DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CXXC1 and cfp-1

DIOPT Version :9

Sequence 1:	NP_001095124.1	Gene:	CXXC1 / 30827	HGNCID:	24343	Length:	660	Species:	Homo sapiens
Sequence 2:	NP_001379228.1	Gene:	cfp-1 / 178363	WormBaseID:	WBGene00009924	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	528	Identity:	127/528 - (24%)
Similarity:	207/528 - (39%)	Gaps:	159/528 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   169 CGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLP 233
            |..|..|...::||.|..||:.|          .|.:|:| ..|:..|            :|.:.
Worm    17 CMNCIRCNDEKNCGTCWPCRNGK----------TCDMRKC-FSAKRLY------------NEKVK 58

Human   234 RPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPP-EATATPEPLSDEDLPLDPDLYQDFCAG 297
            |           |..:.|..|      :|.:..:|.. :|..|..|.:
Worm    59 R-----------QTDENLKAI------MAKTAQREAAHQAATTTAPSA----------------- 89

Human   298 AFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKK-------------------SEKKVME 343
                                |.:.::.|:.|  ||..||                   :|:..:.
Worm    90 --------------------PVVIEQQVEKK--KRGRKKGSGNGGAAAAAQQRKANIINERDYVP 132

Human   344 RKEERYK----RHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLA 404
            .:..|.:    |.::.|.:.:..|||.           |||.|.|:..::..||||||:||.:||
Worm   133 NRPTRQQSADLRRKRTQLNAEPDKHPR-----------QCLNPNCIYESRIDSKYCSDECGKELA 186

Human   405 ANRIYEILPQRIQQW-----QQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHE-----LE 459
            ..|:.||||.|.:|:     ...|...|:..|....:|.||.|    :|.|.|:....     :|
Worm   187 RMRLTEILPNRCKQYFFEGPSGGPRSLEDEIKPKRAKINREVQ----KLTESEKNMMAFLNKLVE 247

Human   460 AIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVA-LRHMERCYAKYESQTSFGSMY 523
            .|..:.|.|.:..:|..      |.:|...|:.||.|..|.:. .:|:|.|:|:.|...|||:
Worm   248 FIKTQLKLQPLGTEERY------DDNLYEGCIVCGLPDIPLLKYTKHIELCWARSEKAISFGA-- 304

Human   524 PTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCP------------LVRDV 576
            |.:  .....:|:.|:.::.::||||:.|||||.:.......:|||.|            .|.::
Worm   305 PEK--NNDMFYCEKYDSRTNSFCKRLKSLCPEHRKLGDEQHLKVCGYPKKWEDGMIETAKTVSEL 367

Human   577 FELTGDF----CRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQ--ERNVRTAMTNRAG 635
            .|:...|    ||..|..|::|:.|....|..::||:..::.|:.||..:  :.|.....|..|
Worm   368 IEMEDPFGEEGCRTKKDACHKHHKWIPSLRGTIELEQACLFQKMYELCHEMHKLNAHAEWTTNA- 431

Human   636 LLALMLHQ 643
             |::|:|:
Worm   432 -LSIMMHK 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CXXC1	NP_001095124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHD_Cfp1	28..73	CDD:277028
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..162
		zf-CXXC	162..208	CDD:366873	11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..287		10/68 (15%)
		zf-CpG_bind_C	406..640	CDD:403474	72/262 (27%)
cfp-1	NP_001379228.1	zf-CpG_bind_C	188..435	CDD:403474	72/262 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I5870
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48041
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003492
OrthoInspector	1	1.000	-	-		oto21944
orthoMCL	1	0.900	-	-		OOG6_107072
Panther	1	1.100	-	-	LDO	PTHR46174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.920