DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and nsd2

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001076020.1	Gene:	nsd2 / 100000709	ZFINID:	ZDB-GENE-030131-2581	Length:	1461	Species:	Danio rerio

Alignment Length:	1738	Identity:	308/1738 - (17%)
Similarity:	515/1738 - (29%)	Gaps:	682/1738 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 KQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTE-----------RWENESFK------ 174
            ||.|:....:||....||   :......|.||::|.|..|           ...:|..|
Zfish    22 KQLSDSPGGRNGLVDGIT---DPTMLMNKAATQLAATPQESVPQMIGSHGHNHTHEHLKDLTSRL 83

  Fly   175 ----TEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASP---LVVSSASVKLA----- 227
                ||:..|..|....:|:|...:.:..:|.|...|.:     ||   :.::...|.|.
Zfish    84 LNGDTEKIPKLCAAPAGQPLLKGVEPVSQHASPPRKTSV-----SPELTVKITKCVVNLGGKPNR 143

  Fly   228 --ADATNQMRAATSAGAATLADKNVQVSPGGTR---------RSRRTPRPI-------------- 267
              .|.|.:  .|....|.....:.|..||...|         |.|..|.||
Zfish   144 YEVDYTEE--KAEETDAPLRLPEGVLTSPTARRDRQKKKGMVRKRIPPYPILTHAASSDQSPLLH 206

  Fly   268 -------------------------DTPTSVT---DEH-------------------VQVENKKF 285
                                     |.||.||   ||.                   .|.||
Zfish   207 PTINSNDITIEPCGLPVESIEHTHGDMPTCVTAFPDEQPLSDCEETVDAQGVDETDDAQGEN--- 268

  Fly   286 GKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTALSPEENS------------------ 332
            ...|.||:..|:: .|::.|   ::..::...|..|.:....||.|.
Zfish   269 DVKESYTETQSNV-HFSVGD---VIWTKVSGYPWWPCMITTDPEFNMHFRSKVNSRTGLLYHVQY 329

  Fly   333 -APAPKRGRGRARKI-----RPDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVV 391
             ...|:||....:.|     :...:..:....||...|      ||||.:|.:...:.::.
Zfish   330 FGDTPERGYVFEKCIVTFSGKHQYQSLSRSNQLPINIS------GRKRAVPRKFRQKWEIG---- 384

  Fly   392 VKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSP---------WEEVKTEALHPQPSAELSFAE 447
            |...:|.||   |...:|:.:.    :.::.||..         .||.:.:.|..:|
Zfish   385 VSQAKEALG---LLTEERLAKF----SFVYEDGKAQLNPHMLQVLEEQRNQGLQEEP-------- 434

  Fly   448 VTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSCGLP--FANGNKKTNSSGGCELQLPKRSK 510
            |..|...|..|   |||.      .|......|.|:..:|  |:|....:.|||  :..||::::
Zfish   435 VQREPQELVSL---TPPD------STHSSPTNSSTTSTIPSLFSNPIDSSTSSG--KTALPRKAR 488

  Fly   511 RRIKPTPKI------------------------LENDELRCEFETKHI--------ERMTQWESA 543
               ||:.|.                        |....::||..|:|.        :|..:.:..
Zfish   489 ---KPSVKTNRRKQRSSTIEWIVTEASSAKQMPLTESTVQCEVNTEHKKKGKTNAGKRPYRKKDL 550

  Fly   544 AAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAA 608
            ..:|.|.:...:           ||..:.....|      ||..:::|||..
Zfish   551 LCIDLDLQPKAS-----------QKKPRHIRQKF------PAAPNSVKKRKI------------- 585

  Fly   609 MLAKSKLPPCPDVEQF-----LNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHLKHLGLQKN 668
               |:.:..|..:...     |:::||| ..:.:..|:...:.|..:|:.|:..:..:.:.||..
Zfish   586 ---KAGVSICDTLNTVSTSAGLSEVKAS-APSTKLWEKEDASSKGMKKVCKRSRESKQDVTLQPK 646

  Fly   669 HRDEPSDNDSSNTDNEF------FPTTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAA 727
            .:        |..:.:|      ...:......|:...|.|.:...|....:...|:..|..:|.
Zfish   647 KK--------SKLEKDFKKWKCPKAASSAPAAVPAPRGRRRKTDRDENRKRSKKASKEEPPPKAK 703

  Fly   728 KLTRRIGARAAGEVTEAARASVPIS------------TPDAEQLHSLDTSIQADVTPIRDLDMRP 780
            :..:|        ..|:.|.|.|.|            .||:.. .|.|.|     .|.:..:..|
Zfish   704 RGRKR--------KEESGRQSFPASKKCRPSSYAEPERPDSPS-DSTDES-----HPSKKAERTP 754

  Fly   781 STSRVSKFICL-CQKPSQ------------YYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHN 832
            ...:.|  :|| |::..:            |:.       :|..::. ..:|| .|...|:.||
Zfish   755 GAKKES--VCLVCEQTGEDIVTCAGQCYGTYHL-------HCIGVER-SAEKI-LCTACSTGVH- 807

  Fly   833 LLRPSQRVSYMILCDEHKK-RLQSHNCCA-GCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYE 895
                        :|...|| ..:...||| .||              .|:|..|.:...|:..
Zfish   808 ------------VCFTCKKSEGEVRRCCALHCG--------------RFYHEACVRLSALTVF-- 844

  Fly   896 KELGDEEDQGVKFSSPV-LVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSH 959
                  |::|  |..|: ..|.|.:.|....:.|....|:|...||
Zfish   845 ------ENRG--FRCPLHTCLSCHYSGRAACKATKGKMMRCLRCPV------------------- 882

  Fly   960 LTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQ 1024
                            |.:.|.|..|......||.|.......|.:.|.|:    |:..::::.
Zfish   883 ----------------AYHVGDLCVAAGSEMISSSAIVCTNHFRAKKGYSH----HSHVNVSWC- 926

  Fly  1025 LIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTC 1089
                         .:.|..||:..                   .|...|.|          :..|
Zfish   927 -------------FICSKGGRLLC-------------------CESCPAAF----------HPDC 949

  Fly  1090 LHLVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGP 1154
            |::....|:.   :...|:....|.:.::
Zfish   950 LNIAMPDGSW---FCNDCRSGKKPKYRDV------------------------------------ 975

  Fly  1155 DGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLAS 1219
                   |..:|||          ||                   |    |.||:.|
Zfish   976 -------IWVKLGN----------YR-------------------W----WPAEIRH-------- 992

  Fly  1220 LPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNV 1284
             |:.:                                                     ..|:|::
Zfish   993 -PKNI-----------------------------------------------------PTNIQHL 1003

  Fly  1285 EGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPL 1349
                      ||.:....:....: .|....::....|:     .|.:.|         ..::..
Zfish  1004 ----------RHEIGEFPVFFFGS-KDYFWTHQGRVFPY-----MEGDRG---------SKYQQT 1043

  Fly  1350 GLRTFVVCADASNGREAR--PIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRV 1412
            |:..  |..:|....|.|  .|::.|......||..:.     |.|:|          :::::..
Zfish  1044 GIGK--VFKNALLDAETRFKEIEMEREAKEAHENNKKP-----PPFKY----------IKVNKPC 1091

  Fly  1413 SQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRV 1476
            .::::.:. |.....:|.|..::.:........||.       .:::||: .||...: .|:|:.
Zfish  1092 GRVQVYTA-DISEIPKCNCKPSTERPCSFESECLNR-------MLLYECHPQVCPAGE-RCQNQD 1147

  Fly  1477 VQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDS--------YY 1533
            .........:|:  ....||||:.:|.::.||.||..|.||::...|...|...:        |.
Zfish  1148 FTKRLYPETKII--RTAGKGWGLISLRDIKKGEFVNEYVGELIDEEECRSRIRHAQENDITHFYM 1210

  Fly  1534 FDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRF---PKIAFFSCRDIDAGEEICF 1595
            ..:|....|||...||.:||.||||:||.       |.|.:..   .::..|:..||.||.|:.|
Zfish  1211 LTIDKDRIIDAGPKGNYSRFMNHSCQPNC-------ETQKWTVNGDTRVGLFAVCDIPAGTELTF 1268

  Fly  1596 DYGEKFWRVEHRSCVG-----CRCLTTTCKYASQSSSTNASPTNATTA 1638
            :|        :..|:|     |||....|     |......|.|..|:
Zfish  1269 NY--------NLDCLGNEKTVCRCGAPNC-----SGFLGDRPKNGHTS 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	25/128 (20%)
		Ank_2	1056..1152	CDD:289560	8/95 (8%)
		ANK	1088..1217	CDD:238125	16/128 (13%)
		ANK repeat	1088..1120	CDD:293786	5/31 (16%)
		ANK repeat	1124..1153	CDD:293786	0/28 (0%)
		Ank_2	1127..1249	CDD:289560	12/121 (10%)
		ANK	1155..1306	CDD:238125	16/150 (11%)
		ANK repeat	1155..1196	CDD:293786	6/40 (15%)
		ANK repeat	1199..1249	CDD:293786	6/49 (12%)
		Ank_2	1205..1316	CDD:289560	10/110 (9%)
		ANK repeat	1251..1283	CDD:293786	1/31 (3%)
		ANK repeat	1285..1316	CDD:293786	3/30 (10%)
		PreSET	1357..1466	CDD:128744	18/111 (16%)
		SET	1495..1602	CDD:214614	39/117 (33%)
nsd2	NP_001076020.1	PWWP	283..394	CDD:295359	23/126 (18%)
		DTHCT	688..>758	CDD:285332	16/83 (19%)
		PHD_SF	761..803	CDD:304600	8/50 (16%)
		PHD_SF	808..854	CDD:304600	16/69 (23%)
		PHD_SF	855..908	CDD:304600	15/87 (17%)
		PHD4_NSD2	925..965	CDD:277127	9/85 (11%)
		WHSC1_related	970..1063	CDD:99899	26/257 (10%)
		AWS	1103..1153	CDD:197795	10/57 (18%)
		SET	1154..1277	CDD:214614	41/139 (29%)
		PHD_SF	1329..1371	CDD:304600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840