Protein Alignment G9a and Ezh1

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: NP_031996.1
• Gene: Ezh1 / 14055
• MGIID: 1097695
• Length: 750
• Species: Mus musculus
• Alignment Length: 220
• Identity: 69/220 - (31%)
• Similarity: 97/220 - (44%)
• Gaps: 50/220 - (22%)

  Fly  1399 CIIQQNSVQIDRRVS---QMRI--CSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVI 1458
            ||:.||..:...:.|   |.|.  |.|...|::.:|.|        |.|               :
Mouse   540 CIMTQNFCEKFCQCSPDCQNRFPGCRCKTQCNTKQCPC--------YLA---------------V 581

  Fly  1459 FECN-DVC---------GCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGS 1513
            .||: |:|         .|..:||||..:|.|.:..|.:...:  ..|||.....:|.|..|:..
Mouse   582 RECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSD--VAGWGTFIKESVQKNEFISE 644

  Fly  1514 YTGEILTAMEADRRTD------DSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQ 1572
            |.||:::..|||||..      .|:.|:|:|...:||...||..||.|||..||.. .:|...:.
Mouse   645 YCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCY-AKVVMVNG 708

  Fly  1573 DYRFPKIAFFSCRDIDAGEEICFDY 1597
            |:|   |..|:.|.|.||||:.|||
Mouse   709 DHR---IGIFAKRAIQAGEELFFDY 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412
		EHMT_ZBD	786..933	CDD:411018
		ANKYR	1063..1322	CDD:440430
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		SET_EHMT	1391..1622	CDD:380941	69/220 (31%)
Ezh1	NP_031996.1	EZH2_WD-Binding	42..71	CDD:463308
		PRC2_HTH_1	162..265	CDD:436286
		SANT	436..477	CDD:238096
		preSET_CXC	563..594	CDD:408079	11/53 (21%)
		SET_EZH1	611..746	CDD:380994	46/126 (37%)