DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and kmt2d

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_009295228.1	Gene:	kmt2d / 100536523	ZFINID:	ZDB-GENE-060223-2	Length:	4967	Species:	Danio rerio

Alignment Length:	1697	Identity:	312/1697 - (18%)
Similarity:	512/1697 - (30%)	Gaps:	598/1697 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 TVKMESNERAEKHATEIATTSTERWENESF-KTEQQNKKAAEKEEEPILAATQKLEANAEPLTTT 207
            |..:...:.:..||...|.:|.....:.|. |.|..|...:.....|  :..:.:...:.|.:.|
Zfish  3645 TTALSPFQASPSHAGSPAGSSVPEAGSPSLNKPEPGNMALSSNLSSP--SRPEGIVGKSSPFSQT 3707

  Fly   208 --RIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGT------------- 257
              .|...:.||...:.:....|..|...:...:|..|...|..:.|:|.|.|
Zfish  3708 GGLIPSPLRSPTAKTQSPNTEALSAPFPLNGPSSQVAQNQAPNSGQISGGHTSQPTQMPSEMCKM 3772

  Fly   258 --RRSRRTPRPIDTPT-------------SVTDEHVQ---VENKKFGKSEQYTDCSSHLERFT-- 302
              :..::.||.:...|             .::.|.|.   :.|...|...|..|..|.::|..
Zfish  3773 TLQNIKQEPREVQCDTGNIVETHSDGIKREISGESVSGSGIVNSAVGSRNQAGDIGSQIQRTETG 3837

  Fly   303 -------------------------------LDDNTAIVRLQLKSEP----DKPSLTALSP---E 329
                                           :::..|::..:|:..|    |..|||..:|   .
Zfish  3838 QQLLQKLLRTKNLQVAAQRPSDGIHNEINGHINNKLAMLEQKLQGTPRNMEDLQSLTKRAPIVKA 3902

  Fly   330 ENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKT 394
            :.:|.|.:||....:|.:.: ||..:|.|:.      :.|.|.......||.....| ||..
Zfish  3903 KRTAKAGERGPNSRKKTKKE-EVGKTEAIMK------QLKQGLSLLPLMEPSITASL-DLFA--- 3956

  Fly   395 EQEELGDAPLGDVKRMRRSVRLGNRLHADGSP--WEEVKTE---ALHPQPSAELSFAEVTSEILP 454
               ..|.:|.....:::.|  .||.: .|..|  :.::.|:   :..|.|.:.|
Zfish  3957 ---PFGSSPANAKTQLKGS--FGNAI-LDNIPDYYSQLLTKNNLSNPPTPPSSL----------- 4004

  Fly   455 LAVLDEKTPPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKR----RIKP 515
                 ..|||.....|......::|.       .|.|.|:|.:|......:|:..|.    ...|
Zfish  4005 -----PPTPPPSVQHKLLNGVTQVEE-------LAEGQKETEASEDTIGSVPEEVKSVDILAALP 4057

  Fly   516 TPKILENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDK--------- 571
            ||...:|:::|.|.:.         :|.|:   |...|.       ||...|..|:
Zfish  4058 TPPHNQNEDIRMESDD---------DSDAS---DSIVPA-------SSPESQLGDETTRFPSLLD 4103

  Fly   572 -------------------------SDGSNFEGGPGHPAGTSAIKKR--------LFSKSQRDIE 603
                                     |:...||...|....:|:...:        .|..|....:
Zfish  4104 PKEEEEERAISPVIPIIPRSTIPNFSETKPFESVDGKVVASSSQWDKAKSNEVSVTFMLSSAAAK 4168

  Fly   604 NYGAAMLAKSKL-------------PPCPDVEQFLNDIKASRINA--NRSPEERKLNKKQQRKLA 653
            |....|||.::|             |..|           .|:.|  .:.|:......|....::
Zfish  4169 NLNTVMLAVAQLLHIRMPSSYELAFPQSP-----------GRVGAGPGKVPDSSNPGLKTDASVS 4222

  Fly   654 KQKE---------------KHLKHLGLQKNHRDEPSDNDS--------SNTDNEFFPTTRVQVG- 694
            ...|               |.:..|.|.|....|..|..:        |:.|....|...|:|.
Zfish  4223 NDAEWLKQFDVSLPGCTLRKQVDILALIKQESQEQEDKPAQHCYMTNVSDLDVRHLPVIPVEVSP 4287

  Fly   695 --------KPSVTLRVRNSVTKELP---TTATLKSRRNPVVQ-AAKLTRRIGARAAG-------E 740
                    .||.|:....:.|:..|   :.||:::..:|... :|.:...|..:...       |
Zfish  4288 PPSPSPPPPPSSTVAEPENTTQPEPKPESEATVQTTSSPSASPSAPVKTEILVKQESHCSPVTVE 4352

  Fly   741 VTEAARASVPISTPDAEQLHS-------LDT--------SIQADVTPIRDLDMRPSTSRVSKFIC 790
            ......|.:||:.|..::..|       ||:        ||:....|:.|.:.||   :|.|:..
Zfish  4353 PESHEPAVLPIAVPPPQEQPSAPASSPPLDSPTIEISLKSIKHRSRPLSDEEQRP---KVKKWKG 4414

  Fly   791 LCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQS 855
            |..|..|..               |..:|.|...|.|.||..|:   :|:...:..|  |.....
Zfish  4415 LRWKRLQIV---------------ITIRKGGSKKESSREVSELM---ERLRITLKPD--KLPRDK 4459

  Fly   856 HNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHC 920
            ..||     ||                                 .||..|
Zfish  4460 RKCC-----FC---------------------------------HEEGDG--------------- 4471

  Fly   921 GLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTA 985
            ..|.|.|...:.:   .|.|.|..       |..:|..:.||.|.:.|..    .|..:|
Zfish  4472 ATDGPARLLNIDV---DLWVHLNC-------ALWSTEVYETQGGALINVE----VALRRG----- 4517

  Fly   986 VTLSAASSPASKTNGAQRGRAGTSNS-NSRHALNSINFAQLIPESVM-----NVVLRGHVVSA-S 1043
                      .:|..|...:.|.:|| |.....|..:||..|....|     .::...|.:.. |
Zfish  4518 ----------LRTRCAYCQKTGATNSCNRLRCPNVYHFACAIRARCMFFKDKTMLCTQHKLKGPS 4572

  Fly  1044 GRVTAEFTP-RDMYYAVQNDDLERVAEILAAD-----FNVLTPIREYLNGTCLHLVAHSGTLQMA 1102
            ....:.|.. |.:|  ::.|:::::|.||...     |.|        .|...|.|......|||
Zfish  4573 EEELSSFAVFRRVY--IERDEVKQIASILQRGDRIHLFRV--------GGLIFHAVGQLLPSQMA 4627

  Fly  1103 YLLLCKGASSPDFVNIVDYE-LRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQL 1166
            ..      .||..:..|.|| .|......|.|.:|.     .:|    .|...||:....:
Zfish  4628 VF------HSPSAIYPVGYEATRIYWSTRVPNRRCR-----YRC----RISEQDGRPLFEV---- 4673

  Fly  1167 GNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASL-PQAVFLKLIN 1230
                  :::...|..       |.|.|:..:|.|      |::.|    ::|.| .:|..|||.
Zfish  4674 ------RVLEHGYED-------LHFRDSTPDGIW------AKIVH----QVAKLRDEAAMLKLF- 4714

  Fly  1231 IFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACR 1295
                                                              .::|.|:....:..
Zfish  4715 --------------------------------------------------TEHVRGEEMYGLTV- 4728

  Fly  1296 HSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADA 1360
            |:|.|:.                     :.:|..||                         |.|.
Zfish  4729 HAVMRIT---------------------ESLPGVES-------------------------CQDY 4747

  Fly  1361 SNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCS 1425
            :......|:.    ||.:..|.              |.|...:..:     ::..:....|:|.|
Zfish  4748 TFRYGRHPLM----ELPLMINP--------------TGCARSEPKI-----LTHCKRPHTLNSTS 4789

  Fly  1426 SDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVEC 1490
            ..:      :.|:.:|.|  :|..::.:            ..:..|.:.|.::...:|.:.:  .
Zfish  4790 MSK------AYQSTFTGE--INTPYSKQ------------FVHSKSSQYRRLKTEWKTNVYL--A 4832

  Fly  1491 EDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDSYYFDLDNGHCIDANYYG 1548
            ..:.:|.|:.|..::.|.|.|..|.|.|:....|:||       ....|.|.::|.|.|||...|
Zfish  4833 RSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTG 4897

  Fly  1549 NVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCR 1613
            ...|:.||||.||.:...|.::.:|    ||...|.|.|..|||:.:||...|...:|:  :.|.
Zfish  4898 GPARYVNHSCAPNCVAEVVTFDKED----KIIIISSRRIPKGEELTYDYQFDFEDDQHK--IPCH 4956

  Fly  1614 CLTTTCK 1620
            |....|:
Zfish  4957 CGAWNCR 4963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	19/100 (19%)
		Ank_2	1056..1152	CDD:289560	23/101 (23%)
		ANK	1088..1217	CDD:238125	26/129 (20%)
		ANK repeat	1088..1120	CDD:293786	7/31 (23%)
		ANK repeat	1124..1153	CDD:293786	6/28 (21%)
		Ank_2	1127..1249	CDD:289560	21/122 (17%)
		ANK	1155..1306	CDD:238125	21/151 (14%)
		ANK repeat	1155..1196	CDD:293786	6/40 (15%)
		ANK repeat	1199..1249	CDD:293786	9/50 (18%)
		Ank_2	1205..1316	CDD:289560	13/111 (12%)
		ANK repeat	1251..1283	CDD:293786	0/31 (0%)
		ANK repeat	1285..1316	CDD:293786	4/30 (13%)
		PreSET	1357..1466	CDD:128744	15/108 (14%)
		SET	1495..1602	CDD:214614	39/113 (35%)
kmt2d	XP_009295228.1	PHD_SF	122..205	CDD:304600
		PHD1_KMT2C_like	218..263	CDD:276984
		PHD_SF	265..310	CDD:304600
		PHD	346..391	CDD:214584
		PHD_SF	821..871	CDD:304600
		PHD5_KMT2C_like	872..918	CDD:276988
		PHD5_KMT2D	949..999	CDD:277074
		HMG	1473..1528	CDD:197700
		Med15	3305..>3717	CDD:255446	13/73 (18%)
		PHD_SF	4462..4568	CDD:304600	33/187 (18%)
		FYRN	4612..4662	CDD:283589	16/64 (25%)
		FYRC	4668..4749	CDD:283590	24/205 (12%)
		SET	4828..4949	CDD:214614	40/126 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000