DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CXXC1 and cxxc1b

DIOPT Version :9

Sequence 1:	NP_001095124.1	Gene:	CXXC1 / 30827	HGNCID:	24343	Length:	660	Species:	Homo sapiens
Sequence 2:	NP_956627.1	Gene:	cxxc1b / 360150	ZFINID:	ZDB-GENE-030728-4	Length:	563	Species:	Danio rerio

Alignment Length:	660	Identity:	405/660 - (61%)
Similarity:	468/660 - (70%)	Gaps:	97/660 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAI 65
            |:.:.||.: ...|.|:..|.|||||:||||||.||||||||||||||||||.||.:||||||||
Zfish     1 MDSEMSDMD-QTPGLDNSMEKGENAPLYCICRKSDINCFMIGCDNCNEWFHGHCINVTEKMAKAI 64

Human    66 REWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGA 130
            |||||::||.:||.|.|||| ||:|::|      .||  |...::...|:..:.:|.||
Zfish    65 REWYCQQCRARDPSLSIRYR-KKNRDKD------VEP--ERVEKRSSTPEYKIDKRRGS------ 114

Human   131 MLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGG 195
                                          ::|||||||||||.|.|||||||||||:|||||||
Zfish   115 ------------------------------KVKRSARMCGECEPCTRTEDCGHCDFCKDMKKFGG 149

Human   196 PNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGA 260
            |||||||||||||.:|||                                    |:.|:|::|
Zfish   150 PNKIRQKCRLRQCVVRAR------------------------------------KMLRVRDEE-- 176

Human   261 VASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAV 325
              .|..:............||:....|.|||:.     :.|....|.|:.::.....|..||:|:
Zfish   177 --FSLRERKDNIMHRDRRYSDDYDENDMDLYEH-----YKDRNASWGSEDDDGQLYSPVPRKKAI 234

Human   326 KVKHVKRREKKSEKKVMERKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQP 390
            ||||||||:||.:||    ||.|  ||:|||||:|:.:|.:|.|.:......|||||.|:.||:|
Zfish   235 KVKHVKRRDKKFDKK----KESR--RHKQKQKHRDRLRHSDRTDGRHGGDTQQCLGPNCIEPARP 293

Human   391 SSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRF 455
            :|||||:|||||||||||||:|||||||||||||||||.|||.|||||||||:||.||.||||||
Zfish   294 NSKYCSEDCGMKLAANRIYEVLPQRIQQWQQSPCIAEEQGKKQLERIRREQQAARMRLAEMERRF 358

Human   456 HELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFG 520
            ||||.||.:||||.|.:||:.||.||:|||||||||||.||:||:||||||||||||||||||||
Zfish   359 HELEGIIAKAKQQLVLQDEDVNETDSEDTDLQIFCVSCSHPVNPKVALRHMERCYAKYESQTSFG 423

Human   521 SMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCR 585
            |::|||||||||||||||||||||||||||||||||||||||.:||||||||||:||:.|||:||
Zfish   424 SIFPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVTSDEVCGCPLVRNVFDPTGDYCR 488

Human   586 LPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPL 650
            :.||:||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   489 VSKRKCNKHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPL 553

Human   651 TTDLRSSADR 660
            |||||||.||
Zfish   554 TTDLRSSKDR 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CXXC1	NP_001095124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		5/18 (28%)
		PHD_Cfp1	28..73	CDD:277028	39/44 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..162		13/77 (17%)
		zf-CXXC	162..208	CDD:366873	41/45 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..287		7/67 (10%)
		zf-CpG_bind_C	406..640	CDD:403474	202/233 (87%)
cxxc1b	NP_956627.1	PHD_Cfp1	27..72	CDD:277028	39/44 (89%)
		zf-CXXC	115..162	CDD:251032	41/46 (89%)
		zf-CpG_bind_C	309..543	CDD:289071	202/233 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I3754
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32221
Inparanoid	1	1.050	813	1.000	Inparanoid score	I3386
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48041
OrthoDB	1	1.010	-	-		D187233at7742
OrthoFinder	1	1.000	-	-		FOG0003492
OrthoInspector	1	1.000	-	-		otm28035
orthoMCL	1	0.900	-	-		OOG6_107072
Panther	1	1.100	-	-	O	PTHR46174
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1383
SonicParanoid	1	1.000	-	-		X3950
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.370