DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgrg6 and Cubn

DIOPT Version :9

Sequence 1:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	906	Identity:	193/906 - (21%)
Similarity:	312/906 - (34%)	Gaps:	283/906 - (31%)

- Green bases have known domain annotations that are detailed below.

  Rat    41 CRLVLSNPSGTFTSPCYPNDYPNTQSCSWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNG- 104
            |...|....|.|.||.||..|||...|.|.:.......|::|.|:.|:|::|||..|:|::.|.
  Fly  1439 CMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHK 1503

  Rat   105 ---ESQTKFCGATAKGLSFNSSVNEMHVSFSSDFSIQKKGFNASYIRV------AVSLRNQKVIL 160
               |...:.||:|.| |...||.:.:||.|.||.|....||.|:|..|      .::.||..:..
  Fly  1504 NSVEVHERHCGSTTK-LVITSSGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTARNGVIES 1567

  Rat   161 P--------QTLDAYQVSVAKSISI-----------------PELKAFTLCFEASK-------VG 193
            |        .:...:||.|::...|                 ..|:|:.|..:.::       .|
  Fly  1568 PNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDLTEDDTEGERLFKVCG 1632

  Rat   194 NE-DDDWTAFSYSDKSLTQLLSLEKANNGYF-----------------------LSISGAR---C 231
            :| :||....|.|:.::.:.:|.:..:...|                       :|...||   |
  Fly  1633 DETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFHESCGQTIIVDETMFDYIQMSRQAARNESC 1697

  Rat   232 LLNNALPVKEKEDIFTGNFEQL-------------CLVWNNSWGSVGINFKKNYETIPCDLTIGT 283
            |.........|..|||....:|             ||       :||:   |.||        ||
  Fly  1698 LWVFQAVEPNKRIIFTPTHVKLREDANQQYPTEGDCL-------NVGV---KIYE--------GT 1744

  Rat   284 VVPGDGTL---------LLGSDRDEIASLK------------------GSVYNFRLWNFTMD--P 319
            ...|...|         |:.:.:....|:.                  ||:||.....||..  |
  Fly  1745 EPQGTPRLKFCRSHPPALISNGQALTVSVPLQLVEEFQGHYMTMDTSCGSIYNALSGKFTSPYYP 1809

  Rat   320 KSL-SNLSC-----SMSGNVIDWHNDFWSISTQALKAENNLSCG-SYLIPLPAAELTNCSDLGTL 377
            .|. .|:.|     :..||.:       |::.:::..|.:.||. .||      |:...|:.|.|
  Fly  1810 ASYPPNIECLWLLEASMGNSL-------SLTLESMDLEKSESCNRDYL------EVREESESGQL 1861

  Rat   378 CQATVSPPTPPSPIVTTNIPVTNRIRKQKN---DGIMYRISVVIHNDLNHPEVRVQSKVAEWLNA 439
            .........|  .::.:...:..:.:...:   :|.|...:...||:||..|..::|   ....:
  Fly  1862 IGVYCGNEVP--GVIHSRGAIWMKFKSDDDNVGEGFMASYNYEHHNELNGTEGTIES---PHFPS 1921

  Rat   440 TFQ-----NWNYTV---YVVNIS--FHQDLGEDRMK---------VKRDVMDDDKRLVLWALLVY 485
            .||     :|..||   |||.||  :.:||.:..:.         .:.:|.|.|:.::....:||
  Fly  1922 KFQDPVPYSWRITVDKEYVVAISLLYLRDLDQPHLNFYDGYSDIGARIEVTDPDETIISSTNVVY 1986

  Rat   486 NATNN--VSLNGEMIEQKLSANNASLEDGIRLC-----KVDVKQLGMCNTLGDPEGFK------W 537
            ..:|.  ..||...:.::...:|.:.|:..|.|     .:|...:|. ::.|.|.|::      |
  Fly  1987 FTSNRGPFKLNWNRLSKEALRSNRTAEERTRQCGNQLITIDRSVIGF-HSPGYPNGYEQDLNCFW 2050

  Rat   538 TAISPSVYKQPCPNKPGFFMMRT------------CLCNETSTFWGPIDASNCS--RQSNEVANE 588
            |.:         |:.|....:.|            |:.:....|.|. |..|.|  |....:..|
  Fly  2051 TLV---------PSNPAMHAVLTLSQIDLEIFSEDCIADYVKIFSGS-DLQNWSELRTLCSLPTE 2105

  Rat   589 ILDLTGDG------QNLTSANINSIVEQVKRIVNKEENIDRTLGSTLMNIFSNILSSSDSNLLES 647
            ..|....|      :.:|..::|.  .....||......:.|....|:||
  Fly  2106 SSDRVFHGRPYLRVEFVTDPSVNK--TGFNGIVRTACGSEITASKGLVNI--------------- 2153

  Rat   648 STEALKTI----DELAFKIDLNSTPHVNIE------TQNLALGVSS------LMPGTNAPSNF-- 694
             ||.||.:    .:..:.|.:.....:.|:      ..|:|.|.|.      |..|.:..|.|
  Fly  2154 -TEILKVLPRPNHDCVWTIKVRQGRRIKIDFPDFQLQNNMASGSSDCRNYLLLRNGNDEDSPFLG 2217

  Rat   695 ----------SIGLPSNNDSYFQMDFENGQADPLASVILPPNLL-----ENLSPEDSILVR 740
                      .:...|:|.:|.:..|.:           ||..|     |.|...||..:|
  Fly  2218 RGKYCEDVVHEVLNTSSNKAYIKFHFAS-----------PPRFLVSFRFEELRYTDSGRIR 2267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001	41/108 (38%)
		LamG	178..337	CDD:304605	46/240 (19%)
		GPS	799..844	CDD:280071
		7tm_4	861..1108	CDD:304433
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042
		CUB	853..970	CDD:238001
		CUB	978..1094	CDD:238001
		CUB	1100..1211	CDD:238001
		CUB	1216..1330	CDD:238001
		CUB	1446..1549	CDD:238001	40/103 (39%)
		CUB	1554..1667	CDD:238001	18/112 (16%)
		CUB	1792..1899	CDD:238001	25/121 (21%)
		CUB	1910..1998	CDD:294042	21/90 (23%)
		CUB	2019..2133	CDD:238001	23/126 (18%)
		CUB	2140..2242	CDD:238001	21/117 (18%)
		CUB	2263..2379	CDD:238001	2/5 (40%)
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000