DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment G9a and set-11

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001364763.1	Gene:	set-11 / 185242	WormBaseID:	WBGene00018023	Length:	278	Species:	Caenorhabditis elegans

Alignment Length:	281	Identity:	91/281 - (32%)
Similarity:	131/281 - (46%)	Gaps:	43/281 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1355 VVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICS 1419
            |:..|.|.|.|...:.|..|....      .||.::.:|:| |..||........|..|...:|.
Worm    19 VLYEDISQGCERFVVPVYSNPRFF------MDSSLFENFKY-TSRIIDVAGQLACRSASPTFMCQ 76

  Fly  1420 CLDSCSSDRCQCN------GASSQN-----WYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCK 1473
            |...||:: |:|:      |.:.:|     |.|                :.|||:.|.| .|.|.
Worm    77 CAGQCSTN-CECSSGVFGEGGTVENMELLMWDT----------------VRECNEYCNC-ALWCG 123

  Fly  1474 NRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDN 1538
            |||.|.|...|::|. ..|...||||||..::..|||:|.|.||::...||..|.|.::.|:...
Worm   124 NRVAQKGAMYPVEIF-ARDPWCGWGVRASVDIAFGTFIGEYAGELIDDEEAMDRHDSTFLFETKV 187

  Fly  1539 GH---CIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEK 1600
            |.   .|||.|.||.|||.||||.|||....:.:::...:...:.||:.:.|..|||:..||||.
Worm   188 GSETLTIDAKYSGNYTRFINHSCAPNVKVANISWDYDKIQLIHMCFFTDKAIRKGEELTIDYGEA 252

  Fly  1601 FWRVEHRSCVGCRCLTTTCKY 1621
            :|..:...|:   |.::.|:|
Worm   253 WWANKKFPCL---CKSSECRY 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744	28/119 (24%)
		SET	1495..1602	CDD:214614	45/109 (41%)
set-11	NP_001364763.1	PreSET	21..117	CDD:128744	28/119 (24%)
set-11	NP_001364763.1	SET	75..270	CDD:394802	74/216 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165862
Domainoid	1	1.000	90	1.000	Domainoid score	I4936
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4686
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto17911
orthoMCL	1	0.900	-	-		OOG6_105922
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X1720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.630