DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment G9a and set-15

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001370771.1	Gene:	set-15 / 187813	WormBaseID:	WBGene00020006	Length:	611	Species:	Caenorhabditis elegans

Alignment Length:	453	Identity:	103/453 - (22%)
Similarity:	161/453 - (35%)	Gaps:	121/453 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1277 ADCNVQN-VEGDTPLHIACRHSVTRMCIALIANG-----ADLMIKNKAE-----QLPFDCIPNEE 1330
            |:|:|:| ::.|..|.    ....|.|..||...     ||:|..:.|.     .:|....|.:.
Worm   174 AECSVRNAIKSDPELD----GFYVRTCGKLINKTVLNTMADMMDNHMATTRLLWNMPRHEFPVDF 234

  Fly  1331 SECGRTVGFNMQMRSFRPLGLRTFV----------VCADASNGREARPIQVVRNELAMSENEDEA 1385
            .|  :.|.|.:.: |:.|...|.||          ...|.. |...|.|.:....:......:..
Worm   235 HE--KFVDFALNV-SYTPPKKRIFVEKKLFEKSISTFTDIP-GETHRTISLGNTFVYKYTERNVV 295

  Fly  1386 DSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRC---------QCNGASSQNWYT 1441
            |...:|:...:|:...:.|:|        :| |.|..|.|..:|         |.|....:....
Worm   296 DVEKYPELHALTEEAERPNNV--------IR-CECCSSGSIKKCWNNPDCFCFQMNLKLRKEQDP 351

  Fly  1442 AESRLNADFNYEDPAVI-----------FECNDVCGCNQLSCKNRVVQNGTRTPLQIVE-----C 1490
            ..::|..||:..||..|           |.|::.|.|.. .|.|.:    |..|.:.:.     .
Worm   352 KNNKLLTDFSTFDPVFIRERNHFFDTIGFACSENCACGG-KCTNNI----TLLPEKNINKFEIYR 411

  Fly  1491 EDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDN-GH-------------- 1540
            :::..|:.:|.|.::|.||.|..:|||::.....| ..|..|.|::.| .|
Worm   412 KNEIMGFAIRTLNSIPAGTPVMEFTGELMDFDILD-NIDQDYAFEIVNEAHNLHETLPNFNKRWS 475

  Fly  1541 ---------------CIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAG 1590
                           .::....|||.|...|||:||:..||||.:.......|:...:..||..|
Worm   476 ENFKSSLKKQLARPWFVNPKRIGNVARICCHSCQPNMAMVRVFQKGFSPAHCKLLLVTLEDIFPG 540

  Fly  1591 EEICFDYGEKFWRVEHRSCVGCRCLTTTCKYASQSSSTNASPTNATTAPENETGTLSSTNTEK 1653
            .|:.||||..:.. |.:.  ||.|....|                   |..|:..:.|..|:|
Worm   541 VELTFDYGPGYLN-ELKG--GCLCERIGC-------------------PNTESFGILSRATKK 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125	8/29 (28%)
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560	13/44 (30%)
		ANK repeat	1251..1283	CDD:293786	3/5 (60%)
		ANK repeat	1285..1316	CDD:293786	9/35 (26%)
		PreSET	1357..1466	CDD:128744	25/128 (20%)
		SET	1495..1602	CDD:214614	38/136 (28%)
set-15	NP_001370771.1	SET	405..554	CDD:214614	38/150 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740