Protein Alignment Ap2a1 and AP-2alpha

DIOPT Version :9

• Sequence 1: NP_001382021.1
• Gene: Ap2a1 / 308578
• RGDID: 1306254
• Length: 977
• Species: Rattus norvegicus
• Sequence 2: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 965
• Identity: 632/965 - (65%)
• Similarity: 740/965 - (76%)
• Gaps: 56/965 - (5%)

  Rat    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 87
            |||||||:||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||
  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98

  Rat    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIP 152
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.||||:|||:|.|:|:.:||
  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163

  Rat   153 RILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKK 217
            ::||:||:||.||||||||||||:::|||::|.||||:|::||||||||||||||.|||..|.|:
  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228

  Rat   218 NPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCY-PPPEDAAVKGRLV 281
            |||::|.||:||||||||||:::.|||||||||||||||||||||||||.| |..|:|.|:.||.
  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293

  Rat   282 ECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLR 346
            |.|||:|||||||||||||||||||||:|||.|:||||.||||||||||||||||||.:||||||
  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358

  Rat   347 YLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLR 411
            ||||||||.||:||||||.||.|.:.||.::|.|:||||||.|.|||||||||.||::||.|||.
  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423

  Rat   412 YLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQ 476
            |||||||:||||:||||||||||||.||:||||.||||||||||||||||||||:|||.||::||
  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488

  Rat   477 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALL 541
            ||||||||||||||||||||||||||||||||||||||.||:|.|||.|||||:||||..|||||
  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553

  Rat   542 LSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFP 606
            |||||||||||||.:..||.|.|..|.||:||.||||||.|||.||.|||||||||||||||.||
  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618

  Rat   607 ERESSILAKLKRKKGPGAA--SALDDSRRD---TSSNDINGGVEPTPSNVSTPSPSADLLGLRAA 666
            ||||||||.||:|| ||..  :.:.:|:..   ||:...|..|..:.|.::..:.:.|||||...
  Fly   619 ERESSILAVLKKKK-PGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTP 682

  Rat   667 PPPAAPPAPVGGNLLVDVFSD--GPTAQPSLGPTPEEAFLSELEPPAPESPMTLLADPAPAADPG 729
            |...........:.|:||..|  |..:..:
  Fly   683 PSNNIGSGSNSNSTLIDVLGDMYGSNSNNN----------------------------------- 712

  Rat   730 PEDIGPPIPEADELLN--KFVCKNSGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQSFL 792
                      :..:.|  ||:.||:||||||::|||||||||||||||:.|||||||.|...:|.
  Fly   713 ----------SSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN 767

  Rat   793 PTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGTAQSLTLKL 857
            |.:....:...:|.||.|.|...::.|||:||:|..||:.|:...|.:.:.|||.||.|..::||
  Fly   768 PVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKL 832

  Rat   858 PVTINKFFQPTEMAAQDFFQRWKQLSLPLQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPN 922
            |:::||||:||||.|:.||.|||.||...|.:||:|||..|:|....:.||:|||..|||.||||
  Fly   833 PLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPN 897

  Rat   923 PENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCELLAQQF 977
            |:|.|.||||.|::.|||||:|||||.||||:|||:|.|||.|:|.:|:||..||
  Fly   898 PDNMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRLTVRASKETVTREICDLLTDQF 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ap2a1	NP_001382021.1	None
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	444/557 (80%)
		Alpha_adaptinC2	730..839	CDD:197886	54/108 (50%)
		Alpha_adaptin_C	839..947	CDD:280460	66/107 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349231
Domainoid	1	1.000	898	1.000	Domainoid score	I46
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1290	1.000	Inparanoid score	I148
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D751651at2759
OrthoFinder	1	1.000	-	-		FOG0002465
OrthoInspector	1	1.000	-	-		otm46233
orthoMCL	1	0.900	-	-		OOG6_101447
Panther	1	1.100	-	-	O	PTHR22780
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1882
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910