DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and EHMT2

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_006715037.1 Gene:EHMT2 / 10919 HGNCID:14129 Length:1274 Species:Homo sapiens


Alignment Length:1440 Identity:397/1440 - (27%)
Similarity:600/1440 - (41%) Gaps:321/1440 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   336 PKRGRGRARKI----------RPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLV 390
            |.|||||.|.:          .|......:...:||..|.||..                 :::.
Human    32 PHRGRGRPRSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAP-----------------AEMG 79

  Fly   391 VVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHP-------QPSAELSFAEV 448
            .:..|:|..|..               .|:|  ||..:..::|...|       :|:...|.|.|
Human    80 ALLLEKETRGAT---------------ERVH--GSLGDTPRSEETLPKATPDSLEPAGPSSPASV 127

  Fly   449 TSEILPLAVLDE--KTPPKKRGRKAKTPCVKLESETSCG--------LPFANGNKKTNSS----G 499
            |     :.|.||  .||      ...||.:..|||...|        :...:..|...||    |
Human   128 T-----VTVGDEGADTP------VGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSKGG 181

  Fly   500 GCELQLPKRSKRRIK---PTPKILENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSN 561
            .|    |.|:|..:.   .:|..:::..:|       :..|...:.|||...:....||...|..
Human   182 SC----PSRAKMSMTGAGKSPPSVQSLAMR-------LLSMPGAQGAAAAGSEPPPATTSPEGQP 235

  Fly   562 SSTSRQKSDKSDGSNFEGGPG------------------HPAG--TSAIKKRL-------FSKSQ 599
            .....:|:....|:   |.|.                  |..|  ||.:.||.       .|:..
Human   236 KVHRARKTMSKPGN---GQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 297

  Fly   600 RDIENYGAAMLAKSKLPPCPDVEQFLNDIKA---------SRINANRSPEERKLNK---KQQRKL 652
            ......|...|.|.......:.|..:.|..:         .|::::...|...|.:   :::.:.
Human   298 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEE 362

  Fly   653 AKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLK 717
            .:::|:..:....::...||.|.|.|..:.:             |...:.:....|:.|.....:
Human   363 EEEEEEEEEEEEEEEEEEDEESGNQSDRSGS-------------SGRRKAKKKWRKDSPWVKPSR 414

  Fly   718 SRRNPVVQAAKLTRRIGARAAGEVTEAARASVPIST---PDAEQLHSLDTSIQADVTPI---RDL 776
            .||......||..|  |....|....:....||:.:   |....|......:..|.:.:   |..
Human   415 KRRKREPPRAKEPR--GVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 477

  Fly   777 DMRPSTSRVSKFICLCQKPSQYYARNAPDSSY-CCAIDHIDDQKIGCCNELSSEVHNLLRPSQRV 840
            :..|        :|.|:..:....|.:..:.: |.|.:.:|.:..||...:..  ...:|||.||
Human   478 EELP--------LCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILK--RETMRPSSRV 532

  Fly   841 SYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLC----KQQHFFHPDCAQRFILSTSYEKELGDE 901
            :.|:||:.|:.|:..|:||.|||.|||.|.|:.|    :..|.||..|..:.             
Human   533 ALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQL------------- 584

  Fly   902 EDQGVKFSSPVLVLKCPHCGLDTPE-------RTSTVTMKCQS---LPVFLRTQKYKIKPARLTT 956
              .|:.|        |||||.|..|       |...||....:   .|..|...    .|.|..|
Human   585 --NGMVF--------CPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQD----VPGRADT 635

  Fly   957 SSHLTQFGTVENANTPGATARNKGGL------STAVTLSAASSPASKTNGAQRGRAGTSNSNSRH 1015
            |.             |.|..|..|..      ..|.|:.::....:..||......|......|.
Human   636 SQ-------------PSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGRE 687

  Fly  1016 ALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTP 1080
            ||..   |.:|.||.....||.|             ||.:|.:|:..:|::|..:|..:.:....
Human   688 ALEK---ALVIQESERRKKLRFH-------------PRQLYLSVKQGELQKVILMLLDNLDPNFQ 736

  Fly  1081 IREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQC 1145
            ..:....|.||..|..|::::.::||..||:    :|.||.:.||.||.||:|...::....:|.
Human   737 SDQQSKRTPLHAAAQKGSVEICHVLLQAGAN----INAVDKQQRTPLMEAVVNNHLEVARYMVQR 797

  Fly  1146 GADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELG 1210
            |..|..|..||.|.||.||::||||...|::.:.:..         ::|||.||||.::||||..
Human   798 GGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVD---------VNAQDSGGWTPIIWAAEHK 853

  Fly  1211 HTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDN-------DNNTVLHWSTLHNDGLDT 1268
            |.:::|:                    ||.:.||..:.||       :.|..|||::.  .|...
Human   854 HIEVIRM--------------------LLTRGADVTLTDNVSERLVEEENICLHWASF--TGSAA 896

  Fly  1269 IT-VLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESE 1332
            |. |||.:..|.:..|..||||||||.|.|.....:..::.||:..::||.....:|..| |.|:
Human   897 IAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP-ERSD 960

  Fly  1333 CGRTVGFNMQMRSFRPLG-----LRT-FVVCADASNGREARPIQVVRNELAMSENEDEADSLMWP 1391
                |.|.:|:.....||     :|| .::|.|.:.|.|..||..|..          .|....|
Human   961 ----VWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNG----------VDGEPCP 1011

  Fly  1392 -DFRYVTQ-CIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYED 1454
             |::|::: |  :.:::.|||.::.::.|:|:|.|||..|.|...|.:.||..:.||..:||..:
Human  1012 EDYKYISENC--ETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIE 1074

  Fly  1455 PAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAK-GWGVRALANVPKGTFVGSYTGEI 1518
            |.:|||||..|.|.: :|||||||:|.:..||:..   .|| |||||||..:|:|||:..|.||:
Human  1075 PPLIFECNQACSCWR-NCKNRVVQSGIKVRLQLYR---TAKMGWGVRALQTIPQGTFICEYVGEL 1135

  Fly  1519 LTAMEADRRTDDSYYFDLDNG----HCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKI 1579
            ::..|||.|.||||.|||||.    :||||.||||::||.||.|:||::|||||..|||.|||:|
Human  1136 ISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRI 1200

  Fly  1580 AFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCKYASQSSSTNASP-TNATTAPE--N 1641
            ||||.|||..|||:.||||::||.::.:... |:|.:..||:::::.:...|. ......||  .
Human  1201 AFFSSRDIRTGEELGFDYGDRFWDIKSKYFT-CQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1264

  Fly  1642 ETGTLSSTNT 1651
            |.|:|...||
Human  1265 ELGSLPPVNT 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375
Ank_2 1056..1152 CDD:289560 27/95 (28%)
ANK 1088..1217 CDD:238125 47/128 (37%)
ANK repeat 1088..1120 CDD:293786 10/31 (32%)
ANK repeat 1124..1153 CDD:293786 10/28 (36%)
Ank_2 1127..1249 CDD:289560 38/121 (31%)
ANK 1155..1306 CDD:238125 52/158 (33%)
ANK repeat 1155..1196 CDD:293786 13/40 (33%)
ANK repeat 1199..1249 CDD:293786 13/49 (27%)
Ank_2 1205..1316 CDD:289560 35/118 (30%)
ANK repeat 1251..1283 CDD:293786 10/32 (31%)
ANK repeat 1285..1316 CDD:293786 12/30 (40%)
PreSET 1357..1466 CDD:128744 36/110 (33%)
SET 1495..1602 CDD:214614 69/111 (62%)
EHMT2XP_006715037.1 cond_enzymes <46..>139 CDD:299129 23/131 (18%)
Ank_2 711..798 CDD:289560 25/90 (28%)
ANK <711..762 CDD:295348 10/50 (20%)
ANK 743..862 CDD:238125 48/151 (32%)
ANK repeat 743..772 CDD:293786 10/32 (31%)
Ank_2 779..872 CDD:289560 38/121 (31%)
ANK 806..935 CDD:238125 52/159 (33%)
ANK repeat 807..839 CDD:293786 13/40 (33%)
ANK repeat 841..872 CDD:293786 14/50 (28%)
ANK repeat 881..912 CDD:293786 10/32 (31%)
Ank_5 901..954 CDD:290568 18/52 (35%)
ANK repeat 914..945 CDD:293786 12/30 (40%)
PreSET 987..1086 CDD:128744 36/110 (33%)
SET 1102..1224 CDD:214614 73/124 (59%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157958
Domainoid 1 1.000 151 1.000 Domainoid score I4352
eggNOG 1 0.900 - - E2759_KOG1082
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 436 1.000 Inparanoid score I1700
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D753093at2759
OrthoFinder 1 1.000 - - FOG0003434
OrthoInspector 1 1.000 - - otm41476
orthoMCL 1 0.900 - - OOG6_105922
Panther 1 1.100 - - LDO PTHR46307
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R211
SonicParanoid 1 1.000 - - X1720
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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