Protein Alignment G9a and Kmt2b

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: NP_001414070.1
• Gene: Kmt2b / 102550344
• RGDID: 7678027
• Length: 2714
• Species: Rattus norvegicus
• Alignment Length: 1133
• Identity: 216/1133 - (19%)
• Similarity: 364/1133 - (32%)
• Gaps: 385/1133 - (33%)

  Fly    49 QFASKEKK----------------------------HKDKEEEERKEARNQEEIEDIKALLADVV 85
            :|.||.||                            .:|.:|:||...|.::|
  Rat   306 KFVSKAKKVKMGQLSQGLESGQGRGQRGESWQDAPQRRDGDEQERGPCRKKQE------------ 358

  Fly    86 DAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDSEM---EKKQNGKATS--ITV 145
                .|||||..:..||.:     :.|:..:::.|.|.:.|..:.|:   ::|:..|..|  :|.
  Rat   359 ----QKLEEEGEEKGEKED-----DSEDNSKQQEEEDTERAVAEEEVMLAKEKEEAKLPSPPLTP 414

  Fly   146 KMES-----------------------------------NERAEKHATEI-ATTSTERWENESFK 174
            .:.|                                   .|:.|:....: ||.|.:|.......
  Rat   415 PVPSPPPPLPPPSTSPPPASPLPPPVSPPPPPSPPPYPAPEKQEESPPLVPATCSRKRGRPPLTP 479

  Fly   175 TEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATS 239
            :::..::||....|..|:.|      |.|.:||...|. .||.||..::..|
  Rat   480 SQRAEREAARSGPEGTLSPT------ANPSSTTGSPVE-DSPTVVPKSTTFL------------- 524

  Fly   240 AGAATLADKNVQ--VSPGGTRRSRR---TPR--------------------PIDTPTSVTDEHVQ 279
                    ||::  :.|..:.||.|   |||                    |:.|......|.|.
  Rat   525 --------KNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEASIVRPPVATSPLAPQEPVP 581

  Fly   280 VENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSE-PDKPSLTALSPEENSAPAPKRGRG-- 341
            |.:.....:...|......:|.::..........|..| |..|.....:|....|||....|.
  Rat   582 VSSPPRVPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPAPSPPPAPATPSRRPLL 646

  Fly   342 -RARKIRP-DAEVETSEVIL----------------PCEDSLGEKKP---GRKRKLPDEPIDQQQ 385
             ||.:..| :|.::..|.:|                |.:||..|.:|   ||...|        .
  Rat   647 LRAPQFTPSEAHLKIYESVLTPPPLGALEAPEPELPPADDSPAEPEPRAVGRTNHL--------S 703

  Fly   386 LSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEAL-----------HPQP 439
            |...|.|.|...::...|.|     ..::..|.:|.....| :.::|:.|           .|.|
  Rat   704 LPRFVPVVTTPVKVEMPPHG-----APALSEGQQLQLQQPP-QALQTQLLPQALPPQQPQMQPPP 762

  Fly   440 SAE----LSFAEVTS-EILPLAVLDEK--------------------------TPPKKR------ 467
            |.:    |....|.| ..|||:.::||                          .||...
  Rat   763 SPQHTPPLEKTRVASLGPLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPPSPAVQTEEA 827

  Fly   468 -GRKAKTP---CVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPT--PKILENDELR 526
             |...:||   ||:.|.|:.        ..|.:.:.|.|           .|.  |:|
  Rat   828 VGTVKQTPDRGCVRSEDESM--------EAKRDGASGPE-----------SPVQGPRI------- 866

  Fly   527 CEFETKHIER---MTQWESAAAVDGDF---------------ETPTTGGNGSNSSTSRQKSDKSD 573
                 ||:.|   :...::.|.|..|.               ...|:..:.:.|..||.:.:|.:
  Rat   867 -----KHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVE 926

  Fly   574 GSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPC------PDVEQFLNDIKASR 632
            .:. .||...|.|::.   .|....:|.:.::....:..::...|      .|....:|.:...:
  Rat   927 SAG-PGGDSEPTGSAG---ALAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPK 987

  Fly   633 INANRSPEE----RKLNKKQQRK---LAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTR 690
            .....:.::    ||.:|.:.||   |||:....:|.|        .|.|:|.|...:...|..|
  Rat   988 FGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTL--------LPWDSDESPEASPGPPGPR 1044

  Fly   691 VQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVP----- 750
            ...|        .....:|:..|...:.:.:.::|.....|.:..|.:.:|.|.:..|.|
  Rat  1045 RGAG--------AGGPREEVGATPGPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPA 1101

  Fly   751 --ISTPDAEQLHSLDTSIQA-----DVTPIRDLDMRPSTSRVSKFICLCQKPSQYY------ARN 802
              ..||...:|..|:...|:     .:.|:..|..|   .|:.| ..|...|...:      .:.
  Rat  1102 PRRRTPREHELPMLEPEEQSRPRKPTLQPVLQLKAR---RRLDK-DALAPGPFASFPNGWTGKQK 1162

  Fly   803 APDSSYCCAIDHIDDQKI------GCCNELSS-----EVHNLLRPSQRVSYMILC---------- 846
            :||..:...:|..:|..:      |..:.|:|     .:..||..|:.:..::.|
  Rat  1163 SPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPF 1227

  Fly   847 --DEHKKRLQSHN---CCAGCGIFC----TQGK----FVLCKQ-QHFFHPDCAQRFILSTSYEKE 897
              :|.::.|..|.   ||..|. ||    .:|:    .:.|:: :|.:||.|     |..||...
  Rat  1228 CLEEAERPLPQHRDTWCCRRCK-FCHVCGRKGRGSKHLLECERCRHAYHPAC-----LGPSYPTR 1286

  Fly   898 LGDEEDQGVKFSSPVLVLKCPHCGLDTP 925
            ........:..:    .::|..||. ||
  Rat  1287 ATRRRRHWICSA----CVRCKSCGA-TP 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	27/160 (17%)
		EHMT_ZBD	786..933	CDD:411018	36/181 (20%)
		ANKYR	1063..1322	CDD:440430
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		SET_EHMT	1391..1622	CDD:380941
Kmt2b	NP_001414070.1	zf-CXXC	956..1003	CDD:366873	4/46 (9%)
		PHD1_KMT2B	1202..1248	CDD:277064	9/45 (20%)
		PHD2_KMT2B	1250..1299	CDD:277066	11/57 (19%)
		PHD3_KMT2B	1336..1392	CDD:277068
		Bromo_ALL-1	1373..1515	CDD:99925
		ePHD_KMT2B	1580..1684	CDD:277164
		FYRN	1732..1779	CDD:461787
		PHA03247	<1807..2315	CDD:223021
		FYRC	2412..2496	CDD:197781
		SET_KMT2A_2B	2561..2714	CDD:380947