DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HIVEP1 and shn

DIOPT Version :9

Sequence 1:XP_011512848.1 Gene:HIVEP1 / 3096 HGNCID:4920 Length:2727 Species:Homo sapiens
Sequence 2:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster


Alignment Length:2949 Identity:639/2949 - (21%)
Similarity:985/2949 - (33%) Gaps:978/2949 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    63 VAENHLKKIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPVKNGKQFTKQNGETPGI 127
            |..||:       :.|.....:..||..::       :.:|...|.|. :|..:|          
  Fly   193 VDSNHI-------ISNNNNNNNNNNTSNNN-------NNNHHSDNSIS-ENNYEF---------- 232

Human   128 IAEASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLDEQCDSSSLSSKTRTDNSECISSH 192
               .|:.:.|:|..| :.|||.:.:    |...:|...:..:...:||.::|:..|.|:...:..
  Fly   233 ---KSRDKASLSDSK-MTLQQMAAV----SSNQEPVAPNVANTMSNSSIINSQQTTVNATPATDE 289

Human   193 CGTTSPS----YTNTAFDVLLKAMEPELSTLSQKG-----SPCAIKTEKLRPNKTARSPPKLKNS 248
            ......|    |.:..|..|....|.:..:.:..|     |..|::|..|..|.:...||     
  Fly   290 APLGDRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPP----- 349

Human   249 SMDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGAMQSASHLYHQHEHFVPKSNQ-----HNQ 308
              ..|......|:.:.||       |....|:.:|......|...|:.......||.     |.:
  Fly   350 --TTPLANGHHLMTQQQS-------HQQVQQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEE 405

Human   309 QLPGCSGFTGS------LTNLQNQENAKLEQVYNIAVTSSVGLTSPSSRSQVTPQNQQMDSASPL 367
            .:...||:..:      |.|..:..|:......|.|..:::   ||:|.:    |:||:  ..|.
  Fly   406 SIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATL---SPASFA----QHQQL--TQPT 461

Human   368 SISPANSTQSPPMPIYNSTHVASVVNQSVEQMCNLLLKDQKPKKQGKYICEYCNRACAKPSVLLK 432
            ::||.       :|     ..|:..|.:.|             |.|:|:|:|||..|||||||.|
  Fly   462 TVSPG-------IP-----GGAAAPNPACE-------------KSGRYVCQYCNLICAKPSVLEK 501

Human   433 HIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKL-GLVLQPDAGGLFLSHESPKALSIHS 496
            |||:||.||||||.|||.:||||||||||.:|.:|..:. ||.:..||                 
  Fly   502 HIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADA----------------- 549

Human   497 DVEDSGESEEEGATDERQHDL----GAMELQPVHIIKRMSNAETLLKSSFTPSSPENVIGDFLLQ 557
               |.|.|:::........:|    |:...:|::......:..:..||::....|...    .:|
  Fly   550 ---DDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPT----YMQ 607

Human   558 DRSAESQAVTELPKVVV--HHVTVSPLRTDSPKAMDPKP----------------ELSSAQKQKD 604
            .....|.|...||....  ||...:..|    :::|.||                ||...|:|..
  Fly   608 QLPLGSPAAGTLPPTTADNHHSATAQHR----QSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQ 668

Human   605 LQVTNVQ------------PL-------SANMSQGGVSRLETNENSHQKGDMNPLEGKQDSHVGT 650
            :|....|            ||       ...:|.....:::.:.||||                 
  Fly   669 IQQQQQQHQLAQQKLSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQ----------------- 716

Human   651 VHAQLQRQQATDYSQEQQGKLLSPRSLGST----DSGYFSRSESA-------------------- 691
            :..|||:||    |...|..||:....|..    ...|:::..:|                    
  Fly   717 IQLQLQQQQ----SLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQ 777

Human   692 --DQTVSPP----TPFARRLPS-TEQDSGRSNGPSAALVTT-STPSALPTGEKALLLPGQMRPPL 748
              .|...||    ||..::.|| ..|...|:|...:::.|. :||:  |....:..........:
  Fly   778 QQQQQQHPPLVKATPPMQQPPSLPPQQLVRANSQISSVATAPATPT--PAANLSTFASSSGGKQV 840

Human   749 ATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPVGRRTS 813
            ....::|.||||||.|||:|::|::...|.....|||..|.::..|                   
  Fly   841 NVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANS------------------- 886

Human   814 SSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPANIIPPPHPLRGSQSFDD 878
                                             .:.|...:..||:.||         .||    
  Fly   887 ---------------------------------NNASQHGSNASALHAN---------NSQ---- 905

Human   879 KIGAFYDDVFVSGPNAPVPQSGHPRTLVRQAAIEDSSANESHVLGTGQSLDESHQGCHAAGEAMS 943
                       :..||.:|:             .::..|                          
  Fly   906 -----------NNTNAQMPE-------------RETKVN-------------------------- 920

Human   944 VRSKALAQGPHIEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAMREPEH 1008
                 |||.  |.:|:.||.:... :.:..:.:.::||    .:.:|.......:.:....||  
  Fly   921 -----LAQA--IFQKQQHQLQQQQ-QQQITQQQQQQLE----QQNYYTYIQQQQECQQQQLEP-- 971

Human  1009 SPVPGGLQPQILHYRVAGSSGIWEQTPQIRKRRKMKSVGDDEELQQNESGTSPKSSEGLQFQNAL 1073
               |.|:..     |.|...|:...||.             ::.||.....||...:.:|::.  
  Fly   972 ---PNGVVK-----RNAYKPGVVMTTPV-------------KQQQQLPPPPSPLPMQTMQYRQ-- 1013

Human  1074 GCNPSLPKHNVTIRSDQQHKNIQLQNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRH 1138
              :|:.|   ||        .|:...:.:.::.........|.|.|:....:|            
  Fly  1014 --DPATP---VT--------KIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLS------------ 1053

Human  1139 GTGISVIQHTNSLS-RPNSFDKPEPFERASPVSFQELNRTGKSGSLKVIGISQEESHPSRDGSHP 1202
                     |:||: .|.:...|....:.:|...|..|...|:..|...|::.    |..:|   
  Fly  1054 ---------TSSLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAV----PIGEG--- 1102

Human  1203 HQLALSDALRG-ELQESSRKSPSERHVLGQPSRLVRQHNIQVPEILVTEEPDRDLEAQCHDQEKS 1266
                 .||:.. .:..|..:|..:          ::.||                ...|.|...|
  Fly  1103 -----DDAVYSCPICASEFRSADD----------LKLHN----------------STYCQDASSS 1136

Human  1267 EKF---SWPQRSETLS-KLPTEK--LPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTS 1325
            ...   |.|.||.::| .||..|  :...|..|.||::..|..::...|.:...||...:.:.||
  Fly  1137 APMSPASSPFRSNSISLSLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTS 1201

Human  1326 SFSASLDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSMEVS 1390
            :.:|.      :.|.::|            .|| :.|:..|                  :|....
  Fly  1202 TVTAP------TVTASAP------------APA-VATVTAP------------------SSAPAP 1229

Human  1391 DLRSKSFDCGSITPP----QTTPLTELQPPSSPSR----VGVTG-HVP---LLERRRGPLVRQIS 1443
            .:.:..|....:..|    ..|||.:....|:|.:    |.:|. |..   ::|.:....::...
  Fly  1230 QIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSD 1294

Human  1444 LNIAPDSHLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAETS--- 1505
            |.:|..|.    .||||                        .||.|..:|...|.:||:...   
  Fly  1295 LVVASSSQ----QPTSF------------------------NFSFNNQNSSNSVPELQSSKEERL 1331

Human  1506 ---NSSSTNVFPVQQLCDI-NLLNQIHAP----PSHQSTQLSLQVSTQGSKPDKN--SVLSGSSK 1560
               .||..::.|:.:..|: |....|..|    .|.|...:.:...|..|..::.  :::|||..
  Fly  1332 RRFTSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGL 1396

Human  1561 SEDCFAPKYQLHCQVFTSGPSCSSNPVHSLPNQVISD---PVGTDHCVTSATLPTKLIDSMSNSH 1622
            ......|:   |.|........:.||: :||.....|   ||.....|.....|..|...|    
  Fly  1397 LGVSSGPQ---HFQFPPINSITAFNPL-TLPPMSGGDKTTPVTPIPHVPGMPGPGSLTPQM---- 1453

Human  1623 PLLPPELRPLGSQVQKVPSSFMLPI---RLQSSVPAYCFATLTSLPQILVTQDLPNQPICQTNHS 1684
            |||||.           |....|||   |.:|                      ||:        
  Fly  1454 PLLPPP-----------PQQLQLPIPSSRGRS----------------------PNR-------- 1477

Human  1685 VVPISEEQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPITQKISVGRLSPQQES 1749
                  :|.| |.|..|....|.........:||.||.|:.       |.|   ...|.:.|..|
  Fly  1478 ------KQPS-PLLLGGGSGELKALSPFGGVQNVPSEFSRQ-------PPT---PAQRQALQWNS 1525

Human  1750 SASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALSSRVNEASKQKKPILVRQVCTT 1814
            ..:.|:  :|.|.|.:|          :|......:||....  ..|....:|:.|:....|.|.
  Fly  1526 KEAPKK--APFNFLRMA----------DNVKTTEPEVRHFNL--ENVISGKQQELPLTPLHVDTP 1576

Human  1815 EPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTGCSKFVVIEPISELQEFENIKSSTSLTLT 1879
            ..           :.||.::..        |..|::..|||  :.|             |||.| 
  Fly  1577 NG-----------NAPEETSPV--------ASASASAKSKF--LRP-------------TSLPL- 1606

Human  1880 VRSSP---APSENTHISPLKCTDNNQERKSPGVKNQGDKVNIQEQSQQPVTSLSLFNI-KDTQQL 1940
               .|   .|..:..|:|   |.|.....||               :.|..|.|...: .:....
  Fly  1607 ---KPGTFTPKRHHGITP---TANTLPLISP---------------ETPRPSKSCVQLYLNGHAY 1650

Human  1941 AFPSLKTTTNFTWCYLLRQKSLHLPQKD-----QKTSAYTDWTVSASN-PNPLGLPTKVALALLN 1999
            .:..||.:|...:|      :::.||..     .|.|.|:.|.|...| |:|||...|..:||.:
  Fly  1651 TYLGLKCSTKMFYC------TVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYD 1709

Human  2000 SKQ------------NTGKSLYCQAITTHSKSDLLVYSSKWKSSLSKRALGNQKS----TVVEFS 2048
            |:|            .:||..|     ....|..:|.|....|:.|....|..|:    |:...|
  Fly  1710 SRQRMLGNGSSTAMAGSGKLSY-----NLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTIAALS 1769

Human  2049 NKD-ASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSML 2112
            ..: |::.|.|...:.  :::.|....:. |||:|:|:|.|:||||||:|:|.||||||||||||
  Fly  1770 EANVAAKANEEAQAKK--LETSPSGQPLV-GGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSML 1831

Human  2113 KKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRF 2177
            ||||||||||||:.|::|||||||||||||||:||.|.|||::||::.|.: ..|:|..|....|
  Fly  1832 KKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPM-PPDSEFLDVDMDF 1895

Human  2178 SYE-------RSGYDLEESDGPDEDDNENEDDDEDS----QAES-------VLSATPSVTASPQH 2224
            ..:       |:.....|||..|..|||:|..|.|.    |.|.       .||.||.:   ||.
  Fly  1896 DQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARGLLSLSMTPPI---PQS 1957

Human  2225 LPSRSSLQDPVSTDEDVRITDCFSGVHTDPMDVLPRALLTRMTVLSTAQSDYNRKTLSPGKARQR 2289
            :.....|||                              |.:...|.|.|     ..|.|...:|
  Fly  1958 VSPYPQLQD------------------------------TPLPAASPANS-----IGSSGSQPKR 1987

Human  2290 AARDENDTIPSVDTSRSPCH---------QMSVDYPESEEILRSSMAGKAVAITQSPSSVRLPPA 2345
            .........|..|..:...:         :.||...||..:..:...|..:.|:.||.||   ||
  Fly  1988 LVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSV---PA 2049

Human  2346 AAEHSPQTAAGMPSVASPHPDPQEQKQQITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVPV 2410
                              |..|:.|.||:           |..:|.    .|..:|.....::.|
  Fly  2050 ------------------HDLPKSQAQQM-----------HDVIFG----TSGNESGFMKTLISV 2081

Human  2411 GGIHVVPAGL----------------TYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSG 2459
            .....:.|.:                ||.....|....::.:..:.|.:..||.|..:.|...|.
  Fly  2082 SDKVRISAEMEEQAKHEAEGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSS 2146

Human  2460 TTNPAGVAELSSV--VPCIPIGQIRVPGLQNLSTPG---------LQSLPSLSMETVNIVGLANT 2513
            |...|....:.||  ||.|.:.:::.|  :.:.:|.         |..:.....|..||....|.
  Fly  2147 TLFTANSRPVMSVNEVPSIEVHEVKTP--EAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNA 2209

Human  2514 NM-----APQVH-----------PPGLALNAVGLQVLTANPSSQSS------PAPQAHIPGLQIL 2556
            |:     .|.|:           ||..::.|..:...||.|.:.||      ||.:..|.|....
  Fly  2210 NLPAAVQQPDVNEFTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGF 2274

Human  2557 NIALPTLIPSVSQVAVDAQGAPEMPASQ---------SKA---------------------CE-- 2589
            ..:.||......|.....:|.|..|.:.         ||.                     ||  
  Fly  2275 KSSTPTSKSGDLQHVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPC 2339

Human  2590 ---------TQPKQTSVASANQVSRTESPQGLPT------------------------------- 2614
                     .|..:.|.|..|:|..| |..|:||                               
  Fly  2340 SISFRTQGHLQKHERSEAHKNKVMMT-STFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLRSKTH 2403

Human  2615 VQRENAKKVLNPPAPAGDHARLD----GLSKMDTEKAASANHVKPKPELTSIQ--GQPASTSQPL 2673
            ||:....:.|    |.|.:|.::    .|:::||....::        |.|::  .|......| 
  Fly  2404 VQKLECLQKL----PFGTYAEIERAGISLTEIDTSDCENS--------LISLKLLAQKLQEKDP- 2455

Human  2674 LKAHSEVFTKPSGQQTLSPDRQVP 2697
              .....:|.|||...|:.|...|
  Fly  2456 --GKLSSYTTPSGMMQLAQDAAGP 2477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HIVEP1XP_011512848.1 C2H2 Zn finger 417..437 CDD:275368 15/19 (79%)
zf-H2C2_2 430..454 CDD:290200 17/23 (74%)
C2H2 Zn finger 445..465 CDD:275368 14/19 (74%)
zf-C2H2 2097..2119 CDD:278523 19/21 (90%)
C2H2 Zn finger 2099..2119 CDD:275370 18/19 (95%)
zf-H2C2_2 2111..2136 CDD:290200 20/24 (83%)
zf-C2H2_2 <2125..2190 CDD:289522 31/71 (44%)
C2H2 Zn finger 2127..2145 CDD:275370 15/17 (88%)
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 15/19 (79%)
zf-H2C2_2 499..523 CDD:290200 17/23 (74%)
C2H2 Zn finger 514..536 CDD:275368 15/21 (71%)
zf-C2H2 1816..1838 CDD:278523 19/21 (90%)
C2H2 Zn finger 1818..1838 CDD:275370 18/19 (95%)
zf-H2C2_2 1830..1855 CDD:290200 20/24 (83%)
zf-C2H2 1844..1868 CDD:278523 18/23 (78%)
C2H2 Zn finger 1846..1868 CDD:275370 18/21 (86%)
zf-C2H2 2307..2328 CDD:278523 2/20 (10%)
C2H2 Zn finger 2308..2328 CDD:275368 2/19 (11%)
zf-C2H2_jaz 2333..2359 CDD:288983 5/25 (20%)
C2H2 Zn finger 2336..2358 CDD:275368 4/21 (19%)
C2H2 Zn finger 2381..2403 CDD:275368 0/21 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4892
eggNOG 1 0.900 - - E33208_3BEXG
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 352 1.000 Inparanoid score I2266
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41578
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45944
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3898
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
88.040

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