DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a4 and CG7458

DIOPT Version :9

Sequence 1:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus
Sequence 2:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	160/564 - (28%)
Similarity:	272/564 - (48%)	Gaps:	52/564 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSS----SWRNH 65
            |.::..:|::|.:|.:.:.||...::.|.|..:|.||.|.|..|||.||...:.||    .|...
  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103

Mouse    66 SIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQ---LEQESCLDGWEY-DKDIFLS 126
            :||.:    ......|.|| .|.|::..:...:|.....|::   :..|:|...::: |::   .
  Fly   104 TIPKK----NSAWDDCHRY-AANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE---K 160

Mouse   127 TIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFST 191
            ||.||:.:.|||:||..:..::..||...|..:.|..:||:||:.:|....:|......::..|:
  Fly   161 TISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSS 225

Mouse   192 NWEMFTVL-FAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRD 255
            |:.||.|. |..:.:|. :.:..||:|..|::....|:..:|: :..|:|:|...|...|..::.
  Fly   226 NYSMFLVFEFLDMAVGS-TLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGFLASQVQH 288

Mouse   256 WRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQE 320
            ||.||..|..|.:..:...|.:|||.|||:||....:|..::::||::|.        .||..::
  Fly   289 WRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQ--------RPLPEEQ 345

Mouse   321 LNSL-------------KQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDV 372
            ||.|             .|..::...:|.:..||.    ..:.|...::....||||..||.|:.
  Fly   346 LNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIAN----CCLCWFTHTLIALGLSLNSVNLGGNK 406

Mouse   373 YLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKF 437
            |.|..|:|.|::|......:::..:.||:.:...:......:.....||.|....|:.|.::||.
  Fly   407 YTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKL 471

Mouse   438 GITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLI 502
            .||.:|.:||.||:|::||.|||..:.:.||..|:||::||....|..|....|.||..:..::.
  Fly   472 AITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALIS 536

Mouse   503 GIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSVDREESP 546
            |.:||.|||:....||..:|:   .|.....|:.:     |.||
  Fly   537 GFLTLAFPETADKVLPTTIEE---ARDLNQAKRRS-----ERSP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	152/528 (29%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	116/400 (29%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	153/529 (29%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	116/396 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.980