Protein Alignment G9a and kmt2d

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_009295228.1
• Gene: kmt2d / 100536523
• ZFINID: ZDB-GENE-060223-2
• Length: 4967
• Species: Danio rerio
• Alignment Length: 1697
• Identity: 312/1697 - (18%)
• Similarity: 512/1697 - (30%)
• Gaps: 598/1697 - (35%)

  Fly   144 TVKMESNERAEKHATEIATTSTERWENESF-KTEQQNKKAAEKEEEPILAATQKLEANAEPLTTT 207
            |..:...:.:..||...|.:|.....:.|. |.|..|...:.....|  :..:.:...:.|.:.|
Zfish  3645 TTALSPFQASPSHAGSPAGSSVPEAGSPSLNKPEPGNMALSSNLSSP--SRPEGIVGKSSPFSQT 3707

  Fly   208 --RIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGT------------- 257
              .|...:.||...:.:....|..|...:...:|..|...|..:.|:|.|.|
Zfish  3708 GGLIPSPLRSPTAKTQSPNTEALSAPFPLNGPSSQVAQNQAPNSGQISGGHTSQPTQMPSEMCKM 3772

  Fly   258 --RRSRRTPRPIDTPT-------------SVTDEHVQ---VENKKFGKSEQYTDCSSHLERFT-- 302
              :..::.||.:...|             .::.|.|.   :.|...|...|..|..|.::|..
Zfish  3773 TLQNIKQEPREVQCDTGNIVETHSDGIKREISGESVSGSGIVNSAVGSRNQAGDIGSQIQRTETG 3837

  Fly   303 -------------------------------LDDNTAIVRLQLKSEP----DKPSLTALSP---E 329
                                           :::..|::..:|:..|    |..|||..:|   .
Zfish  3838 QQLLQKLLRTKNLQVAAQRPSDGIHNEINGHINNKLAMLEQKLQGTPRNMEDLQSLTKRAPIVKA 3902

  Fly   330 ENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKT 394
            :.:|.|.:||....:|.:.: ||..:|.|:.      :.|.|.......||.....| ||..
Zfish  3903 KRTAKAGERGPNSRKKTKKE-EVGKTEAIMK------QLKQGLSLLPLMEPSITASL-DLFA--- 3956

  Fly   395 EQEELGDAPLGDVKRMRRSVRLGNRLHADGSP--WEEVKTE---ALHPQPSAELSFAEVTSEILP 454
               ..|.:|.....:::.|  .||.: .|..|  :.::.|:   :..|.|.:.|
Zfish  3957 ---PFGSSPANAKTQLKGS--FGNAI-LDNIPDYYSQLLTKNNLSNPPTPPSSL----------- 4004

  Fly   455 LAVLDEKTPPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKR----RIKP 515
                 ..|||.....|......::|.       .|.|.|:|.:|......:|:..|.    ...|
Zfish  4005 -----PPTPPPSVQHKLLNGVTQVEE-------LAEGQKETEASEDTIGSVPEEVKSVDILAALP 4057

  Fly   516 TPKILENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDK--------- 571
            ||...:|:::|.|.:.         :|.|:   |...|.       ||...|..|:
Zfish  4058 TPPHNQNEDIRMESDD---------DSDAS---DSIVPA-------SSPESQLGDETTRFPSLLD 4103

  Fly   572 -------------------------SDGSNFEGGPGHPAGTSAIKKR--------LFSKSQRDIE 603
                                     |:...||...|....:|:...:        .|..|....:
Zfish  4104 PKEEEEERAISPVIPIIPRSTIPNFSETKPFESVDGKVVASSSQWDKAKSNEVSVTFMLSSAAAK 4168

  Fly   604 NYGAAMLAKSKL-------------PPCPDVEQFLNDIKASRINA--NRSPEERKLNKKQQRKLA 653
            |....|||.::|             |..|           .|:.|  .:.|:......|....::
Zfish  4169 NLNTVMLAVAQLLHIRMPSSYELAFPQSP-----------GRVGAGPGKVPDSSNPGLKTDASVS 4222

  Fly   654 KQKE---------------KHLKHLGLQKNHRDEPSDNDS--------SNTDNEFFPTTRVQVG- 694
            ...|               |.:..|.|.|....|..|..:        |:.|....|...|:|.
Zfish  4223 NDAEWLKQFDVSLPGCTLRKQVDILALIKQESQEQEDKPAQHCYMTNVSDLDVRHLPVIPVEVSP 4287

  Fly   695 --------KPSVTLRVRNSVTKELP---TTATLKSRRNPVVQ-AAKLTRRIGARAAG-------E 740
                    .||.|:....:.|:..|   :.||:::..:|... :|.:...|..:...       |
Zfish  4288 PPSPSPPPPPSSTVAEPENTTQPEPKPESEATVQTTSSPSASPSAPVKTEILVKQESHCSPVTVE 4352

  Fly   741 VTEAARASVPISTPDAEQLHS-------LDT--------SIQADVTPIRDLDMRPSTSRVSKFIC 790
            ......|.:||:.|..::..|       ||:        ||:....|:.|.:.||   :|.|:..
Zfish  4353 PESHEPAVLPIAVPPPQEQPSAPASSPPLDSPTIEISLKSIKHRSRPLSDEEQRP---KVKKWKG 4414

  Fly   791 LCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQS 855
            |..|..|..               |..:|.|...|.|.||..|:   :|:...:..|  |.....
Zfish  4415 LRWKRLQIV---------------ITIRKGGSKKESSREVSELM---ERLRITLKPD--KLPRDK 4459

  Fly   856 HNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHC 920
            ..||     ||                                 .||..|
Zfish  4460 RKCC-----FC---------------------------------HEEGDG--------------- 4471

  Fly   921 GLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTA 985
            ..|.|.|...:.:   .|.|.|..       |..:|..:.||.|.:.|..    .|..:|
Zfish  4472 ATDGPARLLNIDV---DLWVHLNC-------ALWSTEVYETQGGALINVE----VALRRG----- 4517

  Fly   986 VTLSAASSPASKTNGAQRGRAGTSNS-NSRHALNSINFAQLIPESVM-----NVVLRGHVVSA-S 1043
                      .:|..|...:.|.:|| |.....|..:||..|....|     .::...|.:.. |
Zfish  4518 ----------LRTRCAYCQKTGATNSCNRLRCPNVYHFACAIRARCMFFKDKTMLCTQHKLKGPS 4572

  Fly  1044 GRVTAEFTP-RDMYYAVQNDDLERVAEILAAD-----FNVLTPIREYLNGTCLHLVAHSGTLQMA 1102
            ....:.|.. |.:|  ::.|:::::|.||...     |.|        .|...|.|......|||
Zfish  4573 EEELSSFAVFRRVY--IERDEVKQIASILQRGDRIHLFRV--------GGLIFHAVGQLLPSQMA 4627

  Fly  1103 YLLLCKGASSPDFVNIVDYE-LRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQL 1166
            ..      .||..:..|.|| .|......|.|.:|.     .:|    .|...||:....:
Zfish  4628 VF------HSPSAIYPVGYEATRIYWSTRVPNRRCR-----YRC----RISEQDGRPLFEV---- 4673

  Fly  1167 GNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASL-PQAVFLKLIN 1230
                  :::...|..       |.|.|:..:|.|      |::.|    ::|.| .:|..|||.
Zfish  4674 ------RVLEHGYED-------LHFRDSTPDGIW------AKIVH----QVAKLRDEAAMLKLF- 4714

  Fly  1231 IFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACR 1295
                                                              .::|.|:....:..
Zfish  4715 --------------------------------------------------TEHVRGEEMYGLTV- 4728

  Fly  1296 HSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADA 1360
            |:|.|:.                     :.:|..||                         |.|.
Zfish  4729 HAVMRIT---------------------ESLPGVES-------------------------CQDY 4747

  Fly  1361 SNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCS 1425
            :......|:.    ||.:..|.              |.|...:..:     ::..:....|:|.|
Zfish  4748 TFRYGRHPLM----ELPLMINP--------------TGCARSEPKI-----LTHCKRPHTLNSTS 4789

  Fly  1426 SDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVEC 1490
            ..:      :.|:.:|.|  :|..::.:            ..:..|.:.|.::...:|.:.:  .
Zfish  4790 MSK------AYQSTFTGE--INTPYSKQ------------FVHSKSSQYRRLKTEWKTNVYL--A 4832

  Fly  1491 EDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDSYYFDLDNGHCIDANYYG 1548
            ..:.:|.|:.|..::.|.|.|..|.|.|:....|:||       ....|.|.::|.|.|||...|
Zfish  4833 RSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTG 4897

  Fly  1549 NVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCR 1613
            ...|:.||||.||.:...|.::.:|    ||...|.|.|..|||:.:||...|...:|:  :.|.
Zfish  4898 GPARYVNHSCAPNCVAEVVTFDKED----KIIIISSRRIPKGEELTYDYQFDFEDDQHK--IPCH 4956

  Fly  1614 CLTTTCK 1620
            |....|:
Zfish  4957 CGAWNCR 4963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	9/44 (20%)
		EHMT_ZBD	786..933	CDD:411018	25/146 (17%)
		ANKYR	1063..1322	CDD:440430	43/265 (16%)
		ANK repeat	1088..1120	CDD:293786	7/31 (23%)
		ANK repeat	1124..1153	CDD:293786	6/28 (21%)
		ANK repeat	1155..1196	CDD:293786	6/40 (15%)
		ANK repeat	1199..1249	CDD:293786	9/50 (18%)
		ANK repeat	1251..1283	CDD:293786	0/31 (0%)
		ANK repeat	1285..1316	CDD:293786	4/30 (13%)
		SET_EHMT	1391..1622	CDD:380941	56/237 (24%)
kmt2d	XP_009295228.1	PHD_SF	122..205	CDD:473978
		PHD1_KMT2C_like	218..263	CDD:276984
		PHD_SF	265..310	CDD:473978
		PHD	346..391	CDD:214584
		DUF612	<401..>613	CDD:282585
		PHD_SF	821..871	CDD:473978
		PHD5_KMT2C_like	872..918	CDD:276988
		PHD5_KMT2D	949..999	CDD:277074
		HMG-box_KMT2D	1447..1530	CDD:438836
		PHA03247	<1559..1927	CDD:223021
		PHA03247	<1750..2209	CDD:223021
		Med15	2957..>3361	CDD:312941
		Med15	3286..>3690	CDD:312941	9/44 (20%)
		PHD_SF	4462..4568	CDD:473978	33/187 (18%)
		FYRN	4611..4662	CDD:461787	16/65 (25%)
		FYRC	4668..4752	CDD:461788	24/208 (12%)
		SET_KMT2C_2D	4814..4966	CDD:380948	47/158 (30%)