DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adamts8 and AdamTS-B

DIOPT Version :9

Sequence 1:	NP_038934.2	Gene:	Adamts8 / 30806	MGIID:	1353468	Length:	905	Species:	Mus musculus
Sequence 2:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	300/933 - (32%)
Similarity:	447/933 - (47%)	Gaps:	146/933 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    52 ASELAFHLSAFGQGFVLRLAPDASFLAPEFKIERLGGSSAAAGGEPGLR----------GCFFSG 106
            |::|...|....:...|.|...:.||||...:||         ....||          .|.|.|
  Fly    90 AADLHLLLPLANETLHLELMAHSYFLAPNLVVER---------HRRDLRTRSPLTTRHLNCHFHG 145

Mouse   107 TVNGERESLAAMSLCRGLSGSFLLAGEEFTIQPQGAGD---------------SLDQPHRLQRWG 156
            .|.|:..:..|:|.|.||.|....||.|:.|:|....:               |:...|.|::..
  Fly   146 KVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRN 210

Mouse   157 PGQRREDPGLAAAEVF---------PLPQGLEWE----VEMGNGQGQERSDNEEDRKQDKEGLLK 208
            ..:|....| :.|||.         .:...|||:    |::..|:...|..:.......|.....
  Fly   211 KRKRGGKSG-SGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRH 274

Mouse   209 ETEDSRKVP-------------PPFGSKTRSKRFVSEARFVETLLVADASMAAFYGTDLQNHILT 260
            ..:...:||             |......|.:|.:|..|.||||:||||:|:||: .||..::||
  Fly   275 HQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH-RDLNGYLLT 338

Mouse   261 VMSMAARIYKHPSIRNSVNLVVVKVLIVEEEGWGPE--VSDNGGLTLRNFCSWQRRFNKPSDRHP 323
            :|:|.:.:||.|||.||:.:|||:::.::||....:  ::.|....|..|||||.:.||.|::.|
  Fly   339 IMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDP 403

Mouse   324 EHYDTAILFTRQNFCGKGEQCDTLGMADVGTICDPDKSCSVIKDEGLQAAYTLAHELGHVLSMPH 388
            .|:|.|||.||:|.|  ...|.|||:|:||.:|.|.:||||.:|.|:..::|:.|||||...|.|
  Fly   404 HHHDVAILITRKNIC--ANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFH 466

Mouse   389 DDSK-PCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPLP- 451
            |.:| .|....||:  .|:|.|.|......:.||.||..|:|..||.|.|:||.|.||   ||.
  Fly   467 DTAKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPT---PLDE 526

Mouse   452 ---TG-LPGHSTLYELDQQCKQIFG----PDFRHCPNTSVEDICVQLWCRHRDSDEPICHTKNGS 508
               || |||  ..|....||:..|.    .:...|  ::..:.|..|||  :.:.|.:.|.:.
  Fly   527 YNYTGELPG--MRYNARGQCRLQFNLTTDSEVGAC--SAPHEFCSTLWC--KVNGECVTHMRP-- 583

Mouse   509 LLWADGTPCGPGHLCLDGSCVLKEDVENPKAVVDGDWGPWRPWGQCSRTCGGGIQFSNRECDNPM 573
              .|.||.||....|.:|.||.:|::    |.|:|.||.|..|.:|||:||||:....||||||:
  Fly   584 --TAPGTLCGRNKWCQNGKCVRREEL----AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPV 642

Mouse   574 PQNGGRFCLGERVKYQSCNTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDR 638
            |.|||.||:|||.:|:.|....||....|||.|||.:   :::....|...:|:|.:...:|
  Fly   643 PANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCAR---FDNVSYQGATYKWLPFFDKNNP--- 701

Mouse   639 CKLFCRARGRSEFKVFEAKVIDGTLCGPDTLSICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGT 703
            |||||.....:....:.|.|:|||.|...|.::|:.|.|.|.|||.:|:|..:.|:||||||.|.
  Fly   702 CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGD 766

Mouse   704 ACRKISGSFT-PFSY---GYNDIVTIPAGATNIDVKQRSHPGVRNDGSYLALKTANG--QYLLNG 762
            .|:.:..::| ||:.   .|.:||||||.|.:|.:::     :.|...:||:.|.:|  ::.|||
  Fly   767 QCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDGGDRFYLNG 826

Mouse   763 NLAISAIEQDILVKGTILKYSGSMATLERL--QSFQALPEPL--TVQLLT-VSGEVFPPKVRYTF 822
            :..||...:        .:.:|:.:..:|:  |....:|:|:  ::.|.. |.|......:.|.|
  Fly   827 DSLISMPGE--------FEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEF 883

Mouse   823 FVPNDMDFSVQNSKERATTNIIQSLPSAEWVLGDWSECPSTCRGSWQRRTVECRDPSGQASDTCD 887
            .:|              ..|:... ...:|.|.:|:.|.::|.|..|.|...|::......||..
  Fly   884 TLP--------------ALNVTAG-RQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLP 933

Mouse   888 EALKPEDAKP------CGSQPCP 904
            .....::.:|      ||.||||
  Fly   934 CWTHAKNKRPARQSRGCGDQPCP 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adamts8	NP_038934.2	Pep_M12B_propep	52..152	CDD:279848	31/124 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..163		5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..225		6/51 (12%)
		Reprolysin	234..444	CDD:279729	95/212 (45%)
		ZnMc_ADAMTS_like	234..441	CDD:239801	93/209 (44%)
		ADAM_CR	463..529	CDD:301627	17/69 (25%)
		TSP1	545..597	CDD:214559	28/51 (55%)
		Spacer	706..847		34/151 (23%)
		ADAM_spacer1	706..825	CDD:283607	32/129 (25%)
		TSP1	852..904	CDD:214559	16/57 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..905		9/34 (26%)
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	29/112 (26%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	92/208 (44%)
		Reprolysin	315..521	CDD:279729	94/210 (45%)
		ADAM_CR	<558..602	CDD:301627	14/51 (27%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	32/125 (26%)
		TSP1	901..956	CDD:214559	14/54 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720