Protein Alignment G9a and NSD

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_316738.6
• Gene: NSD / 1277307
• VectorBaseID: AGAMI1_000310
• Length: 1323
• Species: Anopheles gambiae
• Alignment Length: 1480
• Identity: 288/1480 - (19%)
• Similarity: 486/1480 - (32%)
• Gaps: 500/1480 - (33%)

  Fly   463 PPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPT------PKILE 521
            |...|.|:..||.:||:.               |::....:|..|..|:..|.|      .:::.
Mosquito     2 PRNTRSREVVTPEMKLQG---------------NATRKAVIQRHKSMKKNTKDTASDRSFTRLVL 51

  Fly   522 NDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDK-SDGSNFEGGPGHPA 585
            ........|||..|.:.:..:|...:.|..:|||......|..|..:|.| :......|...:.:
Mosquito    52 TSSGNNSKETKAQENLLETAAATNFETDLLSPTTTQKRVKSQESTPQSQKIAKQEPMSGSEMNES 116

  Fly   586 GTSAIKKRLFSKSQRD---IENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKK 647
            |    |:..||...|:   .||....:    ::|     .::|    ..:::::.||:..::|..
Mosquito   117 G----KENAFSDQIRNHPTDENSNTVV----RVP-----GRYL----LKQLSSSLSPKMTEINID 164

  Fly   648 QQRKLAK----QKEKH---------LKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVT 699
            ..|::::    ||:|.         :|::|...:.....|:.|..|:.|:...|      ||..:
Mosquito   165 TDRRVSRYGRHQKQKDNSDYVPVDLMKYVGSTPSKFKTKSETDDPNSVNKTLET------KPHSS 223

  Fly   700 LRVR---NSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHS 761
            ..:|   |.::..| |...|     |::..:.:.|                      |:.:||.|
Mosquito   224 DELRTGSNDISLSL-TVVPL-----PLIDGSIMKR----------------------PEEKQLLS 260

  Fly   762 LD------------------------------TSIQADVTPIRDLDMRPSTSRVSKFICLCQKPS 796
            ::                              ||..||......:|:          ..:.:..:
Mosquito   261 MEEIKIVGMEEPYYTDKGSDNNCFMNNLLERKTSSDADSGKGSSVDL----------AIIYRAGN 315

  Fly   797 QYYARNAPDSSYCCAIDHID---DQKIGCCNELSSEVHNLLRPSQRVSYM-------------IL 845
            .|:|.....|.:...|.|:|   ||......:...|||        |||.             ||
Mosquito   316 LYWAAQTRKSIHWPCIVHVDPETDQITRLYGDKFLEVH--------VSYFGDRGRRAWIKEHSIL 372

  Fly   846 ----CDEH-------------KKRLQSHNCCAGCGI---------------FCTQGKFVLCKQQH 878
                .||:             |..|:|......|.|               |..:.|..|.:.:.
Mosquito   373 PFEGVDEYCTNAKNMEYGKLLKSALKSERWKNACSIAERYMTLALSERIASFDHEVKLELARHKV 437

  Fly   879 FFHPDCAQRFILSTSYEK----------ELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTM 933
            ..|....:..|.:.:.:|          |:.:..::..:.|||           ::||
Mosquito   438 MRHRMAIEGRIKNGASQKMPALLPSDNSEVLEHWNKRDRSSSP-----------ESPE------- 484

  Fly   934 KCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAV-TLSAASSP--- 994
             .:.||....|:...||..:.:.|        ::|.    ....|:..|...: ::.:..:|
Mosquito   485 -YELLPGVFPTKNNPIKKIKFSPS--------MQNC----ILNDNRSPLDRPLHSMDSEENPPGS 536

  Fly   995 ASKTNGAQRGRAGTSNSNSRHALNSINFAQLIP---------------ESVMNVVLRG--HVVSA 1042
            |:|.||.:....|.|:..:   |||..:..::.               |..:.:.:||  ::...
Mosquito   537 ATKANGPKATTLGVSDLEN---LNSTEYDDILTFIRYYMFDGHTSYEVEKGLQLYVRGICNLKKH 598

  Fly  1043 SGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREY---LNGTCLHLV--AHSGTLQMA 1102
            |.|.|.....|...:|     |.:..|||.     :.|..|.   |.....|.|  ....||:..
Mosquito   599 SNRGTERTVGRQRMHA-----LRKSYEILG-----IEPSAEVSTSLKTRNAHPVIKKEPKTLEEK 653

  Fly  1103 YL------LLCKGASSPDFVNIVDYELRTALMCAVMNE-----KCD--MLNLFLQCGADVAIKGP 1154
            ::      .|.||...             ..:|.:.|.     ||.  .|:|.|.|.|:    .|
Mosquito   654 FIFELDKNFLMKGVPK-------------GFVCYICNRPNNVTKCSKCTLHLHLVCLAN----DP 701

  Fly  1155 DGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFID-----AQDEGGWTAMVWAAELGHTDI 1214
            :....:            |.:||..:......|..|.::     ..||        ..|..:..|
Mosquito   702 EEVVKM------------QELVDQKKLCCEKCSTTSIVEKTCFICNDE--------IPEKSNEQI 746

  Fly  1215 VR--LASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVL-HWSTLH----NDGLDTITVL 1272
            .|  :....||..:..:.:|            |.:.....:|:: .:.|.|    ::...|.:::
Mosquito   747 YRCVVGKCTQAYHISCLQLF------------PQVRQVSASTIICPYHTCHTCVASEPRSTASMV 799

  Fly  1273 LQSGADC----NVQNVEGD---------TPLHIAC-RHSVTRM------CIALIANGADLMIKNK 1317
            ..:.|.|    ...:..|:         |...:.| :|::.::      |. :...|.:|:.
Mosquito   800 KTTLAHCLKCPTSYHPSGNCIPAGSVLLTTTQLICPKHTLEQIPLNVNWCF-ICGKGGNLIC--- 860

  Fly  1318 AEQLPFDCIP-------------NEESECGRTVGFN----MQMRSFR-----------------P 1348
            .|..|..|.|             .|..|.||...:|    .:|.|||                 .
Mosquito   861 CETCPLACHPVCLQFTPPDEKYFCEGCESGRLPLYNEIVIAKMGSFRWWPALTLPPSEIPQNMLQ 925

  Fly  1349 LGLRTFVVCADASNGREARPIQVVRNELAMSENEDEAD-----SLMWPDFRY---VTQC-----I 1400
            |..:...:|....|..:...:...|..|...|:.:..|     |.|  |.||   :|:.     |
Mosquito   926 LRHKPSDICVKFFNTHDMSWLNRKRMYLYQREDSESLDGSQSGSSM--DKRYRSAMTEASKIFKI 988

  Fly  1401 IQ-------------QNSVQIDRRVSQMR---------ICSCLDSCSSDRCQCNGASSQNWYTAE 1443
            :|             ..:|.:.:::...|         :...||......|:|..:.........
Mosquito   989 LQTRKMLGPSASLSYSKAVPVYKKIKTNRYIPPLKPPSVNRQLDGVEDSVCRCQPSDDDPCGPTS 1053

  Fly  1444 SRLNADFNYEDPAVIFECND-VCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPK 1507
            :.||.       |::.||:. .|...: ||.|:.........|::....|  ||:|:.||.::..
Mosquito  1054 ACLNR-------AIMMECSSKTCPAKE-SCSNQRFTKRIYPALEVRFFSD--KGFGLVALEDLKS 1108

  Fly  1508 GTFVGSYTGEILTAMEADRRT-------DDSYYF-----DLDNGHCIDANYYGNVTRFFNHSCEP 1560
            |.||..|.||::.:.|.|||.       :.:|||     ||    .|||...|||:||.||||||
Mosquito  1109 GQFVIEYVGEVINSEEFDRRVMMMQAAKETNYYFLTVEPDL----TIDAGPKGNVSRFINHSCEP 1169

  Fly  1561 NVLPVRVFYEHQDYRFPK---IAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTC--- 1619
            |.       |.|.:...:   |..|:.:||:||||:.|:|..:......|.|:   |....|
Mosquito  1170 NC-------ETQKWTIGETRVIGLFAIKDINAGEELTFNYNLESLGNNKRVCL---CGAGKCSGF 1224

  Fly  1620 ---KY------------ASQSSSTNASP-----TNATTAPENETGTLSST 1649
               ||            .|:.|..|...     ...||..:..|..||.|
Mosquito  1225 IGEKYRPPNKKDIVISMKSERSLKNGKKRVKIRRTKTTLTQKTTRNLSET 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412
		EHMT_ZBD	786..933	CDD:411018	35/204 (17%)
		ANKYR	1063..1322	CDD:440430	52/308 (17%)
		ANK repeat	1088..1120	CDD:293786	7/39 (18%)
		ANK repeat	1124..1153	CDD:293786	9/35 (26%)
		ANK repeat	1155..1196	CDD:293786	5/45 (11%)
		ANK repeat	1199..1249	CDD:293786	7/51 (14%)
		ANK repeat	1251..1283	CDD:293786	6/40 (15%)
		ANK repeat	1285..1316	CDD:293786	7/46 (15%)
		SET_EHMT	1391..1622	CDD:380941	76/294 (26%)
NSD	XP_316738.6	None