DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a4 and SLC22A

DIOPT Version :9

Sequence 1:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	160/570 - (28%)
Similarity:	281/570 - (49%)	Gaps:	55/570 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDT----VNLSSSWRNH 65
            |.::..||::|.||.:||.|:...::.:....::.||.|.|..|||.|.:.    .|......|.
  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNW 92

Mouse    66 SIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLE-----QESCLDGWEYDKDIFL 125
            |||   |:|:.: .||.||..:.:..::       ..||:...:     :|:|    .:::.:|.
  Fly    93 SIP---KNGKDL-DSCNRYTNSELPQWN-------HSVDICSADHFTKNKEAC----AHNEFVFR 142

Mouse   126 S---TIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRK------KVLFATMAVQT 181
            .   ||..::.:.|:|:||..:..::..:|...|..:.|.::||:||.      .:|.|.:.|
  Fly   143 DDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV-- 205

Mouse   182 GFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVL 246
                ::.||.::..|.|...:..|...:.|...|::|.|::....|::..:: :..|:|:|.::|
  Fly   206 ----IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVFYAVGEVLL 265

Mouse   247 PLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAG 311
            .:.|....|||:||.....|.|..:..:|.:|||.|||:||.:...|:.|:::||.:|....|..
  Fly   266 AMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPES 330

Mouse   312 IFDPLELQELNSLKQ---QKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVY 373
            :.|.|.|...:.|:|   .:..|.:.|  :|.........:.|::..:.|:.|||||..|.||.|
  Fly   331 VLDKLVLANRDKLQQSSESRFPIREAF--KNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKY 393

Mouse   374 LNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKFG 438
            .|.....|:|:|.:|...|::....|||.:.|::...|...:.......|...:.:.|.::||..
  Fly   394 NNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLT 458

Mouse   439 ITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIG 503
            ||::|.:||.|.:|:|||.:||..:...||..|.||::||....|..|....|.:|.....::.|
  Fly   459 ITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSG 523

Mouse   504 IITLFFPESFGVTLPENLEQMQKVRGFRCG-KKSTVSVDREESPKVLITA 552
            ::||||||:..|.||..:::...:     | ||.:.|.|.:    :::||
  Fly   524 LLTLFFPETTNVVLPTTVQEADAI-----GVKKQSKSKDLD----LVVTA 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	150/527 (28%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	115/398 (29%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	151/528 (29%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	114/392 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.980