DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh14 and Mhc

DIOPT Version :9

Sequence 1:XP_038967907.1 Gene:Myh14 / 308572 RGDID:1306821 Length:2041 Species:Rattus norvegicus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2069 Identity:759/2069 - (36%)
Similarity:1175/2069 - (56%) Gaps:155/2069 - (7%)


- Green bases have known domain annotations that are detailed below.


  Rat    17 PGPV----PEAAQPFLFA---PRTPNVGGPGGPQVEWTARRMVWVPSELHGFEAAALRDEGEEEA 74
            |.||    .|...|:||.   .|..:...|      :.:::..|:|.|..|:....::....:..
  Fly     2 PKPVANQEDEDPTPYLFVSLEQRRIDQSKP------YDSKKSCWIPDEKEGYLLGEIKATKGDIV 60

  Rat    75 EVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCV 139
            .|.| :.|....:..::::::|||||.|.||||::|.||...||||||:|||:.|||||||||||
  Fly    61 SVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCV 124

  Rat   140 VINPYKQLPIYTEAIVEMYRGKKRHEVPPHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENT 204
            .|||||:.|:||....:|||||:|:||||||:|:::|||..||.:..:||:|.||||||||||||
  Fly   125 AINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENT 189

  Rat   205 KKVIQYLAHVASSPKGRKEPGVPASVSTMSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKF 269
            ||||.|.|.|.:|.|        ...:..|.|.||.|::|.||:||||||||||:||||||||||
  Fly   190 KKVIAYFATVGASKK--------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKF 246

  Rat   270 IRINFDIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLK-ADLLLEPYSHYRF 333
            |||:|...|.:.||:||||||||:|.|.|...|.|:|||||::.|:...:| ..||.:....|..
  Fly   247 IRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHI 311

  Rat   334 LTNGPSSSPG-QERELFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPD 397
            ::.|..:... .:.|.|..|.::..:||...:|...:.|..:||:..|.:..|:....:||....
  Fly   312 VSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDG 376

  Rat   398 NTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLR 462
            .....::.:|.|....:..:.||.||||||.::|.:.:..:|...::.||.|..::|||:|||.:
  Fly   377 EEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKK 441

  Rat   463 LNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGI 527
            .|..||...:: ..|:|:|||||||||:.|.|||||||:|||||||.|||.|||||||||:||||
  Fly   442 CNETLDTQQKR-QHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGI 505

  Rat   528 PWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQ-GSHPKFQRPRN 591
            .|.|:|||:||..||||||:|.   |:|::|:||..||||||::|.||:.... |....||:|:.
  Fly   506 DWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKP 567

  Rat   592 LR---DQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDEQGGLQQFT 653
            .:   ..|.|::.||||.|.|....||.||.|||||.|.....:|.::|..||:.|.        
  Fly   568 PKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADH-------- 624

  Rat   654 FLGSFPSPSPGPAGGLSSGASPPGLGSLCAPTVEGIVGLEQVSSLGDGPPGGRPRR-GMFRTVGQ 717
                     .|.:||                              |:...|||.:: |.|.||..
  Fly   625 ---------AGQSGG------------------------------GEQAKGGRGKKGGGFATVSS 650

  Rat   718 LYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRIL 782
            .|||.|:.||.||.:|.|.|||||:||..|:.|.::..||:.||.||||||||||||:|||||::
  Fly   651 AYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMM 715

  Rat   783 FQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLK 847
            :.:|:.||:|:.|..: :|....|:|.|.:|:.::|..:.||:|.:|:|||||||.|:||.||.:
  Fly   716 YPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDER 779

  Rat   848 VTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTR- 911
            :..|:...||.|||||:|:.|::.|:|:.||:|:|||...||:||.|.|::|:.||||||.|:| 
  Fly   780 LGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRI 844

  Rat   912 QDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCSEAEETRARL 975
            :||:  ||.:| .:|.:||.....:...||:...|:|..|:..|.:.|..|.....:.:|..|:|
  Fly   845 EDEI--ARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKL 907

  Rat   976 AARKQELELVVTELEARVGEEEECSRQLQSEKKRLQQHIQELETHLEAEEGARQKLQLEKVTTEA 1040
            .|:|.:||..:.:::.|:.:||:...||..:||:..|.|..|:..:|..|...||.:.:|.|.:.
  Fly   908 TAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDH 972

  Rat  1041 KMKKFEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAEEEEKVKSLNKLRVKYEATIADMEDRL 1105
            :::...:::...::..:||:||:::..|...:...:....|:|:..|||::.|.|.|:.::||.|
  Fly   973 QIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSL 1037

  Rat  1106 KKEEKGRQELEKLKRRLDGESSELQEQMMEQKQRAEELLIQLGRKEEELQSALVRAEEEGGARAQ 1170
            ::|:|.|.::||.||:::|:....||.:.:.::..:||...:.||::||.|...:.|:|.....:
  Fly  1038 EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLK 1102

  Rat  1171 LLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1235
            ..:.::|.||.:.|.:|::||||.|||||||||.||..|||.|...||:...:|:||.||..|||
  Fly  1103 HQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKRE 1167

  Rat  1236 QEVTELKKTLEEEARTHEVAMQELRQRHSQALVELTEQLEQARRGKSVWEKTRLSLEAEVSELKT 1300
            .|:::|::.|||....||..:..||::|:.|:.|:.||::|..:.|:..||.:.....::::|:.
  Fly  1168 AELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRA 1232

  Rat  1301 ELSSLQTSRQEGEQKRRRLESQLQEVQGRSSDSERARAEAAEKLQRAQVELESVSTALSEAESKA 1365
            .:..:...:...|:..::|:..|.|||.:..::.|...:.....::..:|...:...|.||||:.
  Fly  1233 GVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQV 1297

  Rat  1366 IRLSKELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLREQMEEEVVARERAGRELQT 1430
            .:|||...|..:||.||:.|..||:|.:..|..:.|.||.:...||||:|||...:....|:|..
  Fly  1298 SQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSK 1362

  Rat  1431 TQAQLSEWRRRQEEE-AAVLEAGEEARRRAAREAETLAQRLAEKTEAVER-------LERARRRL 1487
            ..|:...||.:.|.: .|..|..|||:|:       |..||||..|.:|.       ||:.::||
  Fly  1363 ANAEAQVWRSKYESDGVARSEELEEAKRK-------LQARLAEAEETIESLNQKCIGLEKTKQRL 1420

  Rat  1488 QQELDDATVDLGQQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERVEAEGREREARALS--- 1549
            ..|::|..:::.:...:.:..||||:.||:::.|.|..|     |....|.:..::|.|..|   
  Fly  1421 STEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKV-----DDLAAELDASQKECRNYSTEL 1480

  Rat  1550 --LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKNVHELERARRVAEQAASDLRTQVTE 1612
              |..|.||.||..|.:.|:|:.|..|::.||....:.|:|:||:|:||:..|....:|:..:.|
  Fly  1481 FRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEE 1545

  Rat  1613 LEDELTAAEDAKLRLEVTVQALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEERKQRALA 1677
            .|..|...|:..||.::.:..::.:.:|.:|.:::..|..|:...:.|...:...:.|.|.:|.|
  Fly  1546 AEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEA 1610

  Rat  1678 MAARKKLELELEELKAQTSAAGQGKEEAVKQLKKMQAQMKELWREVEETRSSREEMFTLSRE--- 1739
            :..:||||.::.||:.....|.:...||.|.:|:.|.|:|::...:||.:.:|::    :||   
  Fly  1611 LRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDD----AREQLG 1671

  Rat  1740 -SEKRLKGLEAEVLRLQEELAASDRARRQAQQ---DRDEMAEEVASGNLSKAATLEEKRQLEGRL 1800
             ||:|...|:.|:...:..|..:||.||||:|   |..|...||::.|.|.:|.   ||:||..|
  Fly  1672 ISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAA---KRKLESEL 1733

  Rat  1801 GQLEEELEEEQNNSELLKDHYRKLVLQVETLTTELSAERSFSAKAESGRQQLERQIQELRARLGE 1865
            ..|..:|:|..|.::..::..:|.::....|..||.||:..:...|..|:.||:||:||:.||.|
  Fly  1734 QTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDE 1798

  Rat  1866 EDAGARARQKMLIAALESKLAQAEEQLEQESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQL 1930
            .:|.|....|..|..||.::.:.|.:|:.|.|....:.|.:|::|:|:||:..|.:|:|:..:::
  Fly  1799 AEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERM 1863

  Rat  1931 RDQLEKSNLRLKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPL 1995
            :|.::|...::|..|||:|||||.|:...|..|:.|:|||:..|.|:...:.::..|.:.|.|.:
  Fly  1864 QDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSV 1928

  Rat  1996 TFTTRTVRQVFRLEEGVASDEEEAEGAEPGSAPTQ-EPE----APPP---AAPQ 2041
                                   ..||.|....|. .|:    |.||   .||:
  Fly  1929 -----------------------GRGASPAPRATSVRPQFDGLAFPPRFDLAPE 1959

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh14XP_038967907.1 Motor_domain 115..833 CDD:419868 330/724 (46%)
Myosin_tail_1 910..1990 CDD:396244 345/1101 (31%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 7/37 (19%)
MYSc 81..777 CDD:214580 352/755 (47%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 330/724 (46%)
Myosin_tail_1 842..1897 CDD:279860 337/1075 (31%)
V_Alix_like 1557..1877 CDD:187408 98/326 (30%)
ATP-synt_B <1671..1771 CDD:304375 33/102 (32%)
TMPIT 1739..>1825 CDD:285135 27/85 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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