DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2b and Kdm2

DIOPT Version :9

Sequence 1:	XP_011246510.1	Gene:	Kdm2b / 30841	MGIID:	1354737	Length:	1312	Species:	Mus musculus
Sequence 2:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster

Alignment Length:	1533	Identity:	478/1533 - (31%)
Similarity:	654/1533 - (42%)	Gaps:	513/1533 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 RRLR-AIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLY-QGDFVHAMEGKDFNYEYVQREAL 71
            |:|| ...|:.|.|...|.| |:....||||:.|||.|..: |...|..|.|.|....::|:...
  Fly    42 RQLRERKQRKLYLEEWSLGD-EDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLTVAFLQQHGF 105

Mouse    72 RVPLVFRDKDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQ 135
            .:||:||||.|||::|||| :|||.||:|.||||||:|||||||||..:|:|.::.:||::|  |
  Fly   106 NIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSP--Q 168

Mouse   136 RDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCL 200
            :|:|.||||||||||:|:..|:.|.:|..:||||.:||:.||:.|.|.||.|..|.||||:||||
  Fly   169 KDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCL 233

Mouse   201 MSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQ 265
            ||||.|:|||||||||||||||:.||.|:|||||||..||.|||:|||||||:|||.||.||:|.
  Fly   234 MSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCA 298

Mouse   266 RIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYE 330
            |:.|..|.|||||:|||||||||..|||||||.||||.:..||:...:||.|:|..||||||:.|
  Fly   299 RVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTE 363

Mouse   331 MCWYVLERYVYCVTQRSYLTQEYQRELMLIDAPRKTSVDGFSSDSWLDMEEESCEQQPQEEEEEE 395
            |.||||.|||:.:...|:|
  Fly   364 MLWYVLARYVHTLLGHSHL---------------------------------------------- 382

Mouse   396 EDKEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPKAPAIRFLKRTLSNESEESVKSTSMP 460
                 ||:.:                   ..:|....:|.
  Fly   383 -----EGEAS-------------------LSEDEMAARPH------------------------- 398

Mouse   461 TDDPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVL 525
                               ||||..||.|||.:|..|..||..||.||..:.||.||::.|::::
  Fly   399 -------------------THLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLV 444

Mouse   526 KEHVDDDPTLAITGVPVVSWP-------------------------------------------- 546
            :.|..|...||||||.|:..|
  Fly   445 ERHCKDQQDLAITGVSVLKSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRARE 509

Mouse   547 ------KKTAKNRVVG---------------------------------------------RPKG 560
                  :.|....|:|                                             ||..
  Fly   510 AESDTSQSTGVGSVIGMGAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPK 574

Mouse   561 KL------------------GPASAV--------------------------------------- 568
            |:                  ||.:.|
  Fly   575 KMHLATALVAAAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEG 639

Mouse   569 --------------------KLAANRTTAG-ARRRRTRCRKCEACLRTECGECHFCKDMKKFGGP 612
                                ||:.|.|..| .|||||||:.|.||.|::||.|.||.||.|||||
  Fly   640 GQVGGILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGP 704

Mouse   613 GRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNL-------MLMECSICNEIIHP 670
            ||.||:|:||||::|:||.||.|:.|...|...|....:.| .|       .|||||:|.||.||
  Fly   705 GRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTK-QLASADGPSALMECSVCYEIAHP 768

Mouse   671 GCL--------KIKESEGVVNDELPNCWECPKCNHAGKTGKAYKQKRGPGFKYASNLPGSLLKEQ 727
            .|.        ...:::|:||::|||.||||.|..:||
  Fly   769 DCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGK--------------------------- 806

Mouse   728 KMNRDNKEGQEPAKRRSECEEAPRRRSDEHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGRK 792
              |.|.|                       |:...|    |:||.:|                 :
  Fly   807 --NYDYK-----------------------PRHFRA----RQKSSEV-----------------R 825

Mouse   793 RASSLQTSPGSSSH-----LSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAE 852
            |.|......|:..|     |.| ||:|.     :...:...:.:::.|    ........||:.
  Fly   826 RVSVSHGQGGAEGHADGNTLLP-PPVGQ-----YNDFVFTSESEMESG----TVSGHMTHWKHG- 879

Mouse   853 DRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL 917
                     ::|..|        ...||..::...:.||...|:..|.:     .||..|||
  Fly   880 ---------MKRHHQ--------LEVKTERNNSCDTPSPGISPNAIGGD-----SKVGKRRK--- 919

Mouse   918 VNKELSKELSKELNHEIQKTESTLAHESQQ-PIKSEPESENDEPKRPLSHCERPHRFS-KGLNGT 980
                          .:...:.|:..|||.. |..|..|.........:|    .:::| .|..|.
  Fly   920 --------------SDDGTSVSSSMHESNDAPCGSSAEGAGGAGNANVS----TNQWSGSGGGGG 966

Mouse   981 PRE---LRHSLGPG-LRSPPRVMSRPPPSASPPKCIQMERHVIRPPPISPPPDS----------- 1030
            .|:   :|..|... |.|..||:.:|             ::|:||...:....|
  Fly   967 SRKKNSIRSQLAQQMLNSSTRVLKKP-------------QYVVRPASGTGSSSSSGNGGSASATN 1018

Mouse  1031 ---------------------------LPLDDGAAH---------VMHREVWMAVFSYLSHRDLC 1059
                                       |...:|..:         .:...|...:|.||....|.
  Fly  1019 GISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLV 1083

Mouse  1060 VCMRVCRTWNRWCCDKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRL 1124
            .|..||:.|:....|..||.:::.:..| ::..:|:.|:||||..|.|.||.|:|:||:||:.||
  Fly  1084 TCCSVCKVWSNAAVDPDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARL 1147

Mouse  1125 PGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLR 1189
            |.|::|.|..|...||.||.:..||.|:|||:.:|.||.||.:||:||||.|:|||..|::::||
  Fly  1148 PALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLR 1212

Mouse  1190 NIVELRLAGLDITDVSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAVGTTTRDS--LTEVNLS 1252
            ::..::|||.||:||::|.|.:.:|.|..|.||.|..|.|..:   ..:||:|..:  |||:|||
  Fly  1213 DLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGV---AQIGTSTTATARLTELNLS 1274

Mouse  1253 DCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQF 1290
            .|..|::..|....:|..:..:|||:..||:.:...:|
  Fly  1275 ACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRF 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2b	XP_011246510.1	JmjC	151..226	CDD:214721	46/74 (62%)
		cupin_like	198..297	CDD:389752	75/98 (77%)
		JHD	303..>338	CDD:375347	18/34 (53%)
		zf-CXXC	<588..624	CDD:366873	23/35 (66%)
		PHD_KDM2B	634..695	CDD:277114	27/75 (36%)
		PTZ00449	<693..995	CDD:185628	53/312 (17%)
		F-box-like	1044..1082	CDD:372399	12/37 (32%)
		leucine-rich repeat	1053..1075	CDD:275381	6/21 (29%)
		leucine-rich repeat	1078..1102	CDD:275381	6/23 (26%)
		AMN1	1083..1283	CDD:187754	86/201 (43%)
		leucine-rich repeat	1103..1126	CDD:275381	12/22 (55%)
		leucine-rich repeat	1127..1150	CDD:275381	9/22 (41%)
		leucine-rich repeat	1151..1190	CDD:275381	21/38 (55%)
		leucine-rich repeat	1191..1215	CDD:275381	9/23 (39%)
		leucine-rich repeat	1216..1245	CDD:275381	10/28 (36%)
		leucine-rich repeat	1246..1270	CDD:275381	10/23 (43%)
		leucine-rich repeat	1271..1295	CDD:275381	6/20 (30%)
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	76/99 (77%)
		PRTases_typeI	<394..>467	CDD:294217	33/116 (28%)
		zf-CXXC	670..716	CDD:251032	30/45 (67%)
		PHD_4	721..801	CDD:293471	31/80 (39%)
		F-box-like	<1073..1108	CDD:289689	11/34 (32%)
		leucine-rich repeat	1102..1125	CDD:275381	6/23 (26%)
		leucine-rich repeat	1126..1149	CDD:275381	12/22 (55%)
		leucine-rich repeat	1150..1173	CDD:275381	9/22 (41%)
		AMN1	1166..>1320	CDD:187754	61/150 (41%)
		leucine-rich repeat	1174..1213	CDD:275381	21/38 (55%)
		leucine-rich repeat	1214..1238	CDD:275381	9/23 (39%)
		leucine-rich repeat	1239..1267	CDD:275381	10/30 (33%)
		leucine-rich repeat	1268..1292	CDD:275381	10/23 (43%)
		leucine-rich repeat	1293..1317	CDD:275381	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I2020
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	810	1.000	Inparanoid score	I482
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50015
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	1	1.000	-	-		otm43087
orthoMCL	1	0.900	-	-		OOG6_104082
Panther	1	1.100	-	-	O	PTHR23123
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R626
SonicParanoid	1	1.000	-	-		X1005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.950