Protein Alignment G9a and Kmt2d

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_063118908.1
• Gene: Kmt2d / 100362634
• RGDID: 2324324
• Length: 5565
• Species: Rattus norvegicus
• Alignment Length: 1699
• Identity: 312/1699 - (18%)
• Similarity: 506/1699 - (29%)
• Gaps: 642/1699 - (37%)

  Fly    33 NLAEDKTLKWRNLA-------NNQFASKEKKHKDKEEEERKE----------------------- 67
            ||.|.:..:..:||       |.|.| .|..|...::|.|:|
  Rat  4394 NLPEAQKPEQSSLAAGRLEQVNGQVA-HEPSHLSIKQEPREEPCALGAQTVKREANGEPAGAPGT 4457

  Fly    68 ------ARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVA 126
                  |.::.|...:  ||..::.|..|:|.........:.|.:...:.:..|:::.......:
  Rat  4458 SNHLLLAGSRSEAGHL--LLQKLLRAKNVQLGAGRGPEGLRAEINGHVDSKLSGQEQKLQGTSSS 4520

  Fly   127 KQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEE---- 187
            |:|:...|.          .|...:|.:|.:..:|:                ::|...||:
  Rat  4521 KEDAAARKP----------LMAKPKRVQKTSDRLAS----------------SRKKLRKEDGVRA 4559

  Fly   188 EPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASV------KLAADATNQMRAATSAGA---- 242
            ...|....|.|.:..|||         .|.:.::.|:      .......:|:|.|..:||
  Rat  4560 NEALLKQLKQELSQLPLT---------EPTITANFSLFAPFGSGCLVGGQSQLRGAFGSGALHTG 4615

  Fly   243 ----ATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQ--VENKKFGKSEQYTDCSSHLERF 301
                :.|..|| .:|...|..|...|.|   |.||..:.|.  ..:::.|:..:....:...||
  Rat  4616 PDYYSQLLTKN-NLSNPPTPPSSLPPTP---PPSVQQKMVNGVTPSEELGEHPKDAASAQDSER- 4675

  Fly   302 TLDDNTAIVRLQLKSEPDKPSLTALSPEENSAPAPKRGRGRARKIRPDAEVETSEVILPC---ED 363
            ||.|...:..|.|        |.||       |.|...:....::..|.:.::.:.|:|.   |.
  Rat  4676 TLKDAAEVKSLDL--------LAAL-------PTPPHNQTEDVRMESDEDSDSPDSIVPASSPES 4725

  Fly   364 SLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWE 428
            .|||:.|                                         |..:||:      ..||
  Rat  4726 ILGEEAP-----------------------------------------RFPQLGS------GRWE 4743

  Fly   429 EVKTEALHPQ-PSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLE----SETSCGLPF 488
            : .|.||.|. |....:...|..:..|..|||.:.|       .|.|....|    ||.|..|..
  Rat  4744 Q-DTRALSPVIPIIPRTSIPVFPDTKPYGVLDLEVP-------GKPPATAWEKGKGSEVSVMLTV 4800

  Fly   489 ANGNKKTNSSGGCELQLPKRSKRRIKPTPKILEND-ELRCEFETKHIERMTQWESAAAVDGDFET 552
            :....|  :..|..:.:.:....:|..:.::|..| ..|...|.|..|
  Rat  4801 SAAAAK--NLNGVMVAVAELLSMKIPNSYEVLFPDGPARAGLEPKKGE----------------- 4846

  Fly   553 PTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPP 617
             |.|..|.....|        |...:.||.......|:......|||.||    .::|.:....|
  Rat  4847 -TEGSGGKEKGLS--------GRGPDTGPDWLKQFDAVLPGYTLKSQLDI----LSLLKQESPAP 4898

  Fly   618 CPDVEQF----LNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDS 678
            .|.::..    ::::...:::|                                     |...:.
  Rat  4899 EPSIQHSYTYNVSNLDVRQLSA-------------------------------------PPPEEP 4926

  Fly   679 SNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTE 743
            |...:...|:......:|.|.|:........:|:...|.|  :|                    |
  Rat  4927 SPPPSPLAPSPASPPAEPMVELQAEPPAEPPIPSPLPLAS--SP--------------------E 4969

  Fly   744 AARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKF----------ICLCQKPSQY 798
            |.|.......||..:                  |.||  .|:.|:          :...||.|
  Rat  4970 ATRPKPRARPPDESE------------------DSRP--PRLKKWKGVRWKRLRLLLTIQKGS-- 5012

  Fly   799 YARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCG 863
             .|..            |::::.   |...::...||||            |....:..||
  Rat  5013 -GRQE------------DEREVA---EFMEQLGTALRPS------------KVPRDNRRCC---- 5045

  Fly   864 IFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERT 928
             ||                             .|.||....|     |..:|   :..||.
  Rat  5046 -FC-----------------------------HEEGDGATDG-----PARLL---NLDLDL---- 5068

  Fly   929 STVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASS 993
             .|.:.|                |..:|..:.||.|.:.|..    .|.::|.|
  Rat  5069 -WVHLNC----------------ALWSTEVYETQGGALMNVE----VALHRGLL----------- 5101

  Fly   994 PASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVM-----NVVLRGHVVSASGRVTAEFTP- 1052
              :|.:..||..| |.:.|.....|..:||..|....|     .::...|.:  .|....|.:.
  Rat  5102 --TKCSLCQRTGA-TGSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKI--KGPCEQELSSF 5161

  Fly  1053 ---RDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPD 1114
               |.:|  ::.|:::::|.|:.             .|..||:....|.:..|.     |...|.
  Rat  5162 AVFRRVY--IERDEVKQIASIIQ-------------RGERLHMFRVGGLVFHAI-----GQLLPH 5206

  Fly  1115 FVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSY 1179
              .:.|:...|||.                         |.|            .|||: |..|.
  Rat  5207 --QMADFHSATALY-------------------------PVG------------YEATR-IYWSL 5231

  Fly  1180 RTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLIN-----------IFL 1233
            ||:.....:...| :::.|....::...|.|..|:|...:.||||:.::|.           :.|
  Rat  5232 RTNNRRCCYRCSI-SENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRL 5295

  Fly  1234 FISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSV 1298
            |..:|..::                       |..:||                        |:|
  Rat  5296 FPEYLKGEE-----------------------LFGLTV------------------------HAV 5313

  Fly  1299 TRMCIALIANGADLMIKNKAEQLP-FDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCADASN 1362
            .|:                ||.|| .:...|.....||.....:.: ...|.|      ||.:
  Rat  5314 LRI----------------AESLPGVESCQNYLFRYGRHPLMELPL-MINPTG------CARS-- 5353

  Fly  1363 GREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSD 1427
              |.:.:...:.......:.|..::||.|.         ..||..:.:...           |:.
  Rat  5354 --EPKILTHYKRVFTSIISFDPHNNLMRPH---------TLNSTSMSKAYQ-----------STF 5396

  Fly  1428 RCQCNGASSQNWYTAES----RLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIV 1488
            ..:.|...|:.:..::|    ||..::                      ||.|....:|
  Rat  5397 TGETNTPYSKQFVHSKSSQYRRLRTEW----------------------KNNVYLARSR------ 5433

  Fly  1489 ECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDSYYFDLDNGHCIDANY 1546
                 .:|.|:.|..::.|.|.|..|.|.|:....|:||       ....|.|.::|.|.|||..
  Rat  5434 -----IQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATL 5493

  Fly  1547 YGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVG 1611
            .|...|:.||||.||.:...|.::.:|    ||...|.|.|..|||:.:||...|...:|:  :.
  Rat  5494 TGGPARYINHSCAPNCVAEVVTFDKED----KIIIISSRRIPKGEELTYDYQFDFEDDQHK--IP 5552

  Fly  1612 CRCLTTTCK 1620
            |.|....|:
  Rat  5553 CHCGAWNCR 5561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	19/123 (15%)
		EHMT_ZBD	786..933	CDD:411018	25/156 (16%)
		ANKYR	1063..1322	CDD:440430	44/269 (16%)
		ANK repeat	1088..1120	CDD:293786	6/31 (19%)
		ANK repeat	1124..1153	CDD:293786	3/28 (11%)
		ANK repeat	1155..1196	CDD:293786	9/40 (23%)
		ANK repeat	1199..1249	CDD:293786	12/60 (20%)
		ANK repeat	1251..1283	CDD:293786	3/31 (10%)
		ANK repeat	1285..1316	CDD:293786	3/30 (10%)
		SET_EHMT	1391..1622	CDD:380941	57/241 (24%)
Kmt2d	XP_063118908.1	None