DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Kmt2b

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_038949797.1	Gene:	Kmt2b / 102550344	RGDID:	7678027	Length:	2714	Species:	Rattus norvegicus

Alignment Length:	1133	Identity:	216/1133 - (19%)
Similarity:	364/1133 - (32%)	Gaps:	385/1133 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QFASKEKK----------------------------HKDKEEEERKEARNQEEIEDIKALLADVV 85
            :|.||.||                            .:|.:|:||...|.::|
  Rat   306 KFVSKAKKVKMGQLSQGLESGQGRGQRGESWQDAPQRRDGDEQERGPCRKKQE------------ 358

  Fly    86 DAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDSEM---EKKQNGKATS--ITV 145
                .|||||..:..||.:     :.|:..:::.|.|.:.|..:.|:   ::|:..|..|  :|.
  Rat   359 ----QKLEEEGEEKGEKED-----DSEDNSKQQEEEDTERAVAEEEVMLAKEKEEAKLPSPPLTP 414

  Fly   146 KMES-----------------------------------NERAEKHATEI-ATTSTERWENESFK 174
            .:.|                                   .|:.|:....: ||.|.:|.......
  Rat   415 PVPSPPPPLPPPSTSPPPASPLPPPVSPPPPPSPPPYPAPEKQEESPPLVPATCSRKRGRPPLTP 479

  Fly   175 TEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATS 239
            :::..::||....|..|:.|      |.|.:||...|. .||.||..::..|
  Rat   480 SQRAEREAARSGPEGTLSPT------ANPSSTTGSPVE-DSPTVVPKSTTFL------------- 524

  Fly   240 AGAATLADKNVQ--VSPGGTRRSRR---TPR--------------------PIDTPTSVTDEHVQ 279
                    ||::  :.|..:.||.|   |||                    |:.|......|.|.
  Rat   525 --------KNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEASIVRPPVATSPLAPQEPVP 581

  Fly   280 VENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSE-PDKPSLTALSPEENSAPAPKRGRG-- 341
            |.:.....:...|......:|.::..........|..| |..|.....:|....|||....|.
  Rat   582 VSSPPRVPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPAPSPPPAPATPSRRPLL 646

  Fly   342 -RARKIRP-DAEVETSEVIL----------------PCEDSLGEKKP---GRKRKLPDEPIDQQQ 385
             ||.:..| :|.::..|.:|                |.:||..|.:|   ||...|        .
  Rat   647 LRAPQFTPSEAHLKIYESVLTPPPLGALEAPEPELPPADDSPAEPEPRAVGRTNHL--------S 703

  Fly   386 LSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEAL-----------HPQP 439
            |...|.|.|...::...|.|     ..::..|.:|.....| :.::|:.|           .|.|
  Rat   704 LPRFVPVVTTPVKVEMPPHG-----APALSEGQQLQLQQPP-QALQTQLLPQALPPQQPQMQPPP 762

  Fly   440 SAE----LSFAEVTS-EILPLAVLDEK--------------------------TPPKKR------ 467
            |.:    |....|.| ..|||:.::||                          .||...
  Rat   763 SPQHTPPLEKTRVASLGPLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPPSPAVQTEEA 827

  Fly   468 -GRKAKTP---CVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPT--PKILENDELR 526
             |...:||   ||:.|.|:.        ..|.:.:.|.|           .|.  |:|
  Rat   828 VGTVKQTPDRGCVRSEDESM--------EAKRDGASGPE-----------SPVQGPRI------- 866

  Fly   527 CEFETKHIER---MTQWESAAAVDGDF---------------ETPTTGGNGSNSSTSRQKSDKSD 573
                 ||:.|   :...::.|.|..|.               ...|:..:.:.|..||.:.:|.:
  Rat   867 -----KHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVE 926

  Fly   574 GSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPC------PDVEQFLNDIKASR 632
            .:. .||...|.|::.   .|....:|.:.::....:..::...|      .|....:|.:...:
  Rat   927 SAG-PGGDSEPTGSAG---ALAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPK 987

  Fly   633 INANRSPEE----RKLNKKQQRK---LAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTR 690
            .....:.::    ||.:|.:.||   |||:....:|.|        .|.|:|.|...:...|..|
  Rat   988 FGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTL--------LPWDSDESPEASPGPPGPR 1044

  Fly   691 VQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVP----- 750
            ...|        .....:|:..|...:.:.:.::|.....|.:..|.:.:|.|.:..|.|
  Rat  1045 RGAG--------AGGPREEVGATPGPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPA 1101

  Fly   751 --ISTPDAEQLHSLDTSIQA-----DVTPIRDLDMRPSTSRVSKFICLCQKPSQYY------ARN 802
              ..||...:|..|:...|:     .:.|:..|..|   .|:.| ..|...|...:      .:.
  Rat  1102 PRRRTPREHELPMLEPEEQSRPRKPTLQPVLQLKAR---RRLDK-DALAPGPFASFPNGWTGKQK 1162

  Fly   803 APDSSYCCAIDHIDDQKI------GCCNELSS-----EVHNLLRPSQRVSYMILC---------- 846
            :||..:...:|..:|..:      |..:.|:|     .:..||..|:.:..::.|
  Rat  1163 SPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPF 1227

  Fly   847 --DEHKKRLQSHN---CCAGCGIFC----TQGK----FVLCKQ-QHFFHPDCAQRFILSTSYEKE 897
              :|.::.|..|.   ||..|. ||    .:|:    .:.|:: :|.:||.|     |..||...
  Rat  1228 CLEEAERPLPQHRDTWCCRRCK-FCHVCGRKGRGSKHLLECERCRHAYHPAC-----LGPSYPTR 1286

  Fly   898 LGDEEDQGVKFSSPVLVLKCPHCGLDTP 925
            ........:..:    .::|..||. ||
  Rat  1287 ATRRRRHWICSA----CVRCKSCGA-TP 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	21/98 (21%)
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744
		SET	1495..1602	CDD:214614
Kmt2b	XP_038949797.1	zf-CXXC	956..1003	CDD:366873	4/46 (9%)
		PHD1_KMT2B	1202..1248	CDD:277064	9/45 (20%)
		PHD2_KMT2B	1250..1299	CDD:277066	11/57 (19%)
		PHD3_KMT2B	1336..1392	CDD:277068
		Bromo_ALL-1	1373..1515	CDD:99925
		ePHD_KMT2B	1580..1684	CDD:277164
		FYRN	1732..1779	CDD:399155
		PHA03247	<1807..2315	CDD:223021
		FYRC	2412..2496	CDD:197781
		SET_KMT2A_2B	2561..2714	CDD:380947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930