DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and ehmt1

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_031762692.1	Gene:	ehmt1 / 100124713	XenbaseID:	XB-GENE-5793917	Length:	1277	Species:	Xenopus tropicalis

Alignment Length:	1502	Identity:	407/1502 - (27%)
Similarity:	643/1502 - (42%)	Gaps:	308/1502 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 NAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTP 264
            :||.:.|::.|  ..:.|.:.:..:|..|::..::..| .||...|:||.|..:.|...::....
Frog     5 DAERVDTSQTE--SRNDLFLKTDLLKAIANSQEEVSEA-MAGDENLSDKQVGETNGSCEKNESKE 66

  Fly   265 ---RPIDTPTSVTDEHVQVENKKFGKSE----------QYTDCSSHLERFTLDDNTAIVRLQLKS 316
               ..:.||.|....|.....|.|..:|          ||...:|:..:.::..:...:.
Frog    67 LGLLTLATPDSTKLPHQDCVFKTFRVAENGVYDRDTEGQYPFKASNPTQTSVTGSNGYIL----- 126

  Fly   317 EPDKPSLTALSPEENSAPAPKRGRGRARKIRPDAEVE---TSEVILPCEDSLGEKKPGRKRKLPD 378
              :||::.. .|...|:.:|.  .|.|.|..|.|..:   .|.|.:|...|          .:|.
Frog   127 --NKPAILE-QPLRTSSLSPL--SGHAAKTLPVAASKPKAASNVYVPPAPS----------PVPP 176

  Fly   379 EPIDQQQLSDLVVVKTEQEELGDAPLGDVK--RMRRSVRLGNRLHADGSPWEEVKTEALHPQPSA 441
            .|.|..:     |..|:|:   |:.|.|:|  |.|:::.     ...||       ..:|.:|..
Frog   177 NPGDPGR-----VENTKQQ---DSALPDLKVHRARKTLP-----KTSGS-------SPIHKEPKE 221

  Fly   442 ELSFAEVTSEILPLAVLDEK--------TPPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSS 498
            .....|...|..|...||::        :.|::...:.:.....|.:...|       .||....
Frog   222 PSEQDETKDESAPKNGLDDEKEEPQSPSSAPQQLLPQGQNSAKSLSAALVC-------RKKKRRM 279

  Fly   499 GGCELQLPKRSKRRIKPTPKILENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSS 563
            |...| :||: |.::.....:||           ....:|...|:...:.:.:.|..     |..
Frog   280 GMYSL-VPKK-KTKVPKQRSVLE-----------MFRNITYTSSSPKSEKESDVPHV-----NGE 326

  Fly   564 TSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDI 628
            :....|:..|..:.|....|.:.|.|      |:||   |..|....|.|:......|::.  |.
Frog   327 SMEMDSEDEDSEDMEEEDYHSSETPA------SESQ---EEPGVPKEATSEADSSRKVDEV--DS 380

  Fly   629 KASR-INANRSPEER----KLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPT 688
            :... :.:..|.||.    :.:...:..|.|::||       :|...:.|....|
Frog   381 EGDEDVESGDSVEEEDDGAESDLSSESSLRKKQEK-------KKTLAESPWMKGS---------- 428

  Fly   689 TRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPIST 753
                        |.|....||.|         ||::           .::||..||:.....:|
Frog   429 ------------RRRKRKNKENP---------NPLL-----------ASSGEAREASMEYTEVS- 460

  Fly   754 PDAEQLHSLDTSIQADVTP-IRDLDMRPSTSRVSKF----ICLC--QKPSQYYARNAPDSSYCCA 811
                 |.|||..::..::| ..||........:...    :|.|  :.|.:... :|....:|.|
Frog   461 -----LDSLDLRVKEMLSPQSNDLSNGSEAMELDGLQGIPLCSCRMETPKEEEV-SAKAGEHCMA 519

  Fly   812 IDHIDDQKIG-CCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCK 875
            |:....:::| |.|.::.  :.|:|||.:|.:::||::|:.::..|.||.|||.|||.|.|:.|:
Frog   520 IESTGQEQLGRCTNRVAK--YELMRPSNKVRHLVLCEDHRGKMVKHQCCPGCGYFCTAGTFMECQ 582

  Fly   876 Q----QHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKCQ 936
            .    .|.||.|||.| :.::||                      |||||.:..:.......|..
Frog   583 PDSTISHRFHKDCATR-VNNSSY----------------------CPHCGEEASKAKEVTIAKAD 624

  Fly   937 S----LPVFLRTQKYKIK--PARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPA 995
            :    .||....:|....  .|..||.|........|. |...||:...||....:...:...|.
Frog   625 TTSSLAPVTGEWEKVSAAEGQADTTTESEAMALKAPEE-NKQEATSSLPGGTPEPIETPSLGKPP 688

  Fly   996 SKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQ 1060
            |.:.|..:              .::..|.|..:|.....||.|             |:.:|::.:
Frog   689 SLSQGPVK--------------ETLESALLALDSEKPKKLRFH-------------PKQLYFSAR 726

  Fly  1061 NDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRT 1125
            ..:|::|..:|....:....:.::...|.||..|..|...:.::|:..||:    ::....:.||
Frog   727 QGELQKVLMMLVDGIDPNYKMEQHSRRTPLHAAAEMGYTDICHMLIQAGAN----LDSCSEDQRT 787

  Fly  1126 ALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLS 1190
            .||.|..|...|.:...::.||.:..|..:|.|.||:||:.|:.|..:.::.|.||.
Frog   788 PLMEAAENNHLDTVKYLVKGGALIDPKDSEGSTCLHLAAKKGHYEVVKYLLSSERTD-------- 844

  Fly  1191 FIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTV 1255
             ::.||:||||.|:||.|..|.:||:|                    |.:..||.||.||:.|..
Frog   845 -VNCQDDGGWTPMIWATEYKHVEIVKL--------------------LHSSRADVNIRDNEENIC 888

  Fly  1256 LHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQ 1320
            |||:.... .::...:||.|..|....|:.||:|||||.|.:.....:..:.:|:::.:|||..:
Frog   889 LHWAAFAG-SVEIAEILLASKCDLRAVNIHGDSPLHIAARENRHECVMLFLGHGSEVGLKNKEGE 952

  Fly  1321 LPFDC-IPNEE-----SECGRTVGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMS 1379
            .|.:| .||.:     |:|        |....:|. |:..||..|.|.|.|..||..|..|
Frog   953 TPLECSAPNSDVWAALSKC--------QALPEKPT-LQEKVVDRDISRGYENIPIPCVNAE---- 1004

  Fly  1380 ENEDEADSLMWP-DFRYVTQ-CIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTA 1442
                  ||.:.| :::||:| |:  .:.:.|||.::.::.|.|:|.|||..|.|...|.:.||..
Frog  1005 ------DSELCPVNYKYVSQNCV--TSPLNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDK 1061

  Fly  1443 ESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPK 1507
            ..||..:||..:|.:|||||..|.|.: :|:|||||||.:..||:.  ..::||||||:|.::|:
Frog  1062 NGRLLPEFNMLEPPLIFECNHACSCWR-NCRNRVVQNGLKIRLQLF--RTKSKGWGVRSLQDIPQ 1123

  Fly  1508 GTFVGSYTGEILTAMEADRRTDDSYYFDLDNG----HCIDANYYGNVTRFFNHSCEPNVLPVRVF 1568
            ||||..|.||:::..|||.|.||:|.|||||.    :||||.:|||::||.||.||||:||||||
Frog  1124 GTFVCEYVGELISDAEADVREDDTYLFDLDNKDREVYCIDARFYGNISRFINHLCEPNLLPVRVF 1188

  Fly  1569 YEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCKYASQSSSTNASPT 1633
            ..|||.|||:|.|||.|.|.|||||.||||::||.|:.: ...|:|.:..||:..:..|.:.|.|
Frog  1189 MSHQDLRFPRIGFFSSRHIGAGEEIGFDYGDRFWDVKGK-LFSCQCGSPKCKHPIKVLSPSQSFT 1252

  Fly  1634 NATTAPE 1640
            .|.|..|
Frog  1253 PAETPSE 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	11/47 (23%)
		Ank_2	1056..1152	CDD:289560	21/95 (22%)
		ANK	1088..1217	CDD:238125	42/128 (33%)
		ANK repeat	1088..1120	CDD:293786	8/31 (26%)
		ANK repeat	1124..1153	CDD:293786	9/28 (32%)
		Ank_2	1127..1249	CDD:289560	38/121 (31%)
		ANK	1155..1306	CDD:238125	49/150 (33%)
		ANK repeat	1155..1196	CDD:293786	11/40 (28%)
		ANK repeat	1199..1249	CDD:293786	16/49 (33%)
		Ank_2	1205..1316	CDD:289560	32/110 (29%)
		ANK repeat	1251..1283	CDD:293786	8/31 (26%)
		ANK repeat	1285..1316	CDD:293786	9/30 (30%)
		PreSET	1357..1466	CDD:128744	39/110 (35%)
		SET	1495..1602	CDD:214614	69/110 (63%)
ehmt1	XP_031762692.1	EHMT_ZBD	495..622	CDD:411018	44/152 (29%)
		Ank_2	721..815	CDD:403870	21/97 (22%)
		ANK repeat	753..782	CDD:293786	8/32 (25%)
		ANK repeat	784..815	CDD:293786	9/30 (30%)
		Ank_2	789..882	CDD:403870	38/121 (31%)
		ANK repeat	817..849	CDD:293786	11/40 (28%)
		ANK repeat	851..882	CDD:293786	17/50 (34%)
		Ank_2	856..948	CDD:403870	33/112 (29%)
		ANK repeat	884..915	CDD:293786	8/31 (26%)
		ANK repeat	917..948	CDD:293786	9/30 (30%)
		SET_EHMT1	1011..1241	CDD:380933	116/235 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1609
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	1	1.000	-	-		FOG0003434
OrthoInspector	1	1.000	-	-		otm48686
Panther	1	1.100	-	-	O	PTHR46307
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160