DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRE2 and lat-2

DIOPT Version :9

Sequence 1:	XP_011526250.1	Gene:	ADGRE2 / 30817	HGNCID:	3337	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_001040724.1	Gene:	lat-2 / 173771	WormBaseID:	WBGene00002252	Length:	1338	Species:	Caenorhabditis elegans

Alignment Length:	1049	Identity:	247/1049 - (23%)
Similarity:	395/1049 - (37%)	Gaps:	318/1049 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    45 CRCNPGFSSFSEIITTPMETCD---DINECATLSKVSCG----KFSDCWNTEGSYDCVCSPGYEP 102
            |.|..|:..         :||:   ..|:.|:..: :||    :|| |.|.:.......|.|.:.
Worm   207 CSCPNGYGG---------QTCETQSTTNQQASTQR-TCGSNDFQFS-CPNDQTITVDFASFGAQE 260

Human   103 VSGAKTFKNESENTCQDVDECQQNPRLCKSYGTC-----VNTLGSYTCQCLPGFKLKPEDPKLCT 162
            .|.........|.||.:|:..|.....|:...:|     .:|..:..|..       |::..|.|
Worm   261 SSMCNQASQSREQTCSNVNSLQTVINACQGLQSCEIRNLTSTFSNTPCPV-------PQEQYLET 318

Human   163 DVNECTSGQNPCHSSTHCLNNVGSYQCRC-----------------------RPGWQPIPGSPNG 204
            .: .|.:.|.|     .||:.:..:..||                       :.|...|...|:.
Worm   319 RM-RCETAQQP-----SCLSGLIQFDSRCYSMTIETNEKKQRTMEDAQTYCSQSGGSIITSPPDA 377

Human   205 -----------------------PNNTVCEDVDECSSGQHQCDSS------TVCFNTV--GSYSC 238
                                   |||.....|...|:...||.||      .:| :||  .:.|.
Worm   378 LLQQIVQKVNAETKKTVNFWIGTPNNCQLLMVTGSSTSYSQCPSSPSSTANVIC-STVPQSTASV 441

Human   239 RCRPGW------------------------------KPRH-------GI---------------- 250
            ..||..                              |||:       ||
Worm   442 SARPTQSAPVDPVSQTMARREVYTGVQPPSVPDSINKPRYCKKEKKDGITYEQTRACMLHEQPCP 506

Human   251 -PNNQKDTV---CEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDEL 311
             |.|.:.||   |...| :.|..|.  .:....|:..:::...:|.:|      ::.|...::..
Worm   507 DPQNVEGTVTRYCNCQT-AKWETPD--TTNCTHRWVAEMETAIKDNQP------VEDISSTVNRQ 562

Human   312 LEAP-------GDLETLPRLQQH--CVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAG------- 360
            |::.       ||:....||...  .:|.:....|.|  |.|.:|.:.   ||:...|
Worm   563 LKSTIERTLFGGDITGTVRLSNDMLSLARNQFSVLND--RNLRENKAR---NFTENLGGSGDQLL 622

Human   361 --------TELSLEVQKQ--------VDRSVTL------RQNQAVMQLDWNQAQKSGDPGPSVVG 403
                    .:||..::.|        :::||.|      .|...:..::|....:..:|.....|
Worm   623 SPVAATVWDQLSSTIRIQHASKLMSVLEQSVLLLGDYMTDQKLNLQYINWAMEVERSEPEVQTFG 687

Human   404 LVSIP------GMGKLLAEAPLVLEPE-------KQMLLHET----HQGLL-------------- 437
            ..:.|      ||.:::|.||...:||       ..:.|..|    ...||
Worm   688 AAASPNVQDDMGMMRVMAAAPPAPQPETNTTIMFPSLKLSPTITLPSASLLSSLASPTPVAGGGP 752

Human   438 ------QDGSPI-----------------------------------LLSDVISAFLSNNDTQNL 461
                  ||.:|:                                   :.|.||.|.: .|.||::
Worm   753 SILSSFQDDTPVGMASTPNLNRNPVKLGYYAFAGFGQLLNNNNDHTLINSQVIGASI-QNATQSV 816

Human   462 S----SPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAV 522
            :    .||||||.|.:........||:|:..::   .|:|.||:.|.|...|:.|.||||:|||:
Worm   817 TLPVDHPVTFTFQHLTTKGVSNPRCVYWDLMES---KWSTLGCTLIATSSNSSQCSCTHLTSFAI 878

Human   523 LMAHYDVQEE--------DPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCL 579
            ||   |:..:        ...|.|::.:|.::|::||.|:...|...:.:||...|:|..|.|||
Worm   879 LM---DISGQVGRLSGGLASALDVVSTIGCAISIVCLALSVCVFTFFRNLQNVRNSIHRNLCLCL 940

Human   580 FLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMK 644
            .:|.|:|::.:|:||::..|.::|..|||.:|::..|||||...|:     :.::.....||...
Worm   941 LIAELVFVIGMDRTGNRTGCGVVAILLHYFFLSSFCWMLLEGYQLY-----MMLIQVFEPNRTRI 1000

Human   645 KLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVLFLVTLWI 709
            .|.:...||.|||.|||||..:...|||.|.||:......||.|:.|:..|.:.|::..|:.|.:
Worm  1001 FLYYLFCYGTPAVVVAISAGIKWEDYGTDSYCWIDTSTPTIWAFVAPIIVIIAANIIFLLIALKV 1065

Human   710 LKNRLSSLNSEVSTLRNTRMLAFKATAQLF-ILGCTWCLGILQV--GPAARVMAYLFTIINSLQG 771
                :.|:.|...|.....:...|.:|.|. :||.||..|.|..  |......|::|||:|..||
Worm  1066 ----VLSVQSRDRTKWGRIIGWLKGSATLLCLLGITWIFGFLTAVKGGTGTAFAWIFTILNCTQG 1126

Human   772 VFIFLVYCLLSQQVREQYGKWSK-GIRKL-KTESEMHT----LSSSAKA-------DTSKPSTEA 823
            :|||:::.:|:::||....:|.: ||..| :|.|..:.    |||..:.       ..|.|||.:
Worm  1127 IFIFVLHVVLNEKVRASIVRWLRTGICCLPETSSAAYNSRSFLSSRQRILNMIKVNGHSYPSTAS 1191

Human   824 YKDGASEKE 832
            ..|  .||:
Worm  1192 TDD--KEKQ 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRE2	XP_011526250.1	EGF_CA	67..117	CDD:284955	12/53 (23%)
		EGF_CA	119..154	CDD:238011	6/39 (15%)
		EGF_CA	163..210	CDD:284955	13/92 (14%)
		EGF_CA	212..246	CDD:284955	12/71 (17%)
		GPS	479..529	CDD:197639	20/49 (41%)
		7tm_4	533..774	CDD:304433	81/243 (33%)
lat-2	NP_001040724.1	CLECT	52..193	CDD:214480
		Gal_Lectin	242..322	CDD:280328	18/88 (20%)
		CLECT	330..>399	CDD:295302	7/68 (10%)
		HormR	479..542	CDD:214468	13/65 (20%)
		GAIN	556..>660	CDD:293098	20/108 (19%)
		GPS	837..884	CDD:197639	21/52 (40%)
		7tm_4	894..1129	CDD:304433	81/243 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010