Protein Alignment VSX1 and Ptx1

DIOPT Version :10

• Sequence 1: NP_055403.2
• Gene: VSX1 / 30813
• HGNCID: 12723
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 108/459 - (23%)
• Similarity: 161/459 - (35%)
• Gaps: 154/459 - (33%)

Human    12 TSSRALVPGGSPRGSRPRGFAITDLL-GLEA-----------ELPAPAGPGQGSGCEGPA----- 59
            :|:.||.|||...|.   |..::..| ||||           :| ..||...|:|..|.|
  Fly    23 SSATALGPGGLTNGG---GGVVSGALNGLEAMSAESTGLCLQDL-VSAGTANGAGSAGSAESATT 83

Human    60 VAPCPGPGLDGSSLARGA--------------------------------LPL----------GL 82
            .:.....|..|||...|.                                :|:          |.
  Fly    84 TSTALSSGSTGSSTVNGGGSSTSGTEHLHSHHSLHDSSSSVSISPAISSLMPISSLSHLHHSAGQ 148

Human    83 GLLCGFGTQPPAAARAPCLLLADVPFLPPRGPEPAAPLAPSRPPPALGRQKRSDS---------- 137
            .|:.|:...|....            :||..|: ..||...|.....|..:.|.|
  Fly   149 DLVGGYSQHPHHTV------------VPPHTPK-HEPLEKLRIWAETGDFRDSHSSMTAVANSLD 200

Human   138 ---------VSTSDEDSQSEDRNDLKAS--------------------PTLGK--------RKKR 165
                     .|||...::|.||.|...|                    .|.|:        :::|
  Fly   201 STHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQR 265

Human   166 RHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSS 230
            |.||.||:.||:|||..||...|||:..||.:|:.|.|.|.|::|||:||||||||||:....::
  Fly   266 RQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAA 330

Human   231 VMAEYGLYGAMVRHCIPLPDSVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGLWGSD 295
            |.|.....|...:...|..|..|.|:......:..|       ..:|....|...:.|..:...:
  Fly   331 VAAADFKSGFGTQFMQPFADDSLYSSYPYNNWTKVP-------SPLGTKPFPWPVNPLGSMVAGN 388

Human   296 HFKEGSSQSESGSQRGSDKVSPENGLEDVAIDLSSSARQETKKVHPGAGAQGGSNSTALEGPQPG 360
            |.:...:...:|:             ..||:.:::::      :.||:.....||::.:     |
  Fly   389 HHQNSVNCFNTGA-------------SGVAVSMNNAS------MLPGSMGSSLSNTSNV-----G 429

Human   361 KVGA 364
            .|||
  Fly   430 AVGA 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		8/24 (33%)
		Octapeptide motif	31..38		1/7 (14%)
		PRK14959	<47..>149	CDD:184923	29/167 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..167		18/100 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		0/12 (0%)
		Homeodomain	165..221	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..365		12/75 (16%)
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	32/55 (58%)