DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRE2 and mthl1

DIOPT Version :9

Sequence 1:	XP_011526250.1	Gene:	ADGRE2 / 30817	HGNCID:	3337	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	166/764 - (21%)
Similarity:	252/764 - (32%)	Gaps:	275/764 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   197 PIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCED 261
            |.|.:|..|:......:::|      |.|        |.|                 ..|..|..
  Fly    43 PPPAAPPRPSPPPTVKLNKC------CHS--------GEY-----------------LNDGTCIA 76

Human   262 MTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQ 326
            .:.:.|.|.  |:.....|||:          |..|                :|..|:.||..:.
  Fly    77 GSEALWLPM--VYLVQQQRFFE----------PHGA----------------SPRFLKFLPNTRP 113

Human   327 HCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGT----ELSLEVQKQ---VDRSVT---LRQNQ 381
            .|    ..|...::.|....|:      ..:|.||    |.:|.||..   ||..|.   |..:|
  Fly   114 TC----RKDQTTEIFRSRGANV------MLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQ 168

Human   382 AVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLV-LEPEKQML----------------- 428
            .:..|:        ||.               .|..||| .||.|..|
  Fly   169 PINALE--------DPD---------------YAANPLVQQEPPKASLRLSKCCGKWGSYNTQLQ 210

Human   429 ---LHETHQ----GLL---------------------QDGSPILLSDVISAFLSNNDTQNLSSPV 465
               |...||    |||                     |.|...:..|...|.|..| |..|..|
  Fly   211 NCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRN-TAMLQLP- 273

Human   466 TFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYD-- 528
                 |:::...|..|    ||.|.               .....|..|.||.|.|.....:|
  Fly   274 -----HKNLSAGQYCL----EHTQR---------------EGEVKIIACQHLFSSAAGAGIHDGS 314

Human   529 ----VQE------EDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAH 583
                :::      :..|||    .|:.||::.|....:...|..|:.:   :||.:..:| ::..
  Fly   315 IGGTIEQANGQNLQKAVLT----GGILVSIVFLSATLVAGFLLPAVHH---ALHWRCQIC-YVTC 371

Human   584 LLF---LVAIDQTGHKV-----LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVV----NY 636
            |||   |:||::....:     .|..:|.|:.:.:||...|:......::.|.|:....    |.
  Fly   372 LLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQ 436

Human   637 SSINRFMKKLMFPVGYGVPAVTVAISAA---------SRP---HLYGTPSRCWLQPEKGFIWG-F 688
            .::.|::..|   ..:|.|.:...::|.         .||   .||     ||.......|:. |
  Fly   437 EALRRYLYSL---YAWGGPLLITFVAACVDQLPETTLLRPGFGQLY-----CWFDNRNLSIFAYF 493

Human   689 LGPVCAIFSVNLVLFLVT-------LWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWC 746
            .||:..:...|:.||:.|       ||...:..||  ||.|.|...      ....:.::|.||.
  Fly   494 YGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSS--SEKSALGRV------CLKLVVVMGVTWI 550

Human   747 LGILQ---VGPAARVMAYLFT-IINSLQGVFIFLV--------------YC-LLSQQVRE----- 787
            ..||.   .||..   .:.|| :||:|||||||:|              :| .|...:..
  Fly   551 ADILSWLVGGPHG---VWFFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGV 612

Human   788 QYGKWSKGIRKLK--TESEMHTLSSSAKADTS---KPSTEAYKDGASEK 831
            |:...|:|:..:.  ||...:|.:::...:|:   .||..| :|...||
  Fly   613 QHSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATHMPSNPA-EDEVPEK 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRE2	XP_011526250.1	EGF_CA	67..117	CDD:284955
		EGF_CA	119..154	CDD:238011
		EGF_CA	163..210	CDD:284955	4/12 (33%)
		EGF_CA	212..246	CDD:284955	5/33 (15%)
		GPS	479..529	CDD:197639	11/55 (20%)
		7tm_4	533..774	CDD:304433	69/276 (25%)
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	69/276 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810