Protein Alignment HHEX and HHEX

DIOPT Version :10

• Sequence 1: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Alignment Length: 314
• Identity: 95/314 - (30%)
• Similarity: 120/314 - (38%)
• Gaps: 110/314 - (35%)

Human     9 AAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPA--------------APTPA---PTLPSPNS 56
            |:.|.|....||||  .|:..|..|  |:.....|              |||..   |..|.|.|
  Fly    55 ASLATGSSSAAPTP--SPSSATNIY--DLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPAS 115

Human    57 SFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAA-----------YGP-----GGFGGP------ 99
            .|...|...:.   .|:...|   |..|||:|||           |.|     .||..|
  Fly   116 LFYQQVLQLQK---NPSLFMP---HFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAA 174

Human   100 LYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSP 164
            ||     .|.|..|.......|.             ||||||:||::.||..||.:|.:.|||||
  Fly   175 LY-----CNAYPAASFYMSNFGV-------------KRKGGQIRFTSQQTKNLEARFASSKYLSP 221

Human   165 PERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQE----------------NPQSNKKEELESLD- 212
            .||:.||..|:|::||||||||||||||||....                :|.|.....:..|:
  Fly   222 EERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNL 286

Human   213 ---SSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGD 263
               |.|.|:.|                      :|| ...:|||.:.:.:.||:
  Fly   287 GSGSRCGQQSD----------------------EED-RMYLSEDDEDDDEDEGE 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		41/166 (25%)
		Homeodomain	136..194	CDD:459649	38/57 (67%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		53/147 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		15/90 (17%)
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	30/66 (45%)