DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Suv39h1

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_011245754.1	Gene:	Suv39h1 / 20937	MGIID:	1099440	Length:	432	Species:	Mus musculus

Alignment Length:	259	Identity:	94/259 - (36%)
Similarity:	124/259 - (47%)	Gaps:	48/259 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 REARPIQVVRNELAMSENEDEADSLMWP--DFRYVTQCIIQQ----NSVQIDRRVSQMRICSCLD 1422
            |..:.:...|:.|.....|:|.| |..|  .|.|:.:..:.:    |.|.:.        |.|.|
Mouse   131 RWEQELNAKRSHLGRITVENEVD-LDGPPRSFVYINEYRVGEGITLNQVAVG--------CECQD 186

  Fly  1423 S--CSSDRCQCNGASSQNWYTAESRLNADFNYEDPA--------VIFECNDVCGCNQLSCKNRVV 1477
            .  ..:..| |.|||...           |.|.|..        .|:|||..|.|. ..|.||||
Mouse   187 CLLAPTGGC-CPGASLHK-----------FAYNDQGQVRLKAGQPIYECNSRCCCG-YDCPNRVV 238

  Fly  1478 QNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADR------RTDDSYYFDL 1536
            |.|.|..|.|....| .:|||||.|..:.|.:||..|.|||:|:.||:|      |...:|.|||
Mouse   239 QKGIRYDLCIFRTND-GRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDL 302

  Fly  1537 D---NGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDY 1597
            |   :.:.:||.||||::.|.||||:||:....||.::.|.|.|:||||:.|.|.||||:.|||
Mouse   303 DYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDY 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744	27/117 (23%)
		SET	1495..1602	CDD:214614	54/112 (48%)
Suv39h1	XP_011245754.1	CD_SUV39H1_like	44..92	CDD:349289
Suv39h1	XP_011245754.1	SET	159..372	CDD:394802	86/230 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850