DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp354c and CG6654

DIOPT Version :9

Sequence 1:	NP_038950.3	Gene:	Zfp354c / 30944	MGIID:	1353621	Length:	560	Species:	Mus musculus
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	117/362 - (32%)
Similarity:	169/362 - (46%)	Gaps:	50/362 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse   134 RDIAQEQEKKVHGPGAESPKETTSE-----DGTPTGFEPEKPLFISKALVSQEGDPTESVPATYH 193
            |.::..:...|:||...|...||.|     |....||..||.|.|                   |
  Fly   302 RKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMI-------------------H 347

Mouse   194 TSEKDLPQDFDLMRSFQMYPGQKPHVCSECGKGFTQSLHLLEHKRLHTGEKPYKCSECGKSFSHR 258
            ..:|..     :.|:::         |:||.|.|....||.||:..|..   :.|.|||.....:
  Fly   348 RRQKGC-----INRNYK---------CNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSK 395

Mouse   259 SSLLAHQ-RTHTGEKPYKCSECEKAFGSSSTLIKHLRVHTGEKPYRCRQCGKAFSQCSTLTVHQR 322
            .:|..|. :.|......:|:.|:|.|...|||..|:|:||||||:.|..|||:|:|.:.|..|:.
  Fly   396 EALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKL 460

Mouse   323 IHTGEKLYKCAECDKAFNCRAKLHRHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTGEQLCQ 387
            .|:..|.:||..|..:|..:|:|..|.|.|||:||::|..|...::...|||:|:|.||||:...
  Fly   461 RHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYA 525

Mouse   388 CLQCGRTFTRVSTLIEHQRIHTGQKPYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEECGKAFG 452
            |..|...||.::.|..|:|.|||::||.|..|.|||.|......|::.|.||::|.|..|.:.|.
  Fly   526 CDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFK 590

Mouse   453 CKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHE 489
            ....:..|...|        .|..|....::||:..|
  Fly   591 SMPEMRSHLAGH--------EQHDKRLVHFTFLSNKE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp354c	NP_038950.3	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..168		10/33 (30%)
		COG5048	204..>543	CDD:227381	100/287 (35%)
		C2H2 Zn finger	220..240	CDD:275368	9/19 (47%)
		zf-H2C2_2	232..257	CDD:290200	9/24 (38%)
		C2H2 Zn finger	248..268	CDD:275368	6/20 (30%)
		zf-H2C2_2	260..283	CDD:290200	6/23 (26%)
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	289..313	CDD:290200	14/23 (61%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-H2C2_2	317..341	CDD:290200	8/23 (35%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	347..369	CDD:290200	9/21 (43%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..425	CDD:290200	13/23 (57%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..451	CDD:290200	7/22 (32%)
		C2H2 Zn finger	444..464	CDD:275368	4/19 (21%)
		zf-H2C2_2	456..481	CDD:290200	4/24 (17%)
		C2H2 Zn finger	472..492	CDD:275368	5/18 (28%)
		zf-H2C2_2	485..509	CDD:290200	2/5 (40%)
		C2H2 Zn finger	500..520	CDD:275368
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/46 (20%)
		COG5048	<357..570	CDD:227381	84/224 (38%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000