mouse  3680 AESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRF 3744

  Fly  1469 ------------------------------------------------------QLSCKNRVVQN 1479
                                                                  ||....|....
Mouse  3745 HKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSM 3809

  Fly  1480 GTRTPLQIVECEDQAK-----------GWGVRALANVPKGTFVGSYTGEILTAMEADRRTD--DS 1531
            ....|::....:..:|           |.|:....|:..|..|..|.|.::.:::.|:|..  ||
Mouse  3810 DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDS 3874

  Fly  1532 -----YYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGE 1591
                 |.|.:|:...:||..:||..||.|||||||.....:..:.|.:    |..|:.|.|..||
Mouse  3875 KGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKH----IVIFAMRKIYRGE 3935

  Fly  1592 EICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
            |:.:||  ||...:..:.:.|.|....|:
Mouse  3936 ELTYDY--KFPIEDASNKLPCNCGAKKCR 3962

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 22/100 (22%)
Ank_2 1056..1152 CDD:289560 13/104 (13%)
ANK 1088..1217 CDD:238125 22/128 (17%)
ANK repeat 1088..1120 CDD:293786 6/31 (19%)
ANK repeat 1124..1153 CDD:293786 2/28 (7%)
Ank_2 1127..1249 CDD:289560 22/124 (18%)
ANK 1155..1306 CDD:238125 33/162 (20%)
ANK repeat 1155..1196 CDD:293786 11/40 (28%)
ANK repeat 1199..1249 CDD:293786 8/52 (15%)
Ank_2 1205..1316 CDD:289560 21/122 (17%)
ANK repeat 1251..1283 CDD:293786 6/33 (18%)
ANK repeat 1285..1316 CDD:293786 8/37 (22%)
PreSET 1357..1466 CDD:128744 25/135 (19%)
SET 1495..1602 CDD:214614 39/124 (31%)
Kmt2aNP_001344478.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..106
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q03164 6..25
Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250|UniProtKB:Q03164 121..132
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..231
Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250|UniProtKB:Q03164 145..150
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..343
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..590
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..943
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1003
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1064
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1101..1161
zf-CXXC 1144..1191 CDD:251032
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1196..1390
PHD1_KMT2A 1432..1478 CDD:277063
PHD2_KMT2A 1480..1529 CDD:277065
PHD3_KMT2A 1567..1626 CDD:277067
Interaction with histone H3K4me3. /evidence=ECO:0000250|UniProtKB:Q03164 1583..1599
Bromo_ALL-1 1649..1779 CDD:99925
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1665..1714
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1807..1870
ePHD_KMT2A 1873..1985 CDD:277163
FYRN 2026..2073 CDD:310506
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2147..2174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2214..2339 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2371..2619 50/265 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2673 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2709..2759 8/49 (16%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:Q03164 2843..2851 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2958..3060 28/138 (20%)
Herpes_BLLF1 <3152..>3361 CDD:330317 52/319 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3164..3239 22/157 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3462..3640 41/226 (18%)
FYRC 3666..3749 CDD:197781 13/84 (15%)
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q03164 3759..3764 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3782..3805 2/22 (9%)
SET 3828..3948 CDD:214614 39/125 (31%)