DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and set-19

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001379854.1	Gene:	set-19 / 180834	WormBaseID:	WBGene00020919	Length:	953	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	91/451 - (20%)
Similarity:	149/451 - (33%)	Gaps:	162/451 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1335 RTVGFNMQMRSFRPLGLRTFVVCADASNGREARP---IQVVRNELA--MSENEDEADS--LMWPD 1392
            |||    :|.:.||           :|..:|.||   :.:::.:..  :||..||..:  ..||:
Worm    11 RTV----RMNAIRP-----------SSKEKEQRPTPKLPLIKGKSVPMISELPDEEQNHRSKWPE 60

  Fly  1393 F------------RYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSD-RCQC--NGASSQNWYTA 1442
            .            .|:::...:...:.::||......|...|.||.: .|:|  .|...|.::
Worm    61 TATFVTIERNVLGNYISESAKEAIEMGLNRRNKVCCDCGPDDDCSKNPDCKCYQMGKELQKYF-- 123

  Fly  1443 ESRLNADF-NYEDPAVI----------FECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQ--- 1493
                .:|| .|..|..|          |.|::.|||.. .|.    .||.:   .|.:..|:
Worm   124 ----KSDFLVYGKPVKIMDSMYWDGPMFACSEGCGCRG-DCD----LNGLK---DIDKDHDKKYN 176

  Fly  1494 -----AKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-TDDSYYFDLDNG-----------HC 1541
                 .||:.:..:..:.||..|.::.|||......::: ..:.|...|..|           :.
Worm   177 VTRRDGKGFCLFTMFQIEKGQPVLAFNGEITGYHSINKKPAVEQYALQLSEGDPRLSSFIRDCNV 241

  Fly  1542 IDANY------------------YGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDID 1588
            ::.:|                  .||..||.:|:|:.|:...|||.....:...:|..|:...|.
Worm   242 LNKDYKDVLRNALETKLWVNPLEKGNCARFLSHACQANLELGRVFQGGFSFADVRIVLFAKETIP 306

  Fly  1589 AGEEICFDYG----EKFWRVEHRSCVGCRCLTTT------------------------CKYASQS 1625
            ||.|:.|.||    |||.   ...|:...|...|                        ||.|...
Worm   307 AGSELTFHYGPDYKEKFL---EDLCLCYTCFVPTIVRTSRRIARKRAYVREPTPESERCKRARDR 368

  Fly  1626 SSTNASPTNA-------------------------------TTAPENETGTLSSTNTEKIG 1655
            |...|....|                               |.:|||:...:.|:::...|
Worm   369 SIIAAETIEAEIEEAHEKRMALKARKAFLLKRKLRKSNVRRTESPENKRSPVQSSSSSSSG 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744	28/141 (20%)
		SET	1495..1602	CDD:214614	33/140 (24%)
set-19	NP_001379854.1	SET	175..322	CDD:214614	31/146 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740