Protein Alignment G9a and ash1

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_061503996.1
• Gene: ash1 / 1281642
• VectorBaseID: AGAMI1_008353
• Length: 3636
• Species: Anopheles gambiae
• Alignment Length: 1970
• Identity: 385/1970 - (19%)
• Similarity: 617/1970 - (31%)
• Gaps: 658/1970 - (33%)

  Fly    18 DCATSTA-EGGTLL---NLNLAEDKTLKWRNLANNQF---------------------------- 50
            |.|...| |||.||   .|.|::...:|.....:.:|
Mosquito  1302 DAAKDDAEEGGRLLGVKKLPLSKANVIKNSEECSRRFQKSTSSFALGGIAGSVDLLARIADGTIP 1366

  Fly    51 -ASKEKKHKDKEEEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEE 114
             ||..|....|....:..|.::.|:..:|:.  .|:.:.. |:.:      .::...::|.....
Mosquito  1367 KASPTKSVCSKRSRRKSCASDRLEVMSVKSY--GVIGSCG-KIRQ------RRLSTMSRCSSRSA 1422

  Fly   115 G----------RKEMEYDQDVAK-QDSEMEK--------KQNGKATSITVKMESNERAEKHATEI 160
            |          ||:......||. ..:||..        ...|.|:|..:.::.|       .||
Mosquito  1423 GSRHAAARMRRRKKRLRSMSVAPGTTAEMVSGGGGGNGGAAGGAASSSGLDLKLN-------VEI 1480

  Fly   161 ATTSTERWENESF-------------KTEQQNKKAAEKEEEPILAATQKLEANAEPL------TT 206
            ...|      |||             :..|.:..|......|..|......|.|.|.      |.
Mosquito  1481 DRLS------ESFSGMCRIVGGTVNNEAGQASSGAGRSVSPPEEATATNAPAAATPTSGKGHQTK 1539

  Fly   207 TRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGT--RRSRRTPRPIDT 269
            ..::...||..|..|.|....|:|.    .....|||.|.:.......|||  ||:::|     .
Mosquito  1540 RSVKKRKASEHVTDSPSTAGGANAP----GGGGGGAAALGNGGGAGGGGGTGKRRNKKT-----V 1595

  Fly   270 PTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDK------PSLTAL-- 326
            ||...|:|      |....:::...:...:....|:|:.:..::..|....      .|.||.
Mosquito  1596 PTQSPDDH------KLPLKKRHYLLTPGEKGNNSDNNSGVDEVKTGSSGGNGGGVGGSSATAAGS 1654

  Fly   327 ---SPEENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPG----------------- 371
               |...:::.|...|.|.|.    .:.:.:..|:.||..:.|.:...
Mosquito  1655 NVDSGNSSTSGATGSGSGSAN----SSFIGSHTVLNPCAFASGARSSANSAATGSSISGAATKAV 1715

  Fly   372 --RKRKLPDEPIDQQQLSDLVVVKTE---QEELGDAPL------------GDV-KRMRRSVRLGN 418
              :||.|...|......:|     ||   |.:..|:||            ||. ........:|.
Mosquito  1716 TPKKRHLLKSPEPGPVPTD-----TELQLQIKSSDSPLTIVNGGGASGTVGDAGSSPSDGHTVGR 1775

  Fly   419 RLHADGS--------------PWEEVKTEALHPQPSAELSFAEVTSEI-------LPLAVLDEKT 462
            :...||:              |....|.:....|..:.:|.:.|:.|.       .|....:...
Mosquito  1776 KAAVDGAVGGSPSNAAGQANPPVAGSKKKTNRQQEGSSISSSTVSRERQATGASGQPGTTSENSA 1840

  Fly   463 PPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGG-----------CELQLPKRS------- 509
            .|:.|......|.| ::|..|.. |.|:....:.||.|           .||.:|..|
Mosquito  1841 GPQHRSTPPARPSV-IQSSGSVH-PAASSGAYSASSAGPPPGVFEPTVDLELVIPPPSSIPSLIA 1903

  Fly   510 KRRIKPTPKILEND-----------------ELRCEFETKHIERMTQWESAAAVDGDFETPTTGG 557
            |..:..:|::...|                 .:..:.|::.::.:|..:..||           |
Mosquito  1904 KVEMLDSPRLGGKDVAAAAGAIGSSSSGSSGNVATKLESEELQVLTAAQRKAA-----------G 1957

  Fly   558 NGSNS------STSRQKSDKSDGSNFEGGPGHPAGTSAIKK--------RLFSKSQRDIEN---Y 605
            .|:.|      ||:...|:|                 .::|        .|..|.:|...|   :
Mosquito  1958 LGAGSALLATISTASASSEK-----------------VLEKLLTKTGAHHLLMKKKRKKPNRTGF 2005

  Fly   606 GAAMLAKSKLPPCPDVEQFLN--DIK---------ASRINANRSPEERKLNKKQQRKLAKQKEKH 659
            ......|.|||....::..|:  |:|         :|.:..:...|..|...|:     :|::.|
Mosquito  2006 PTVKKKKKKLPDNDPLDDGLSVLDLKPEVGPDLFDSSNLTRHVPSEAEKTRMKE-----RQQQHH 2065

  Fly   660 L---KHLGLQKNHRD-EPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELP--------- 711
            .   ||....:..:: ||:|         .|......||:|.:::.....:..:||
Mosquito  2066 PSTGKHAACDRVPKEGEPTD---------CFIERHTGVGRPRLSVVSLEKLQGKLPLPGGGSRDV 2121

  Fly   712 -TT--AT----LKSRRNPVVQ----AAKLTRRI----GARAAGEVTEAA--RASVPISTPDA--- 756
             ||  ||    .||..||:..    ||:.:|.:    .|.|||.|....  |...|...|:.
Mosquito  2122 ATTPPATGGRGRKSVINPLAAEHQLAAQRSRGLRDEPPAAAAGTVGRKGKKRQEAPKPLPETAVG 2186

  Fly   757 -EQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQ--------KPSQYYARNAPDSSYCCAI 812
             .|..|:||.|::.....|...:..::.::...:.|.:        |.::..:|..|......|
Mosquito  2187 KRQKASMDTEIRSAKERNRSKSVSVASEQLPNIVRLSETLSKGAAAKENKENSRLPPGRPPSAA- 2250

  Fly   813 DHIDDQKIGCCNELSSE------VHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKF 871
                 ::.|.....|:|      ...::|.: |.|.:.|.....|:|..|:
Mosquito  2251 -----KRAGKEPATSAETAPQDDAAGVIRRT-RSSSVALDPSEVKKLHHHH-------------- 2295

  Fly   872 VLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQG---VKFSSPVLVLKCPHCG----LDTPERTS 929
                     |.|               .:.|..|   .:.|:||.    ||.|    |...:.||
Mosquito  2296 ---------HHD---------------AEHESAGKGASQSSTPVR----PHSGGIAALHNEDSTS 2332

  Fly   930 TVTMKCQSLPVFLR-------------TQKYKIKP------------ARLTTSSHLTQFGTVENA 969
                 ..|:|:..|             |....|:|            .|..|:|.:|   ..|..
Mosquito  2333 -----LDSMPLLKRLHSRSISRMQSVITPTVVIEPIATSPKTPGRPRGRPRTTSPIT---ATETP 2389

  Fly   970 NTPGATA-RNKGGLSTAVTL----SAAS---SPASKTNGAQRGRAGTSNSNSRHALNSINFAQLI 1026
            |:|.||| ..:|...||:.|    ||||   :|||..:......|....:..|.. ..::..:.:
Mosquito  2390 NSPTATAGPGRGRPRTALALTGNPSAASMQRTPASPLSSPSPTVAAAERTAGRKK-QRLDGRKSV 2453

  Fly  1027 PESVMNVVLRGHVVSASGRVTA--EFTPRDMYYAV--------QNDDLERVAEILAADFNVLTPI 1081
            |..:...:....:.:   ||||  ..||......|        ::|:..|..::   :.....|.
Mosquito  2454 PPGLAEPIESARLAT---RVTASKSVTPTPPVGTVIPTRLKRGKSDETLRAQQL---EKPTKKPR 2512

  Fly  1082 REYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCG 1146
            :|                       ..|::.|..........|:|:
Mosquito  2513 KE-----------------------LPGSAEPSPETAAHLSKRSAI------------------- 2535

  Fly  1147 ADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFID--AQDEGGWT---AMVWA 1206
            |...::..|.:.:.|:.....:.|  :|..|........:.||...|  :....|.|   ||..|
Mosquito  2536 ASPIVEPVDPEETAHVLQPASSTE--ELEHDPLPPDEGPSDFLRLTDTPSPTSSGETRELAMGGA 2598

  Fly  1207 AELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITV 1271
            | .|.........||:.   |.|...||           :.|..|:.|.      ..:|
Mosquito  2599 A-AGGRGAGTSKKLPRK---KYITAGLF-----------SDCYKDDGTT------GGEG------ 2636

  Fly  1272 LLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRT 1336
              :||.....:.:   .|....|...:.|..              :..|||:|....:|:  |:.
Mosquito  2637 --RSGPKTPPETL---LPPPAYCERFLRRTV--------------RDFQLPYDLWWLQEN--GKL 2680

  Fly  1337 VGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCII 1401
            .|.| .:.|:....:||.|.....:|                            |.....|||..
Mosquito  2681 PGRN-SVPSWNYRKIRTNVYYDVKAN----------------------------PSTDNNTQCNC 2716

  Fly  1402 QQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFEC-NDVC 1465
            :.:|             .|.|.|                     ||.       .|..|| .:.|
Mosquito  2717 KPDS-------------GCQDDC---------------------LNR-------MVYTECVPEQC 2740

  Fly  1466 GCNQLSCKNRVVQNGTRTP-LQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-- 1527
            .|.. .|:|..:|.....| |:....|:  ||||:|:...:.||||:..|.||::|..|...|
Mosquito  2741 PCGD-RCRNTCIQRHEYAPGLERFMTEE--KGWGIRSRERISKGTFIMEYLGEVVTEREFKERMR 2802

  Fly  1528 ---TDDSYYF--DLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFP---KIAFFSC 1584
               .:|::::  :||.|..||.:..|:..||.||||.||.       |.|.:...   ::|.|:.
Mosquito  2803 TMYLNDTHHYCLNLDGGLVIDGHRMGSDCRFVNHSCAPNC-------EMQKWSVNGLFRMALFAM 2860

  Fly  1585 RDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCKYA----SQ--------SSSTNASPTNATT 1637
            |||...||:|:||....:......  .|||.:..|:..    ||        ||...|.....|.
Mosquito  2861 RDIPPNEELCYDYNFSLFNPSEGQ--PCRCGSEQCRGVIGGKSQRIKPIPLGSSGGGAGGPGGTG 2923

  Fly  1638 APENETGTLSSTNTEKIGHA 1657
            ...|.|...:.|:..|...|
Mosquito  2924 GQRNATEAGADTDASKAAGA 2943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	25/151 (17%)
		EHMT_ZBD	786..933	CDD:411018	28/167 (17%)
		ANKYR	1063..1322	CDD:440430	39/263 (15%)
		ANK repeat	1088..1120	CDD:293786	2/31 (6%)
		ANK repeat	1124..1153	CDD:293786	3/28 (11%)
		ANK repeat	1155..1196	CDD:293786	8/42 (19%)
		ANK repeat	1199..1249	CDD:293786	13/52 (25%)
		ANK repeat	1251..1283	CDD:293786	5/31 (16%)
		ANK repeat	1285..1316	CDD:293786	3/30 (10%)
		SET_EHMT	1391..1622	CDD:380941	67/242 (28%)
ash1	XP_061503996.1	None