DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment G9a and set-13

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_494371.1	Gene:	set-13 / 173626	WormBaseID:	WBGene00019690	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	80/368 - (21%)
Similarity:	127/368 - (34%)	Gaps:	106/368 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1341 MQMRSFRPLGLRTFVVCADASNGREARPIQVVRNE-LAMSEN-EDEA--DSLMWPD---FRYVTQ 1398
            |..|:.|.......:.........||..|.|.:.. :.|:.| .|:|  |..|||.   |..:..
Worm    32 MSSRTLRSSSSSNAISTKTQPKTEEAPLIPVTKGPVIRMTSNMADKAQNDHSMWPSTSKFESIWG 96

  Fly  1399 CIIQQ-----------NSVQIDRRVSQMRICSCL--DSCSSD-RCQCNGASSQNWYTAESRLNAD 1449
            .::.:           ..::|:.:|:    |.|.  ..||:: .|:|        :...|||...
Worm    97 NVLGERVNKSTIAAIREGMKIENKVT----CGCRPGQDCSTNPACRC--------FQTASRLREH 149

  Fly  1450 FN-----------------YEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQA--- 1494
            |.                 ::.|  :|.|:..|||.. .|....:|:         .|||.|
Worm   150 FGSDILTRGKPVKTVDTMYWDRP--MFACSGSCGCKG-QCNLNALQD---------ICEDPAKKF 202

  Fly  1495 -------KGWGVRALANVPKGTFVGSYTGEILTAMEADRRTD-DSYYFDLDNGHCIDANYY---- 1547
                   ||:.|.:...:.||:.|..::|||...:......| :.|...|.|......:::
Worm   203 KITRTDGKGFCVYSARVIKKGSPVLEFSGEITDYLAIKSNADIEQYSIMLYNNETKLCDFFSKEE 267

  Fly  1548 -------------------------GNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDI 1587
                                     ||..|||:|.|:.|:...|||.........||..|:...|
Worm   268 NLSSKYKKILWSAYRSKAWINPLNRGNCARFFSHGCKANMELGRVFQGGFSPADMKIVLFAKEII 332

  Fly  1588 DAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCKYASQSSSTNA 1630
            ..|.|:.|:||..:..:    .:|.:||...||..:.....||
Worm   333 KPGTELTFNYGPSYKEI----FLGNKCLCEACKKEAVKKLENA 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744	28/146 (19%)
		SET	1495..1602	CDD:214614	33/136 (24%)
set-13	NP_494371.1	SET	200..348	CDD:214614	33/147 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740