DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Setd1b

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_006530300.1	Gene:	Setd1b / 208043	MGIID:	2652820	Length:	1986	Species:	Mus musculus

Alignment Length:	1605	Identity:	292/1605 - (18%)
Similarity:	459/1605 - (28%)	Gaps:	629/1605 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 MRAATSAGAATLADKNV-------QVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGKS--- 288
            |.||.:|.:|.|...|:       .:|..|..|.:..| |:               .||..|
Mouse   789 MAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWP-PL---------------PKFDPSVPP 837

  Fly   289 EQYTDCSSHLERFTLDDNTAIVRLQLKS------------------------EPDKPSLTALSP- 328
            ..|........:.|:|....:|..:||:                        :.::.:..:|:|
Mouse   838 PGYIPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPV 902

  Fly   329 -----EENSAPAPK------------RGRGRARK-----------IR-PDAEVETSEVILPCEDS 364
                 ::...|.||            :|.|...:           || |..:|:..|.  |...|
Mouse   903 KSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEP--PDTAS 965

  Fly   365 LGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQE---ELGDAPLGDVKRMRRSV----RLGNRLHA 422
            .|:    :||..|...:|::.      .::|:|   ::.|||....||..:||    |.|..|..
Mouse   966 SGD----QKRLRPSTSVDEED------EESERERDRDIADAPCELTKRDPKSVGVRRRPGRPLEL 1020

  Fly   423 DGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSCGLP 487
            | |..||.:.|:|....|:..|.:..:|...|.:...:|....:...:.:    :.|.|......
Mouse  1021 D-SGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEDRESTEEE----EEEEEEEAEEE 1080

  Fly   488 FANGNKKTNSSGGCELQLPKRSKRRIKPTPKILEND---ELRCEFETK--HIERMTQWESAAAVD 547
            ...|.:...||       |..|....|......|.|   ::..:.:.:  .:...::.::..:.:
Mouse  1081 EEEGPRSRISS-------PSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEE 1138

  Fly   548 GDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSA-----------IKKRLFSKSQRD 601
            .:.|:.||....:.||:|  .|:.|..|.||......:.:|:           :::....:.:.:
Mouse  1139 EETESITTSKAPAESSSS--SSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEE 1201

  Fly   602 IENYGAA----MLAKSKLPPC--PDVEQFLNDIKASRINANRSPEERKLNKKQQRKL-------- 652
            .|...||    .:|:..:||.  .|.||...::..    ..|.|....|..:::..:
Mouse  1202 KETAMAAATVVAMAEESMPPAGGQDFEQDRAEVPL----GPRGPMRESLGTEEEVDIEAEDEVPE 1262

  Fly   653 --AKQKEKHLKHLGLQK-NHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTA 714
              |.:.|:....:|.:| ....||.:....||..:..                   ::.|||
Mouse  1263 MQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDML-------------------LSPELP--- 1305

  Fly   715 TLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMR 779
                                   |.|..||...|.|...|::      |..::.:..|:..|.::
Mouse  1306 -----------------------ARETEEAQLPSPPEHGPES------DLDMEPEPPPMLSLPLQ 1341

  Fly   780 PSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMI 844
            |..           .|.:                                   ||||.
Mouse  1342 PPL-----------PPPR-----------------------------------LLRPP------- 1353

  Fly   845 LCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFS 909
                                                          |...|.|..:.....|...
Mouse  1354 ----------------------------------------------SPPPEPETPEPPKPPVPLE 1372

  Fly   910 SPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGA 974
            .|      |.   |.|.||..:   |.||   .::|..:..||                  |||.
Mouse  1373 PP------PE---DHPPRTPGL---CGSL---AKSQSTETVPA------------------TPGG 1404

  Fly   975 TARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHV 1039
            .....|. |:.::||:...|.|..:........:|....|......:|....||
Mouse  1405 EPPLSGS-SSGLSLSSPQVPGSPFSYPSPSPGLSSGGLPRTPGRDFSFTPTFPE----------- 1457

  Fly  1040 VSASGRVTAEFTP-----RDMYYAVQNDDLERVAEI---------------------LAADFNVL 1078
              .||.:.....|     ||          ||...:                     ||....||
Mouse  1458 --PSGPLLLPVCPLPTGRRD----------ERTGPLASPVLLETGLPLPLPLPLPLPLALPVPVL 1510

  Fly  1079 ----------------------TPIRE-------------YLNGTCLHLVAHSGTLQMAYLLLCK 1108
                                  |||:.             .|:|..:.  ...|......|||..
Mouse  1511 RAQPRPPPQLPPLLPATLAPCPTPIKRKPGRPRRSPPSMLSLDGPLVR--PPPGPALGRDLLLLP 1573

  Fly  1109 G-ASSPDFVN-----IVDYELRTALMCA-----------------VMNEKCDMLNLFLQCGADVA 1150
            | ..:|.|.:     .|..:.|...:.|                 |.:.|.....|..|..::..
Mouse  1574 GQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQPPPPPPPPPVESTKLPFKELDNQWPSEAI 1638

  Fly  1151 IKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIV 1215
            ..||...            |.|:..||.               |:..|.|..   ..:..|.|:|
Mouse  1639 PPGPRRD------------EVTEEYVDL---------------AKVRGPWRR---PPKKRHEDLV 1673

  Fly  1216 RLA-----SLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLH--WSTLHNDGLD------ 1267
            ..:     |.||.:|                  .|. .:.:..|:|:  |    |.|:|
Mouse  1674 APSASPEPSPPQPLF------------------RPR-SEFEEMTILYDIW----NGGIDEEDIRF 1715

  Fly  1268 ---TITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNE 1329
               |...|||..   |..:...||   :...|..|.:..|.         |.|.|    |.|...
Mouse  1716 LCVTYERLLQQD---NGMDWLNDT---LWVYHPSTSLSSAK---------KKKRE----DGIREH 1761

  Fly  1330 ESECGRTVGF-----NMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLM 1389
            .:.|.|:.||     ..::|........|.....|...|... |.|...:..|.||
Mouse  1762 VTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPMDTQQGMSI-PAQPHASTRAGSE--------- 1816

  Fly  1390 WPDFRYVTQCIIQQNSVQIDRRVSQMRICSCL-DSCSSDRCQCNGASSQNWYTAESRLNADFNYE 1453
                                ||..|.|:.|.. .||.|
Mouse  1817 --------------------RRSEQRRLLSSFTGSCDS--------------------------- 1834

  Fly  1454 DPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEI 1518
                     |:...|||..:.:          ::..|:.....||:.|:..:.....|..|.|:.
Mouse  1835 ---------DLLKFNQLKFRKK----------KLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQN 1880

  Fly  1519 LTAMEAD---RRTDD-----SYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYR 1575
            :..:.||   :|.:|     ||.|.:|:...|||...||..||.||||.||.....:..|.|
Mouse  1881 IRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQ--- 1942

  Fly  1576 FPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
             .||..:|.:.|:..|||.:||  || .:|... :.|.|.:..|:
Mouse  1943 -KKIVIYSKQHINVNEEITYDY--KF-PIEDVK-IPCLCGSENCR 1982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	6/13 (46%)
		Ank_2	1056..1152	CDD:289560	25/174 (14%)
		ANK	1088..1217	CDD:238125	26/151 (17%)
		ANK repeat	1088..1120	CDD:293786	7/37 (19%)
		ANK repeat	1124..1153	CDD:293786	6/45 (13%)
		Ank_2	1127..1249	CDD:289560	22/143 (15%)
		ANK	1155..1306	CDD:238125	31/166 (19%)
		ANK repeat	1155..1196	CDD:293786	5/40 (13%)
		ANK repeat	1199..1249	CDD:293786	9/54 (17%)
		Ank_2	1205..1316	CDD:289560	24/126 (19%)
		ANK repeat	1251..1283	CDD:293786	11/42 (26%)
		ANK repeat	1285..1316	CDD:293786	5/30 (17%)
		PreSET	1357..1466	CDD:128744	16/109 (15%)
		SET	1495..1602	CDD:214614	39/114 (34%)
Setd1b	XP_006530300.1	RRM_Set1B	100..192	CDD:240993
		N-SET	1698..1841	CDD:371711	43/231 (19%)
		SET_SETD1	1835..1982	CDD:380946	48/164 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930