Protein Alignment HIVEP1 and shn

DIOPT Version :10

• Sequence 1: XP_011512850.1
• Gene: HIVEP1 / 3096
• HGNCID: 4920
• Length: 2727
• Species: Homo sapiens
• Sequence 2: NP_001260883.1
• Gene: shn / 36171
• FlyBaseID: FBgn0003396
• Length: 2587
• Species: Drosophila melanogaster
• Alignment Length: 2949
• Identity: 639/2949 - (21%)
• Similarity: 985/2949 - (33%)
• Gaps: 978/2949 - (33%)

Human    63 VAENHLKKIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPVKNGKQFTKQNGETPGI 127
            |..||:       :.|.....:..||..::       :.:|...|.|. :|..:|
  Fly   193 VDSNHI-------ISNNNNNNNNNNTSNNN-------NNNHHSDNSIS-ENNYEF---------- 232

Human   128 IAEASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLDEQCDSSSLSSKTRTDNSECISSH 192
               .|:.:.|:|..| :.|||.:.:    |...:|...:..:...:||.::|:..|.|:...:..
  Fly   233 ---KSRDKASLSDSK-MTLQQMAAV----SSNQEPVAPNVANTMSNSSIINSQQTTVNATPATDE 289

Human   193 CGTTSPS----YTNTAFDVLLKAMEPELSTLSQKG-----SPCAIKTEKLRPNKTARSPPKLKNS 248
            ......|    |.:..|..|....|.:..:.:..|     |..|::|..|..|.:...||
  Fly   290 APLGDRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPP----- 349

Human   249 SMDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGAMQSASHLYHQHEHFVPKSNQ-----HNQ 308
              ..|......|:.:.||       |....|:.:|......|...|:.......||.     |.:
  Fly   350 --TTPLANGHHLMTQQQS-------HQQVQQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEE 405

Human   309 QLPGCSGFTGS------LTNLQNQENAKLEQVYNIAVTSSVGLTSPSSRSQVTPQNQQMDSASPL 367
            .:...||:..:      |.|..:..|:......|.|..:::   ||:|.:    |:||:  ..|.
  Fly   406 SIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATL---SPASFA----QHQQL--TQPT 461

Human   368 SISPANSTQSPPMPIYNSTHVASVVNQSVEQMCNLLLKDQKPKKQGKYICEYCNRACAKPSVLLK 432
            ::||.       :|     ..|:..|.:.|             |.|:|:|:|||..|||||||.|
  Fly   462 TVSPG-------IP-----GGAAAPNPACE-------------KSGRYVCQYCNLICAKPSVLEK 501

Human   433 HIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKL-GLVLQPDAGGLFLSHESPKALSIHS 496
            |||:||.||||||.|||.:||||||||||.:|.:|..:. ||.:..||
  Fly   502 HIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADA----------------- 549

Human   497 DVEDSGESEEEGATDERQHDL----GAMELQPVHIIKRMSNAETLLKSSFTPSSPENVIGDFLLQ 557
               |.|.|:::........:|    |:...:|::......:..:..||::....|...    .:|
  Fly   550 ---DDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPT----YMQ 607

Human   558 DRSAESQAVTELPKVVV--HHVTVSPLRTDSPKAMDPKP----------------ELSSAQKQKD 604
            .....|.|...||....  ||...:..|    :::|.||                ||...|:|..
  Fly   608 QLPLGSPAAGTLPPTTADNHHSATAQHR----QSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQ 668

Human   605 LQVTNVQ------------PL-------SANMSQGGVSRLETNENSHQKGDMNPLEGKQDSHVGT 650
            :|....|            ||       ...:|.....:::.:.||||
  Fly   669 IQQQQQQHQLAQQKLSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQ----------------- 716

Human   651 VHAQLQRQQATDYSQEQQGKLLSPRSLGST----DSGYFSRSESA-------------------- 691
            :..|||:||    |...|..||:....|..    ...|:::..:|
  Fly   717 IQLQLQQQQ----SLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQ 777

Human   692 --DQTVSPP----TPFARRLPS-TEQDSGRSNGPSAALVTT-STPSALPTGEKALLLPGQMRPPL 748
              .|...||    ||..::.|| ..|...|:|...:::.|. :||:  |....:..........:
  Fly   778 QQQQQQHPPLVKATPPMQQPPSLPPQQLVRANSQISSVATAPATPT--PAANLSTFASSSGGKQV 840

Human   749 ATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPVGRRTS 813
            ....::|.||||||.|||:|::|::...|.....|||..|.::..|
  Fly   841 NVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANS------------------- 886

Human   814 SSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPANIIPPPHPLRGSQSFDD 878
                                             .:.|...:..||:.||         .||
  Fly   887 ---------------------------------NNASQHGSNASALHAN---------NSQ---- 905

Human   879 KIGAFYDDVFVSGPNAPVPQSGHPRTLVRQAAIEDSSANESHVLGTGQSLDESHQGCHAAGEAMS 943
                       :..||.:|:             .::..|
  Fly   906 -----------NNTNAQMPE-------------RETKVN-------------------------- 920

Human   944 VRSKALAQGPHIEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAMREPEH 1008
                 |||.  |.:|:.||.:... :.:..:.:.::||    .:.:|.......:.:....||
  Fly   921 -----LAQA--IFQKQQHQLQQQQ-QQQITQQQQQQLE----QQNYYTYIQQQQECQQQQLEP-- 971

Human  1009 SPVPGGLQPQILHYRVAGSSGIWEQTPQIRKRRKMKSVGDDEELQQNESGTSPKSSEGLQFQNAL 1073
               |.|:..     |.|...|:...||.             ::.||.....||...:.:|::.
  Fly   972 ---PNGVVK-----RNAYKPGVVMTTPV-------------KQQQQLPPPPSPLPMQTMQYRQ-- 1013

Human  1074 GCNPSLPKHNVTIRSDQQHKNIQLQNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRH 1138
              :|:.|   ||        .|:...:.:.::.........|.|.|:....:|
  Fly  1014 --DPATP---VT--------KIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLS------------ 1053

Human  1139 GTGISVIQHTNSLS-RPNSFDKPEPFERASPVSFQELNRTGKSGSLKVIGISQEESHPSRDGSHP 1202
                     |:||: .|.:...|....:.:|...|..|...|:..|...|::.    |..:|
  Fly  1054 ---------TSSLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAV----PIGEG--- 1102

Human  1203 HQLALSDALRG-ELQESSRKSPSERHVLGQPSRLVRQHNIQVPEILVTEEPDRDLEAQCHDQEKS 1266
                 .||:.. .:..|..:|..:          ::.||                ...|.|...|
  Fly  1103 -----DDAVYSCPICASEFRSADD----------LKLHN----------------STYCQDASSS 1136

Human  1267 EKF---SWPQRSETLS-KLPTEK--LPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTS 1325
            ...   |.|.||.::| .||..|  :...|..|.||::..|..::...|.:...||...:.:.||
  Fly  1137 APMSPASSPFRSNSISLSLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTS 1201

Human  1326 SFSASLDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSMEVS 1390
            :.:|.      :.|.::|            .|| :.|:..|                  :|....
  Fly  1202 TVTAP------TVTASAP------------APA-VATVTAP------------------SSAPAP 1229

Human  1391 DLRSKSFDCGSITPP----QTTPLTELQPPSSPSR----VGVTG-HVP---LLERRRGPLVRQIS 1443
            .:.:..|....:..|    ..|||.:....|:|.:    |.:|. |..   ::|.:....::...
  Fly  1230 QIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSD 1294

Human  1444 LNIAPDSHLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAETS--- 1505
            |.:|..|.    .||||                        .||.|..:|...|.:||:...
  Fly  1295 LVVASSSQ----QPTSF------------------------NFSFNNQNSSNSVPELQSSKEERL 1331

Human  1506 ---NSSSTNVFPVQQLCDI-NLLNQIHAP----PSHQSTQLSLQVSTQGSKPDKN--SVLSGSSK 1560
               .||..::.|:.:..|: |....|..|    .|.|...:.:...|..|..::.  :::|||..
  Fly  1332 RRFTSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGL 1396

Human  1561 SEDCFAPKYQLHCQVFTSGPSCSSNPVHSLPNQVISD---PVGTDHCVTSATLPTKLIDSMSNSH 1622
            ......|:   |.|........:.||: :||.....|   ||.....|.....|..|...|
  Fly  1397 LGVSSGPQ---HFQFPPINSITAFNPL-TLPPMSGGDKTTPVTPIPHVPGMPGPGSLTPQM---- 1453

Human  1623 PLLPPELRPLGSQVQKVPSSFMLPI---RLQSSVPAYCFATLTSLPQILVTQDLPNQPICQTNHS 1684
            |||||.           |....|||   |.:|                      ||:
  Fly  1454 PLLPPP-----------PQQLQLPIPSSRGRS----------------------PNR-------- 1477

Human  1685 VVPISEEQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPITQKISVGRLSPQQES 1749
                  :|.| |.|..|....|.........:||.||.|:.       |.|   ...|.:.|..|
  Fly  1478 ------KQPS-PLLLGGGSGELKALSPFGGVQNVPSEFSRQ-------PPT---PAQRQALQWNS 1525

Human  1750 SASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALSSRVNEASKQKKPILVRQVCTT 1814
            ..:.|:  :|.|.|.:|          :|......:||....  ..|....:|:.|:....|.|.
  Fly  1526 KEAPKK--APFNFLRMA----------DNVKTTEPEVRHFNL--ENVISGKQQELPLTPLHVDTP 1576

Human  1815 EPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTGCSKFVVIEPISELQEFENIKSSTSLTLT 1879
            ..           :.||.::..        |..|::..|||  :.|             |||.|
  Fly  1577 NG-----------NAPEETSPV--------ASASASAKSKF--LRP-------------TSLPL- 1606

Human  1880 VRSSP---APSENTHISPLKCTDNNQERKSPGVKNQGDKVNIQEQSQQPVTSLSLFNI-KDTQQL 1940
               .|   .|..:..|:|   |.|.....||               :.|..|.|...: .:....
  Fly  1607 ---KPGTFTPKRHHGITP---TANTLPLISP---------------ETPRPSKSCVQLYLNGHAY 1650

Human  1941 AFPSLKTTTNFTWCYLLRQKSLHLPQKD-----QKTSAYTDWTVSASN-PNPLGLPTKVALALLN 1999
            .:..||.:|...:|      :::.||..     .|.|.|:.|.|...| |:|||...|..:||.:
  Fly  1651 TYLGLKCSTKMFYC------TVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYD 1709

Human  2000 SKQ------------NTGKSLYCQAITTHSKSDLLVYSSKWKSSLSKRALGNQKS----TVVEFS 2048
            |:|            .:||..|     ....|..:|.|....|:.|....|..|:    |:...|
  Fly  1710 SRQRMLGNGSSTAMAGSGKLSY-----NLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTIAALS 1769

Human  2049 NKD-ASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSML 2112
            ..: |::.|.|...:.  :::.|....:. |||:|:|:|.|:||||||:|:|.||||||||||||
  Fly  1770 EANVAAKANEEAQAKK--LETSPSGQPLV-GGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSML 1831

Human  2113 KKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRF 2177
            ||||||||||||:.|::|||||||||||||||:||.|.|||::||::.|.: ..|:|..|....|
  Fly  1832 KKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPM-PPDSEFLDVDMDF 1895

Human  2178 SYE-------RSGYDLEESDGPDEDDNENEDDDEDS----QAES-------VLSATPSVTASPQH 2224
            ..:       |:.....|||..|..|||:|..|.|.    |.|.       .||.||.:   ||.
  Fly  1896 DQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARGLLSLSMTPPI---PQS 1957

Human  2225 LPSRSSLQDPVSTDEDVRITDCFSGVHTDPMDVLPRALLTRMTVLSTAQSDYNRKTLSPGKARQR 2289
            :.....|||                              |.:...|.|.|     ..|.|...:|
  Fly  1958 VSPYPQLQD------------------------------TPLPAASPANS-----IGSSGSQPKR 1987

Human  2290 AARDENDTIPSVDTSRSPCH---------QMSVDYPESEEILRSSMAGKAVAITQSPSSVRLPPA 2345
            .........|..|..:...:         :.||...||..:..:...|..:.|:.||.||   ||
  Fly  1988 LVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSV---PA 2049

Human  2346 AAEHSPQTAAGMPSVASPHPDPQEQKQQITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVPV 2410
                              |..|:.|.||:           |..:|.    .|..:|.....::.|
  Fly  2050 ------------------HDLPKSQAQQM-----------HDVIFG----TSGNESGFMKTLISV 2081

Human  2411 GGIHVVPAGL----------------TYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSG 2459
            .....:.|.:                ||.....|....::.:..:.|.:..||.|..:.|...|.
  Fly  2082 SDKVRISAEMEEQAKHEAEGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSS 2146

Human  2460 TTNPAGVAELSSV--VPCIPIGQIRVPGLQNLSTPG---------LQSLPSLSMETVNIVGLANT 2513
            |...|....:.||  ||.|.:.:::.|  :.:.:|.         |..:.....|..||....|.
  Fly  2147 TLFTANSRPVMSVNEVPSIEVHEVKTP--EAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNA 2209

Human  2514 NM-----APQVH-----------PPGLALNAVGLQVLTANPSSQSS------PAPQAHIPGLQIL 2556
            |:     .|.|:           ||..::.|..:...||.|.:.||      ||.:..|.|....
  Fly  2210 NLPAAVQQPDVNEFTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGF 2274

Human  2557 NIALPTLIPSVSQVAVDAQGAPEMPASQ---------SKA---------------------CE-- 2589
            ..:.||......|.....:|.|..|.:.         ||.                     ||
  Fly  2275 KSSTPTSKSGDLQHVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPC 2339

Human  2590 ---------TQPKQTSVASANQVSRTESPQGLPT------------------------------- 2614
                     .|..:.|.|..|:|..| |..|:||
  Fly  2340 SISFRTQGHLQKHERSEAHKNKVMMT-STFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLRSKTH 2403

Human  2615 VQRENAKKVLNPPAPAGDHARLD----GLSKMDTEKAASANHVKPKPELTSIQ--GQPASTSQPL 2673
            ||:....:.|    |.|.:|.::    .|:::||....::        |.|::  .|......|
  Fly  2404 VQKLECLQKL----PFGTYAEIERAGISLTEIDTSDCENS--------LISLKLLAQKLQEKDP- 2455

Human  2674 LKAHSEVFTKPSGQQTLSPDRQVP 2697
              .....:|.|||...|:.|...|
  Fly  2456 --GKLSSYTTPSGMMQLAQDAAGP 2477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIVEP1	XP_011512850.1	C2H2 Zn finger	417..437	CDD:275368	15/19 (79%)
		zf-H2C2_2	430..454	CDD:463886	17/23 (74%)
		C2H2 Zn finger	445..465	CDD:275368	14/19 (74%)
		zf-C2H2	2097..2119	CDD:395048	19/21 (90%)
		C2H2 Zn finger	2099..2119	CDD:275370	18/19 (95%)
		zf-H2C2_2	2111..2136	CDD:463886	20/24 (83%)
		zf-C2H2_2	<2125..2190	CDD:463690	31/71 (44%)
		C2H2 Zn finger	2127..2145	CDD:275370	15/17 (88%)
		PHA03247	<2272..2634	CDD:223021	93/491 (19%)
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368	15/19 (79%)
		zf-H2C2_2	499..523	CDD:463886	17/23 (74%)
		C2H2 Zn finger	514..536	CDD:275368	15/21 (71%)
		PRK12323	<1185..>1269	CDD:481241	20/120 (17%)
		zf-C2H2	1816..1838	CDD:395048	19/21 (90%)
		C2H2 Zn finger	1818..1838	CDD:275370	18/19 (95%)
		zf-H2C2_2	1830..1855	CDD:463886	20/24 (83%)
		zf-C2H2	1844..1868	CDD:395048	18/23 (78%)
		C2H2 Zn finger	1846..1868	CDD:275370	18/21 (86%)
		zf-C2H2_8	<2305..2352	CDD:464935	5/46 (11%)
		C2H2 Zn finger	2308..2328	CDD:275368	2/19 (11%)
		zf-C2H2_jaz	2333..2359	CDD:432381	5/25 (20%)
		C2H2 Zn finger	2336..2358	CDD:275368	4/21 (19%)
		C2H2 Zn finger	2381..2403	CDD:275368	0/21 (0%)