Protein Alignment HHEX and hhex

DIOPT Version :10

• Sequence 1: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_571009.1
• Gene: hhex / 30098
• ZFINID: ZDB-GENE-980526-299
• Length: 228
• Species: Danio rerio
• Alignment Length: 271
• Identity: 165/271 - (60%)
• Similarity: 185/271 - (68%)
• Gaps: 50/271 - (18%)

Human     1 MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGR-----GPAAPTPAPTLPSPNSSFTS 60
            ||:.||       ..|||||.| ..|||||||||||||||     ||..||  ||||||||||||
Zfish     1 MQFQHP-------HAPLYAPAP-APPAHPTPFYIEDILGRTGSSSGPVVPT--PTLPSPNSSFTS 55

Human    61 LVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLL 125
            |:..||||:||.|||||..|.:::               :|||.|:|.|:.|||:||||||||||
Zfish    56 LIPSYRTPIYELTPIHPVLSQYAS---------------MYPFQRSVGDFAHALIRHDPLGKPLL 105

Human   126 WSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRA 190
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   106 WSPFIQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRA 170

Human   191 KWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSD 255
            ||||||||||.|..|.|.|  ||                  |:.:.|.:.|...:|||..|.||:
Zfish   171 KWRRLKQENPPSTGKREAE--DS------------------DTRRLSDAAARARELESGASTDSE 215

Human   256 QEVDIEGDKSY 266
            :.:|||.:..:
Zfish   216 ELLDIEDEHQF 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		82/140 (59%)
		Homeodomain	136..194	CDD:459649	57/57 (100%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		82/130 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		25/73 (34%)
hhex	NP_571009.1	Homeodomain	122..174	CDD:459649	51/51 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..228		24/72 (33%)